RESUMO
Prolonged survival of pancreatic xenografts in the muscles of diabetic rabbits was achieved. The mean graft survival time (assessed by euglycemic status) in nonimmunosuppressed (Group A) was 10 days and in immunosuppressed (Group B) was 36 days (P < 0.05). Adequate immunosuppression helps pancreatic xenograft to normalize blood glucose level (BGL) by prolonging survival time. Our study demonstrates that xenotransplantation of islet cells in their natural environment (pancreatic tissue in four of thin slices) survive and function adequately in immunosuppressed recipients. This discordant Xenotransplantation model may be useful for future xenotransplantation studies.
Assuntos
Animais , Glicemia/análise , Diabetes Mellitus Experimental/sangue , Cabras , Sobrevivência de Enxerto/fisiologia , Terapia de Imunossupressão , Transplante de Pâncreas/patologia , Coelhos , Fatores de Tempo , Transplante HeterólogoRESUMO
Experiments were conducted on 24 mongrel dogs to study the effect of phenylbutazone on acute experimental pancreatitis. Necrotico-hemorrhagic pancreatitis was produced by local infiltration of autologous bile. The severity of pancreatitis was assessed by biochemical estimation and histopathological examination. Pretreatment with phenylbutazone reduced the severity of pancreatitis, both biochemically and histologically (total score 6.0 +/- 1.52 in the test group vs 8.33 +/- 1.80 in the control group; p less than 0.01).