RESUMO
Objective: Curcumin protects the liver against injury and fibrosis through suppressing hepatic inflammation, attenuating hepatic oxidative stress [OS], and inhibiting hepatic stellate cells [HSCs] activation. Non-alcoholic fatty liver disease [NAFLD] and polycystic ovary syndrome [PCOS] are considered as common metabolic disorders. Low-grade chronic inflammation with different markers, such as elevated C-reactive protein [CRP] and interleukin-6 [IL-6] levels, play a crucial role in PCOS. This study aimed to evaluate the therapeutic effects of curcumin on IL-6 and CRP levels as well as insulin resistance [IR] index on liver function in PCOS rats
Materials and Methods: In this experimental study, 90 adult Wistar rats were divided into control [n=18], sham [n=18], PCOS [n=18] and curcumin-treated PCOS groups [n=36]. PCOS group was injected subcutaneously with 2 mg estradio-valerate [E2V]. After 60 days, PCOS group was treated with curcumin [100 and 300 mg/kg body weight [BW]] for 14 days and anesthetized by chloroform. Blood and liver samples were collected for histological and serological analyses. Data were analyzed using In-Stat 3 via one-way analysis of variance [ANOVA]
Results: Histological and serological analyses showed a reduction in number of necrotic cells, IR index, as well as IL-6 and CRP levels in PCOS rats that were treated with various concentrations of curcumin
Conclusion: In this study, curcumin decreased liver inflammation by induction of insulin sensitivity and reduction of hepatic necrosis. Therefore, curcumin may be considered as protective factor against inflammatory state of PCOS
RESUMO
Introduction and Aims: In the event of damage to the skin, the epidermis of which goes to the disintegration of the body, is a wound that is common in diabetics. The purpose of this study was to evaluate the effect of aqueous extract of grape [Vitis Vinifera] on wound healing in diabetic Wistar rat
Materials and Methods: In this study 48 male Wistar rats were divided into 4 groups [control, sham, experimental 1, empirical 2] were tested. The extra pawn injured area of 3 cm to the left of the spine created. Extract-treated group compared to one in three [aqueous extract + eucerin] received. Wound healing was examined microscopically during 21 days
Results: Wound healing in group that became diabetes using streptozocin [the diabetic rats], showed late recovery compared to normal wound healing in normal groups and wound healing in experimental groups treated with aqueous extract of grape was accelerated compared control group
Conclusion: The results showed that the aqueous extract of grape skin accelerate wound healing in normal and diabetic samples
RESUMO
Background: Arresting at a certain stage of development like the two-cell stage could be one of the causes of infertility. The aim of this study is to evaluate the effects of ethanol and strontium on growth and development of mice embryos arrested at the two-cell stage
Materials and Methods: In this experimental study, female mice were coupled with a male following superovulation. Positive vaginal plug mice were sacrificed 48 hours after human chorionic gonadotropin [hCG] injection. Two-cell embryos were transferred to M16 medium and divided to four groups. The first control group was incubated without any exposure to low temperatures. Groups 2, 3 and 4 were exposed to 4[degree]C for 24 hours. The second control group was incubated immediately, while the third and fourth groups were exposed to 10 mM strontium for five minutes and 0.1% ethanol for a further five minutes. Growth rate and developmental parameters of embryos were analyzed by one-way ANOVA. The significant difference between the groups was determined by Post Hoc
Results: The data shows that developmental rate is decreased significantly by 4[degree]C exposure. The mean percentage of degenerated embryo was significantly different between groups but the mean cleavage rate was not significantly different. The mean percent of morula, blastocyst and hatched blastocyst formation were significantly different between groups during a 120 hours study post hCG injection
Conclusion: The effect of strontium and ethanol on arrested two-cell embryos had no significant effect on the mean percentage of morula, but ethanol treatment significantly increased the percentage of blastocyst and hatched blastocyst formation compared to strontium