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Asian Journal of Andrology ; (6): 315-324, 2003.
Artigo em Inglês | WPRIM | ID: wpr-300879

RESUMO

During spermiogenesis, the protamine proteins play an integral role in spermatid chromatin compaction. Recent research has focused on many facets of protamine biology, including protamine gene and protein structure/function relationships, mechanisms of protamine expression regulation and involvement of the protamines in male fertility. In this paper, we review our current understanding of the structure and function of the protamine-1 (P1) and protamine-2 (P2) proteins and genes, the expression and regulation of these genes and the relationship between the protamines and male fertility. In addition, we offer a brief outlook on future investigation into protamine proteins.


Assuntos
Humanos , Masculino , Sequência de Aminoácidos , Regulação da Expressão Gênica , Infertilidade Masculina , Dados de Sequência Molecular , Protaminas , Química , Genética , Metabolismo , Espermátides , Fisiologia
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