Association between Interleukin-5 and Body Mass Index among Iraqi asthmatic patients

Asthma is an allergic hypersensitivity disease in which many mediators play a role in its pathogenecity. One of these etiological agents are the mediators such as lnterleukin-5 [IL-5]. The aim of this study is to demonstrate the association between IL-5 and obesity in asthma development. One hundred and four sera samples for asthma cases have been studied in comparison with 41 non-asthmatic bronchitis as patient controls beside 30 apparently healthy controls. Cytokine has been estimated using ELISA method in correlation with Body Mass Index [BMI]. This study revealed a significant correlation between IL-5 concentration and BMI [P<0.05], particularly among females. There is certain correlation between obesity and asthma accompanied by IL-5

Possible role for lnterleukin-5 in asthma

Asthma is an allergic disease characterized by airway obstruction as a result of cellular accumulation due to the liberation of certain mediators. Among those mediators are the cytokines such as IL-5. lnterleukin-5 concentration has been estimated in 94 sera samples of Asthmatic patients in comparison with 41 non-asthmatic bronchitis as patient controls in addition to 30 apparent healthy control group using ELISA method. There is highly significant elevation of IL-5 in the asthmatic cases in comparison with healthy controls [P< 0.001]. We conclude that this cytokine may play the major role in asthmatic attack and it may be a good marker for the disease