RESUMO
HBsAg, HBcAb and HBsAb were examined with radio-immunoassay in 265 patients with glomerular disease, who were admitted to wards or visited to outpatient clinics of department of pediatrics, Seoul National University Hospital, from Jan., 78 to Oct. 80, and in 576 control group, with other than liver disease and without history of transfusion. The incidence in glomerular disease was 10.2%(27 of 265 patients)-nephrotic syndrome 9.2%(12 of 130); acute glomerulonephritis 7.3%(5 of 68), recurrent hematuria 7.7%(2 of 26), H-S nephritis 25%(3 of 12), chronic renal failure 21%(3 of 14), and the others 13.3%(2 of 15), while the incidence of HBs antigenemia in control group was 5.03%(29 of 576 patients)-male 5.5%(21 of 362), female 4.2%(8 of 214). The overall incidence of HBs antigenemia in renal disease was statistically higher than that of control group(p<0.05), though the respective incidences of the above each renal disease group were somewhat higher than that of control group, however they were not statistically significant, The incidence of positive rate of HBsAb and/or HBcAb in control group was 26.7%(56 of 209), and that in renal disease was 23%(18 of 578).
Assuntos
Criança , Feminino , Humanos , Instituições de Assistência Ambulatorial , Glomerulonefrite , Hematúria , Antígenos de Superfície da Hepatite B , Incidência , Falência Renal Crônica , Hepatopatias , Nefrite , Pediatria , SeulRESUMO
Cushing's syndrome is a rare entity in pediatric age, and and mostly caused by adrenocotical tumor. We recently experiecd 2 cases of Cushing's syndrome, one, 13 year and 4 month old girl with bilateral adrenocortical hyperplasia, and one, 2 year and 4 month old girl with huge adrenocortical carcinoma measuring 14x13x8cm, thought to be congenital in origen. The former was successfully treated by bilateral adrenalectomy. The latter showed no evidence of metastasis at operation, but expired 7 months later due to metastatic carcinoma. Literature about Cushing's syndrome were reviewed.
Assuntos
Feminino , Humanos , Lactente , Adrenalectomia , Carcinoma Adrenocortical , Síndrome de Cushing , Hiperplasia , Metástase NeoplásicaRESUMO
Methylprednisolone pulse therapy was performed for 8 patients of childhood nephrotic syndrome who showed resistance to conventional prednisolone therapy of 4 to 8 weeks. The pathological diagnosis of the patients were: 1 case of membranous nephropathy, membrano-proliferative glomerulonephritis, Menbranoproliferative glomerulonephritis with epithelial crescent (70%), sclerosing glomerulonephritis, mesangial proliferative glomerulonephritis, focal and global glomerulonephritis, and 2 cases of focal and segmental glonerulosclerosis. Creatinine clearance was above 50% of the normal in 7 cases, and less than 20% in crescentic glomerulonephritis. 20% in crescentic glomerulonephritis. 30gm/kg/D. of methylprednisolone was administered intravenously over 1~2hours, which was repeated 2 to 9 times on every other day. Thereafter, alternate day prednisolone therapy was continued. The results were as follows: Remission was attained in membranous nephropathy and MPGN, within 9 weeks and 13 weeks respectively. Marked improvement was noted in crescentic glomerulonephritis. Ccr increased from 18.5ml/min/1.73mm(2) to 59.1ml/min/1.73mm(2) 10 days later after pulse? Sclerosing glomerulonephritis showed significant improvement in clinical finding and serum albumin. There was no improvement in mesangial proliferative glomerulonephritis, focal and global glomerulonephritis, and 2 cases of focal and segmental glomerulosclerosis. These findings suggest that methylprednisolone pulse?therapy may benefit the childhood nephrotic syndrome with resistance to conventional prednisolone therapy.