RESUMO
The synthetic potency of E-3-[dimethylamino]-1-[1H-pyrrol-2-yl]prop-2-en-1-one towards some nitrogen nucleophiles was investigated under microwave irradiations as a convenient route for the synthesis of some novel pyridine, pyrimidine, pyrazole, pyrazolo [1,5-a] pyrimidine and Triazolo[1,5-a] pyrimidine derivatives
Assuntos
Pirimidinas/síntese química , Piridinas/síntese química , Pirazóis/síntese química , Micro-Ondas , Compostos Heterocíclicos/síntese químicaRESUMO
Pyrazole derivatives 3a,b were formed upon reacting phenylhydrazine with ketene S, S-acetal or tetracyanoethylene. The pyrazole derivatives 3a, b were in turn used as precursors for the preparation of pyrazolo [3,4-d] pyrimidines which are expected to possess considerable chemical and pharmacological activities. The antimicrobial activity of the prepared compounds was tested
Assuntos
Pirazóis/síntese química , Antibacterianos , Tioureia , Hidrazinas , BioensaioRESUMO
Oxime of ethyl-3-oxobutanate [1] reacts with malononitrile and ethyl cyanoacetate to yield isoxazol derivatives [3a, b]. The products are further modified to new isoxazol and its fused derivatives. Oximes of beta-ketoesters and beta- oxonitriles are versatile magnets which have been used as substrates for the synthesis of heterocyclic compound [1-3] which are of potential biological activities [4-6]. This work was described to extent synthetic routs to new isoxazol derivatives using malononitrile and ethyl cyanoacetate as active methylene reagents in reaction with oxime of ethyl acetoacetate
RESUMO
Ammoniumn- phenyldithiocarbamate reacted with bromomalononitrile and alpha chloroacetylacetone to afford thiazole derivatives 3a, b. Compound 3a reacted with benzylidenemalononitrile, malononitrile, phenylisothiocyanate, benzoylisothiocyanate, trichloroacetonitrile, formamide, carbon disulphide and triethylorthoformate to afford thiazolo [4,5-b] pyridine derivatives 6,9 and thiazolo [4,5-d] pyrimidine derivatives 13, 16, 18, 19, 20 and 21. Most of the synthesized products show high fungicidal and bactericidal activities