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Background@#and Purpose To examine the clinical and safety outcomes after endovascular treatment (EVT) for acute basilar artery occlusion (BAO) with different anesthetic modalities. @*Methods@#This was a retrospective analysis using data from the Endovascular Treatment for Acute Basilar Artery Occlusion (ATTENTION) registry. Patients were divided into two groups defined by anesthetic modality performed during EVT: general anesthesia (GA) or non-general anesthesia (non-GA). The association between anesthetic management and clinical outcomes was evaluated in a propensity score matched (PSM) cohort and an inverse probability of treatment weighting (IPTW) cohort to adjust for imbalances between the two groups. @*Results@#Our analytic sample included 1,672 patients from 48 centers. The anesthetic modality was GA in 769 (46.0%) and non-GA in 903 (54.0%) patients. In our primary analysis with the PSM-based cohort, non-GA was comparable to GA concerning the primary outcome (adjusted common odds ratio [acOR], 1.01; 95% confidence interval [CI], 0.82 to 1.25; P=0.91). Mortality at 90 days was 38.4% in the GA group and 35.8% in the non-GA group (adjusted risk ratio, 0.95; 95% CI, 0.83 to 1.08; P=0.44). In our secondary analysis with the IPTW-based cohort, the anesthetic modality was significantly associated with the distribution of modified Rankin Scale at 90 days (acOR: 1.45 [95% CI: 1.20 to 1.75]). @*Conclusion@#In this nationally-representative observational study, acute ischemic stroke patients due to BAO undergoing EVT without GA had similar clinical and safety outcomes compared with patients treated with GA. These findings provide the basis for large-scale randomized controlled trials to test whether anesthetic management provides meaningful clinical effects for patients undergoing EVT.
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Objective: To establish an HPLC method for the determination of baicalin and phillyrin in Qinqiao oral solutions. Methods:The column was Inertsil ODS-SP(250 mm × 4. 6 mm, 5 μm). The mobile phase consisted of acetonitrile-phosphate buffer (11. 5 g ammonium dihydrogen phosphate was dissolved in water, and then 1ml phosphoric acid was added, finally the solution was di-luted to 1 000 ml by water)(75∶25). The flow rate was 1. 0 ml·min-1, the detection wavelength was at 278 nm and the column tem-perature was 25℃. Results:The calibration curve was linear within the range of 0. 203-4. 064 μg(r=0. 999 8) for baicalin and 0. 182-3. 648μg(r=0. 999 7) for phillyrin. The average recovery was 100. 9% with RSD of 1. 7% (n=5) and 100. 5% with RSD of 1. 4% (n=5), respectively. Conclusion:The method is simple, practicable, accurate and rapid, which can be applied in the determi-nation of baicalin and phillyrin in Qinqiao oral solutions.