Demand for health care service and associated factors in rural children under 7 years old of Ningxia / 中国学校卫生

Objective@#This paper aims to understand demands for health care service demand and associated factors among children under 7 years old in rural areas of Ningxia,and to provide the statistical support for changing the hygiene resources mode and public hygiene admistration.@*Methods@#Data of 12 887 children selected from Rural Residents Family Health Survey in five counties of Ningxia (Haiyuan, Yanchi, Tongxin, Pengyang and Xiji) in 2009, 2011, 2012 and 2015 were collected. Demand for health care service and associated factors of children under 7 years old were analyzed through univariate analysis and multivariate Logistic regression in SPSS 23.0.@*Results@#Demand for health care services among children under 7 years old in rural areas of Ningxia was relatively high. Univariate analysis showed that children with different distances from medical institutions, family size and family income status showed significantly different rates of two-week sickness visits(χ2=6.56,6.81,29.52,P<0.05). Multivariate Logistic regression analysis showed that children with older age, large family population, low level of family income and long-term parental employment outside the home may be the risk factors for children under 7 years of age to see a doctor(P<0.05).@*Conclusion@#Physical accessibility,family income and parental employment outside the home for a long period are the main factors affecting demand for health care services for children in this area,the government should continue to improve the conditions of primary health facilities, adjust macro health policies, and promote the good and rapid development of child health in this area.

Synthesis and structure-activity relationship of cycloberberine as anti-cancer agent / 药学学报

A series of cycloberberine derivatives were designed, synthesized and evaluated for their anti-cancer activities in vitro. Among these analogs, compounds 6c, 6e and 6g showed strong inhibition on human HepG2 cells. They afforded a potent effect against DOX-resistant MCF-7 breast cells as well. The primary mechanism showed that cell cycle was blocked at G2/M phase of HepG2 cells treated with 6g using flow cytometry assay. It significantly inhibited the activity of DNA Top I at the concentration of 0.1 mg mL-1. Our results provided a basis for the development of this kind of compounds as novel anti-cancer agents.

Synthesis and structure-activity relationship of N-(2-arylethyl) isoquinoline derivatives as anti-cancer agents / 药学学报

A series of novel N-(2-arylethyl) isoquinoline derivatives were designed, synthesized and evaluated for their anti-cancer activities. Among these analogs, compound 9a exhibited the potential anti-cancer activities on HepG2 and HCT116 cells with IC50 values of 2.52 and 1.99 microg x mL(-1), respectively. Cell cycle was blocked at S phase of HepG2 cells treated with 9a by flow cytometry detection. Our results provided a basis for the development of a new series of anti-cancer candidates.