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Objective To observe clinical efficacy and safety on the treatment of moderate-severe cancer pain by Fluvoxamine combined with Oxycodone. Methods 120 cancer patients with moderate pain and 120 cases with severe pain were selected, randomly divided into experimental group and control group. The control group were given oxycodone alone , and experimental group given fluvoxamine combined with oxycodone , till the pain relieved, then the degree of pain relief, oxycodone dosage, life quality and side effects were evaluated. Results The degree of pain relief in experimental group were much better than control group (P < 0.05). Oxycodone consumption were lower in experimental group than control group , and the difference was no significant difference in controlling moderate pain (P = 0.065), while statistically significant in controlling severe pain (P = 0.035). The general status, daily activity, mood, and sleep affected by cancer pain were released after treatment, especially in experimental group (P < 0.05). The most common side effects were approximative, and the incidence of constipation, nausea/vomiting, lethargy were lower in experimental group than control group (P =0.026). Conclusion Fluvoxamine combined with Oxycodone can effectively control moderate-severe cancer pain, and reduce the oxycodone dosage and some side effects, and therefore, improve the quality of life.
RESUMO
Objective:To explore the changes of cell cycles in white lesion of the vulvar after focused ultrasound treatment.Methods:30 patients were treated with focused ultrasound therapy from 2005 to 2007.Cyclin D1 and Cyclin Dependent Kinase(CDK4)were examined by strepavidin peroxidase immunohistochemistry.Statistical analysis was performed using SPSS.Results:The positive cell staining intensity of Cyclin D1 and CDK4 were significantly higher in white lesion of the vulvar than those of normal vulvar skin(P