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National Journal of Andrology ; (12): 1031-1034, 2015.
Artigo em Chinês | WPRIM | ID: wpr-304776

RESUMO

Follicle-stimulating hormone (FSH) is synthesized and secreted by the anterior pituitary, which binds to its receptors expressed on the membrane of Sertoli cells in the testis to bring about spermatogenesis. With the development of DNA sequencing technology, FSH SNPs rs10835638 and FSHR SNPs rs6165, rs6166, and rs1394205 were detected, which might directly affect the expression of FSH and activity of FSHR, resulting in male spermatogenic dysfunction. This review focuses on the relationship of FSH and FSHR gene polymorphisms with male infertility.


Assuntos
Humanos , Masculino , Hormônio Foliculoestimulante , Genética , Infertilidade Masculina , Genética , Polimorfismo de Nucleotídeo Único , Receptores do FSH , Genética , Células de Sertoli , Espermatogênese , Testículo
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