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National Journal of Andrology ; (12): 607-610, 2003.
Artigo em Chinês | WPRIM | ID: wpr-357125

RESUMO

Lactate dehydrogenase-C4 isozyme has been widely studied as the sperm-specific antigen in the research of the contraceptive vaccine. Developmental and testis-specific expression of the LDH-C gene requires mechanisms for activation in germ cells and repression in somatic cells. LDH-C promoter, several transcription factors and methylation of CpG dinucleotides have been proved of governing action on LDH-C gene transcription. The strategy is to induce antibodies in the female reproductive tract against LDH-C antigens at a sufficient level to block fertilization. Chemically modified LDH-C4 offers a potential application in the induction of infertility of homologous species in marked contrast to native LDH-C4. In addition, advances are being made in researches on the male contraceptive vaccine and synthetic peptide immunocontraceptive.


Assuntos
Animais , Humanos , Masculino , Camundongos , Coelhos , Isoenzimas , Genética , Alergia e Imunologia , L-Lactato Desidrogenase , Genética , Alergia e Imunologia , Papio , Espermatozoides , Transcrição Gênica , Vacinas Anticoncepcionais , Alergia e Imunologia
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