IN VIVO ~1H NMR SPECTROSCOPY IN RAT C6 GLIOMA / 解放军医学杂志

By using the high magnetic field spectrometer to assess the practical value of 1 H NMR spectroscopy in vivo through observation of changes in metabolism of C6 glioma, fourty Wister rats were divided into two groups: ten as controls, and in thirty rats C6 glioma cells were implanted spheroids in right caudate nucleus. MR images were carried out at intervals. The 1 H NMR spectroscopy were performed by using point resolved spectroscopy (PRESS) technique. The NAA Cho, Cr+PCr, Glu+Gln, Lip, Lac were observed in normal rats. The NAA intensity was seen to be decreased or disappeared in C6 glioma, and NAA/Cho ratio and NAA/Cr ratio decreased obviously( P