RESUMO
After multidisciplinary treatment including radiotherapy, the median survival of patients with glioblastoma multiforme (GBM) remains approximately 1 year. The heterogeneity of the genome and proteome of glioblastoma stem cells (GSC) is the fundamental factor affecting the prognosis. Proteomics-based sensitization of key radioresistance proteins is expected to improve the prognosis of GBM patients. In this article, literature review was conducted from PubMed and other databases in the previous 10 years to systematically discuss the research progress on various commonly used protein quantitative techniques, tools for data processing analysis and the application in radioresistance and radiosensitization of GSCs.
RESUMO
After multidisciplinary treatment including radiotherapy,the median survival of patients with glioblastoma multiforme (GBM) remains approximately 1 year.The heterogeneity of the genome and proteome of glioblastoma stem cells (GSC) is the fundamental factor affecting the prognosis.Proteomics-based sensitization of key radioresistance proteins is expected to improve the prognosis of GBM patients.In this article,literature review was conducted from PubMed and other databases in the previous 10 years to systematically discuss the research progress on various commonly used protein quantitative techniques,tools for data processing analysis and the application in radioresistance and radiosensitization of GSCs.