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Objective:To investigate the clinical efficacy and adverse reactions of 192Ir 3-dimensional intraluminal post-loading radiotherapy in treatment of locally middle and advanced cervical cancer. Methods:The clinical data of 100 middle and advanced cervical cancer patients in Shanxi Province Cancer Hospital from February 2018 to January 2021 were retrospectively analyzed, including 50 patients undergoing 192Ir 3-dimensional intraluminal post-loading radiotherapy (the 3D group) and 50 patients undergoing 192Ir 2-dimensional intraluminal post-loading radiotherapy (the 2D group). The therapeutic efficacy and adverse reactions of both groups were compared. Results:The objective response rate of the 3D group was higher than that of the 2D group, and the difference was statistically significant [98% (49/50) vs. 84% (42/50), χ2 = 4.40, P = 0.036]. The overall incidence of acute radioactive cystitis in the 3D group was lower than that in the 2D group, and the difference was statistically significant [60% (30/50) vs. 88% (44/50), χ2 = 10.19, P = 0.003]. The incidence of grade 1 acute radiation cystitis in the 3D group was lower than that in the 2D group, and the difference was statistically significant [26% (13/50) vs. 48% (24/50), χ2 = 5.19, P = 0.038]. The overall incidence of acute radiation enteritis in the 3D group was lower than that in the 2D group, and the difference was statistically significant [68% (34/50) vs. 92% (46/50), χ2 = 9.00, P = 0.005]; the incidence of grade 2 and 3 acute radiation enteritis in the 3D group was lower than that in the 2D group, and the differences were statistically significant [28% (14/50) vs. 50% (25/50); 4% (2/50) vs. 20% (10/50), χ2 = 5.09, P = 0.040; χ2 = 6.06, P = 0.028]. The overall incidence of chronic radiation enteritis in the 3D group was lower than that in the 2D group, and the difference was statistically significant [28% (14/50) vs. 54% (27/50), χ2 = 6.99, P = 0.014]. Conclusions:Compared with 2-dimensional intraluminal post-loading radiotherapy, 3-dimensional intraluminal post-loading radiotherapy improves the efficacy of patients with intermediate and advanced cervical cancer, reduces the occurrence of acute and chronic radiation enteritis and radiation cystitis, reduces the adverse reactions of patients.
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ObjectiveTo investigate the role of CD4+ CD25+ regulatory T cells(Treg) in peripheral blood and intestinal endotoxin (ET) in liver injury of rat severe acute pancreatitis (SAP).MethodsSixty male Wistar rats were randomly allocated into sham operation group(SO group) and severe acute pancreatitis group(SAP group).The rats in SAP group recevied the injection of Sodium Taurocholate(NaTc) into their far-end of bile-pancreatic duct and were sacrificed in 3-,6-and 12-hour,serum amylase(AMY) and alanine aminotransferase(ALT) determined by full-automatic biochemistry instrument,limulus reagent method is used to determine ET content in plasma,the proportion of Treg among peripheral lymphocytes was determined by Flow Cytometry(FCM),HE stain is used to observe pathological changes in liver and pancreas,the protein of Foxp3 activity was evaluated by immunohistochemistry staining,and the relationships between these indicators were analyzed using Pearson correlation analysis test.ResultsHistopathologic examination and the level of ALT revealed the occurrence of pancreatic inflammation and pathological changes of liver in SAP group.The percentage of Treg in SAP groups significantly increased at 3 h(2.26％ ±0.32％),6 h(2.36 ％ ±0.48％)and 12 h(2.80％ ±0.35％) comparing to the SO groups(P＜0.01) ; plasma ET levels compared with the SO group was statistically significant (P＜ 0,01 ),and 12 h (0.85 ± 0.11) compared to,3 h (0.74±0.11) and 6 h (0.78-±-0.07) was no significant difference (P＞0.05).The expression of Foxp3 protein on the livers were upregulated markedly.Pearson correlation analysis teat showed that quantities of Treg were positively proportional to the levels of ET(r=0.89,P＜0.01) after liver injury of SAP.ConclusionsSAP may lead to liver injury and the high plasma levels of ET and Treg in peripheral blood may play an important role in liver injury of SAP.