RESUMO
OBJECTIVE: To characterize the pharmacokinetics of a single dose of 2.5 mg fondaparinux sodium in Chinese patients after thoracic surgery. METHODS: Thirteen patients were enrolled in the study and were given a single dose of 2.5 mg fondaparinux sodium via a subcutaneous injection. Plasma concentrations of fondaparinux sodium were measured throughout a 24 h period. The pharmacokinetic analysis was performed using WinNonlin software. RESULTS: The following pharmacokinetic parameters were derived; t1/2(7.92 ± 3.13) (4.21-15.89) h, tmax(2.52 ± 0.93) (1.38-4) h, p-1 (0.73 ± 0.18) (0.45-1.02) mg · L-1, AUClast(6. 56 ± 2.19) (3.07-9. 75)mg · h · L-1, Vz/F(3.54 ± 1.00) (2.24-5.73) L, CL/F(0.34 ± 0.14) (0.16-0.63) L · h-1, and MRTlast (6.98 ± 2.1) h. The pearson correlation coefficient, r was 0.7283(P = 0.005) between the serum creatinine(Scr) and mean residence time(MRTlast) of fondaparinux. CONCLUSION: The disposition of fondaparinux is highly variable in patients. A statistical significant correlation between Scr and MRTlast of fondaparinux was observed. Fondaparinux sodium administered by intravenous injection is well tolerated in patients.
RESUMO
AIM:To determine chlorogenic acid and hesperidin in Qingrehuoxue Mixture (Herba Artemisiae Scopariae, Pericarpium Citri Reticulatae, etc.) at the same time by HPLC. METHODS: A gradient method was set up with eluent of acetonitrile-water (0.4% phosphric acid). The detection wavelength of hesperidin was set at 283 nm, the detection wavelength of chlorogenic acid at 325 nm. RESULTS: The average recovery of two components were all above 95%, RSD was no more than 1.6%. The calibration curve was linear. CONCLUSION:The method is accurate and reliable with good reproducibility.