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1.
Chinese Journal of Medical Genetics ; (6): 272-276, 2005.
Artigo em Inglês | WPRIM | ID: wpr-321108

RESUMO

<p><b>OBJECTIVE</b>To investigate the effect of interaction between paranoxonase 1 (PON1)gene polymorphism and ATP-binding cassette transporter 1 (ABCA1) genetic variation on serum lipid level.</p><p><b>METHODS</b>Polymerase chain reaction-restricted fragments length polymorphism was used to determine PON1 A/B192 and ABCA1R219K genotype of 1019 subjects, including 680 patients with strokes and 339 healthy individuals as controls.</p><p><b>RESULTS</b>No significant association between A/B192 genotype and any of the lipid measurements was detected. The levels of HDL-C in the subjects with RR, RK and KK genotypes showed a significant upward tendency respectively (P < 0.05); the levels of their triglyceride (TG) tended downward respectively, but there were no significant differences between them. The relationship between R219K genotype and serum lipid level was modified by A/B192 genotype. The levels of HDL-C in the subjects with AA/RR genotype and BB/KK genotype [(1.41 +/- 0.40) mmol/L, (1.41 +/- 0.39) mmol/L] were significantly different from that in the subjects with BB/RR genotype [(1.28 +/- 0.36) mmol/L] (P < 0.05).</p><p><b>CONCLUSION</b>The result exhibited an interaction of PON1 A/B192 and ABCA1 R219K on serum lipid level.</p>


Assuntos
Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Transportadores de Cassetes de Ligação de ATP , Genética , Arildialquilfosfatase , Genética , Sequência de Bases , Genótipo , Lipídeos , Sangue , Reação em Cadeia da Polimerase , Polimorfismo Genético , Genética , Análise de Sequência de DNA
2.
Chinese Journal of Epidemiology ; (12): 533-536, 2005.
Artigo em Chinês | WPRIM | ID: wpr-331841

RESUMO

<p><b>OBJECTIVE</b>To investigate the relationship between apolipoprotein E (ApoE) gene polymorphism and serum lipid profile.</p><p><b>METHODS</b>Polymerase chain reaction-restricted fragments length polymorphism (PCR-RFLP) was used to determine ApoE genotype on 1452 subjects including 1101 cases with cardio cerebrovascular disease including 379 cases with cerebral infarction, 313 cases with cerebral hemorrhage, 257 cases with coronary heart disease, and 152 cases with other types and on 351 healthy controls.</p><p><b>RESULTS</b>After adjusting for age, sex and BMI, the subjects with ApoE4 carriers had significantly higher levels of total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C) and ApoB than those with ApoE2 carriers and ApoE3/3 (P < 0.05), and higher level of triglyceride(TG) than those with ApoE3/3 (P < 0.05), while the subjects with ApoE2 carriers had significantly higher levels of high density lipoprotein-cholesterol (HDL-C) than those with ApoE4 (P < 0.05). The effects of ApoE polymorphism exhibited similarity in different sex and age of subjects. Linear regression analysis showed that unlike ApoE3/3, the HDL-C level in ApoE2 carriers tend upward with age (beta = 0.178, P = 0.015), significantly higher than ApoE4 carriers and ApoE3/3 in the cohort of 65-74 years (P < 0.05). The level of TC and TG in ApoE4 carriers had a tendency of downward with age (p = -0.179, P = 0.009; beta = -0.147, P = 0.032).</p><p><b>CONCLUSION</b>ApoE gene polymorphism affected profile of blood lipids and the effects were found in different sex and age. The degrees of effects related to ApoE2 carriers and ApoE4 carriers to blood lipid level seemed to be related to age.</p>


Assuntos
Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Adulto Jovem , Fatores Etários , Apolipoproteínas E , Genética , Estudos de Casos e Controles , Genótipo , Lipídeos , Sangue , Polimorfismo Genético , Fatores Sexuais
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