Classification and clinical roles of immune related-biomarkers in sepsis / 中国小儿急救医学

Biomarkers of sepsis play critical roles in diagnosis, early recognition of organ dysfunction, risk stratification, prognostication, and therapeutic strategy.The dysregulated inflammatory response is reflected drastic changes in pathogen-associated molecular patterns and damage-associated molecular patterns, presented the changes of gene expression and epigenetic modification, metabolic reprogramming and immune dysfunction of immune cells.Sepsis is classified into hyperinflammatory phenotype and immunosuppression phenotype.Biomarker exploration is also conductive to understand the heterogeneity of sepsis and developing the individualized treatment strategies.This issue focused on novel immune-associated biomarkers for prognostic prediction that could be useful to optimize patient management.

Diagnosis and treatment of heterotopic pancreas at the angular notch of stomach misdiagnosed as gastric stromal tumor / 中华消化外科杂志

Heterotopic pancreas is usually defined as a presence of pancreatic tissue without any anatomical or vascular continuity,and is one of the congenital and rare diseases.The clinical manifestations are easily confused with other gastrointestinal diseases,and conventional endoscopic examination cannot provide a clear preoperative diagnosis,therefore heterotopic pancreas is often misdiagnosed.It is very important to distinguish heterotopic pancreas and other digestive diseases.In this article,the clinical characteristics,differential diagnosis and treatment method of one patient with heterotopic pancreas who was admitted to the Affiliated Hospital of Chengde Medical College in March 2014 were analyzed.

Effect of subculture at logarithmic phase on kinetics of cell cultures of Taxus chinensis var. mairei / 中草药

Object To solve the problem of low growth rate an d metabolism level in Taxus chinensis var. mairei (Lem?e et L?vl.) Cheng et L. K. Fu Methods Cells on logar it hmic phase (20 d) and stationary phase (30 d) were subcultured individually. Th euptake of carbohydrate, nitrogen and phosphate from the medium was examined, th e growth rate of Taxus cell and the synthesis of taxol were anal y zed too during the whole growth period Results The Taxus cell subcultured at logarithmic phase uptook carbohydrate and nit rate earlier than that subcu ltured at stationary phase. The special growth rate of the former was 1.5 folds of that of the latter. The production rate of taxol was increased by nearly 4 ti m es Conclusion Subculturing at logarithmic phase will benefi t the biomass accumulation and the taxol synthesis