RESUMO
Objective To explore whether alcohol promotes the development of breast cancer in TA2 mice and the possible potential mechanism. Methods Thirty-two 6-8-week old nulliparous female TA2 mice were randomly divided into control and ethanol-exposure groups, 16 mice in each group. The mice of the ethanol-exposure group were given 2%ethanol in drinking water, and the mice of control group received regular drinking water. Serum ethanol concentration in the TA2 mice was measured using an ANALOX AM1 alcohol analyzer. The incidence of breast cancer, tumor growth rate and tumor size of the ethanol-exposure and control groups were observed and compared. The estrogen levels of the two groups was detected by enzyme-linked immunosorbent assay ( ELASA) . Results Compared with the control group, the tumor for-mation rate of spontaneous breast cancer in the alcohol-exposure group was significantly increased (62. 5% vs. 43. 75%, P<0. 05), the average number of days of tumor formation was shortened (285 days vs. 335 days, P<0. 05), the tumor weight and volume were increased but not significant ( P>0. 05 ) , and the level of estrogen in the ethanol-exposure mice was significantly higher than that in the control group ( P>0. 05 ) . Conclusions Alcohol promotes the tumorigenesis of spontaneous breast cancer in TA2 mice, which may be associated to the increase of estrogen levels.
RESUMO
Objective To analyze the clinical and pathological features of chil dren's periorbital pilomatricoma.Methods The clinical and pathological data of 46 children patients who were diagnosed as periorbital pilomatricoma and underwent surgical treatment between February 2012 and February 2017 were analyzed.Results Of the 46 patients,18 males and 28 females (male:female =l.00:1.56),lesion location of superciliary arch was observed in 26 patients (56.5％),upper eyelid was in 18 patients(39.1％),and the lower eyelid in 2 patients(4.3％).Light microscope was used for pathological examination and the results showed that pilomatricoma was composed of two major cells,and they were basaloid cells and shadow cells.There were 36 patients presenting calcification,25 patients with inflammatory cell infiltration,and 24 patients with multinucleated giant cells.Furthermore,no recurrence or malignant transformation occurred in these patients after surgery.Conclusion Pilomatrixoma presents typical clinical and pathological feature,and it is not uncommon for children patients with periorbital pilomatricoma,so the clinical characteristics of the pilomatricoma and differential diagnosis of the periorbital tumors is important to improve the diagnostic accuracy.
RESUMO
Objective To explore whether alcohol promotes the development of breast cancer in TA2 mice and the possible potential mechanism. Methods Thirty-two 6-8-week old nulliparous female TA2 mice were randomly divided into control and ethanol-exposure groups, 16 mice in each group. The mice of the ethanol-exposure group were given 2%ethanol in drinking water, and the mice of control group received regular drinking water. Serum ethanol concentration in the TA2 mice was measured using an ANALOX AM1 alcohol analyzer. The incidence of breast cancer, tumor growth rate and tumor size of the ethanol-exposure and control groups were observed and compared. The estrogen levels of the two groups was detected by enzyme-linked immunosorbent assay ( ELASA) . Results Compared with the control group, the tumor for-mation rate of spontaneous breast cancer in the alcohol-exposure group was significantly increased (62. 5% vs. 43. 75%, P<0. 05), the average number of days of tumor formation was shortened (285 days vs. 335 days, P<0. 05), the tumor weight and volume were increased but not significant ( P>0. 05 ) , and the level of estrogen in the ethanol-exposure mice was significantly higher than that in the control group ( P>0. 05 ) . Conclusions Alcohol promotes the tumorigenesis of spontaneous breast cancer in TA2 mice, which may be associated to the increase of estrogen levels.
RESUMO
Objective To analyze the clinical and pathological features of chil dren's periorbital pilomatricoma.Methods The clinical and pathological data of 46 children patients who were diagnosed as periorbital pilomatricoma and underwent surgical treatment between February 2012 and February 2017 were analyzed.Results Of the 46 patients,18 males and 28 females (male:female =l.00:1.56),lesion location of superciliary arch was observed in 26 patients (56.5％),upper eyelid was in 18 patients(39.1％),and the lower eyelid in 2 patients(4.3％).Light microscope was used for pathological examination and the results showed that pilomatricoma was composed of two major cells,and they were basaloid cells and shadow cells.There were 36 patients presenting calcification,25 patients with inflammatory cell infiltration,and 24 patients with multinucleated giant cells.Furthermore,no recurrence or malignant transformation occurred in these patients after surgery.Conclusion Pilomatrixoma presents typical clinical and pathological feature,and it is not uncommon for children patients with periorbital pilomatricoma,so the clinical characteristics of the pilomatricoma and differential diagnosis of the periorbital tumors is important to improve the diagnostic accuracy.