Chemical Constituents from Buddleja officinalis and Their Inhibitory Effects on Nitric Oxide Production

Bioactivity-guided fractionation of a methanolic extract of Buddleja officinalis led to the isolation of two monoterpenes, crocusatin M (1), crocusatin C (2), a flavonoid, acacetin (3), three lignans, lariciresinol (4), pinoresinol (5), and syringaresinol (6), and two triterpenoidal saponins, mimengoside B (7) and songarosaponin A (8). The structures of isolates were identified based on 1D-, 2D-NMR, and MS data analysis. All isolates were tested for their inhibition on LPS-induced NO production in RAW 264.7 cells. As a result, mimengoside B (7) and songarosaponin A (8) showed a mild inhibitory activity of NO production.

Buddlejaceae endémicas del Perú

La familia Buddlejaceae es reconocida en el Perú por presentar dos géneros y 16 especies (Norman, 2000; Ulloa Ulloa et al., 2004), principalmente arbustos. En este trabajo reconocemos dos especies endémicas en el género Buddleja. Estos taxones endémicos se encuentran en las regiones Mesoandina, Puna Húmeda y Seca y Páramo, entre los 2650 y 3900 m de altitud. Una de estas dos especies se encuentra representada dentro del Sistema Nacional de Áreas Naturales Protegidas por el Estado.

The Buddlejaceae are represented in Peru by two genera and 16 species (Norman, 2000; Ulloa Ulloa et al., 2004), mainly shrubs. Here we recognize two endemic species, both in the genus Buddleja. These endemic taxa are found in Mesoandean, Humid and Dry Puna, and Paramo regions, between 2650 and 3900 m elevation. One species has been registered within the Peruvian parks system.