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1.
Mem. Inst. Oswaldo Cruz ; 113(7): e180050, 2018.
Artigo em Inglês | LILACS | ID: biblio-894943

RESUMO

Cryptococcosis diagnosis has been recently improved by the use of rapid cryptococcal antigen testing with lateral flow assays, which have proved sensitive and specific. Using "test and treat" screening strategies for cryptococcal disease with these tests has been showed effective in reducing cryptococcal meningitis (CM) in HIV-infected patients. Recommended induction, consolidation, and maintenance therapeutic strategy for CM is widely unavailable and/or expensive in low and middle-income settings. New therapeutic strategies, mostly using reduced duration, have recently shown acceptable outcome or are currently tested. Diagnostic and therapeutic guidelines for cryptococcal disease in limited resources countries are undergoing a paradigmatic shift.


Assuntos
Humanos , Meningite Criptocócica/diagnóstico , Infecções Oportunistas Relacionadas com a AIDS/tratamento farmacológico , Criptococose/tratamento farmacológico , Testes Imunológicos , Quimioterapia Combinada
2.
Korean Journal of Stroke ; : 78-81, 2012.
Artigo em Coreano | WPRIM | ID: wpr-14868

RESUMO

Cryptococcosis is a global invasive mycosis associated with significant morbidity and mortality. Fever, headache and vomiting are common clinical presentations of the cryptococcal meningitis. But ischemic stroke and cranial nerve impairment are rare neurologic complications. We report a case of cryptococcal meningoencephalitis presenting as cerebral infarction and multiple cranial nerve palsies.


Assuntos
Infarto Cerebral , Doenças dos Nervos Cranianos , Nervos Cranianos , Criptococose , Febre , Cefaleia , Meningite Criptocócica , Meningoencefalite , Acidente Vascular Cerebral , Vômito
3.
Mem. Inst. Oswaldo Cruz ; 102(7): 777-784, Nov. 2007. ilus, tab
Artigo em Inglês | LILACS | ID: lil-470343

RESUMO

Despite highly active anti-retroviral therapy, cryptococcal meningoencephalitis is the second most prevalent neurological disease in Brazilian AIDS patients, being frequently a defining condition with several episodes. As knowledge of Cryptococcus neoformans isolates in the same episode is critical for understanding why some patients develop several episodes, we investigated the genotype characteristics of C. neoformans isolates in two different situations. By pulsed field gel electrophoresis and random amplifield polymorphic DNA analysis, 54 isolates from 12 patients with AIDS and cryptococcosis were analyzed. Group 1 comprised 39 isolates from nine patients with a single episode and hospitalization. Group 2 comprised 15 isolates from three patients with two episodes and hospitalizations. Except for three patients from group 1 probably infected with a single C. neoformans isolate, the other nine patients probably were infected with multiple isolates selected in different collection periods, or the infecting isolate might have underwent mutation to adapt and survive the host immune system and/or the antifungal therapy. However, the three patients from group 2 presented genetic diversity among isolates collected in both hospitalizations, possibly having hosted the initial isolate in both periods. These data, emphasize that Cryptococcus diversity in infection can contribute to strategies of treatment and prevention of cryptococcosis.


Assuntos
Humanos , Infecções Oportunistas Relacionadas com a AIDS/microbiologia , Cryptococcus neoformans/genética , Variação Genética , Meningoencefalite/microbiologia , Doença Aguda , Brasil , Cryptococcus neoformans/isolamento & purificação , DNA Fúngico/genética , Eletroforese em Gel de Campo Pulsado , Genótipo , Técnicas de Tipagem Micológica , Técnica de Amplificação ao Acaso de DNA Polimórfico
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