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Objective To explore the anti-islet cells in patients with chronic autoimmune thyroiditis. Methods Glutamate decarboxylase antibody was quantitatively detected by ELISA method, and the frequency of anti-GAD antibody in children with chronic autoimmune thyroiditis was compared with that in healthy control group. Results Of the 41 patients with chronic autoimmune thyroiditis, 4 (9.8%) were GAD antibody positive. The positive rate of GAD in chronic autoimmune thyroiditis group was significantly higher than that in the control group (P<0.05). Conclusion This study found that GAD antibody positive rate in patients with autoimmune thyroiditis was significantly higher. Our findings supported the concept of autoimmune thyroid disease patients who may develop into type 1 diabetes in future life.
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Objective To explore the anti-islet cells in patients with chronic autoimmune thyroiditis. Methods Glutamate decarboxylase antibody was quantitatively detected by ELISA method, and the frequency of anti-GAD antibody in children with chronic autoimmune thyroiditis was compared with that in healthy control group. Results Of the 41 patients with chronic autoimmune thyroiditis, 4 (9.8%) were GAD antibody positive. The positive rate of GAD in chronic autoimmune thyroiditis group was significantly higher than that in the control group (P<0.05). Conclusion This study found that GAD antibody positive rate in patients with autoimmune thyroiditis was significantly higher. Our findings supported the concept of autoimmune thyroid disease patients who may develop into type 1 diabetes in future life.
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Stiff man syndrome is a rare neurological condition characterized by progressive muscle stiffness and rigidity, painful spasm of axial and limb muscles with impairment of walking. Because its etiology is still unclear, diagnosis is based on typical clinical manifestations. Benzodiazepines are known as effective drug for the treatment of symptoms. We report a case of 39-year-old female patient who has suffered from rigidity of trunk, back pain, gait disturbance and depressive mood for 18 months. She was diagnosed as stiff man syndrome and successfully treated with medications such as diazepam, clonidine, baclofen.
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Adulto , Feminino , Humanos , Dor nas Costas , Baclofeno , Benzodiazepinas , Clonidina , Diazepam , Extremidades , Marcha , Músculos , Espasmo , Rigidez Muscular Espasmódica , CaminhadaRESUMO
Objective To investigate the pathogenesis of hepatogenic diabetes.Methods The fasting and 2-hour postprandial plasma glucose,fasting sertum insulin,glutamate decarboxylase antibody,insulin release index (IRI)and insulin sensitivity index(ISI)Was determined and analyzed in 135 liver cirrhosis patients.Results The incidence of hepatogenic diabetes wag 39.3%(53/135)in liver cirrhosis patients.The incidence of hepatogenic diabetes in post hepatitis C liver cirrhosis patients(53.3%.16/30)was muchh igher than that in post hepatitis B liver cirrhosis patients(37.1%,26/70)and alcohofic liver cirrhosis patients(31.4%.11/35)(P＜0.01).The fasting serum insulin,IRI and the positivity rate of glutamate decarboxylase antibody was much higher in hepatogenic diabetes than that in controls(P＜0.01),and ISl was much lower than that in controls(P＜0.01).Conclusions The development of hepatogenic diabetics is relsted with the etiological factor of liver cirrhosis.Besides impairment of the hepatocellular function and insulin resistance,viral infection and immunologic derangement and so on results in impairment of beta cell of islet function.Relative or absolute deficiency of insulin secretion is an important influential factor in the development of hepatogenic diabetics.
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Objective To compare the prevalence of microvascular and macrovascular complications between adult latent autoimmune diabetes(LADA)and type 2 diabetic subjects.Methods A cross-sectional study was performed in 203 LADA(GADA positive)and 203 T2DM(GADA negative)subjects matched with age,gender and duration as well as family history of diabetes.Parameters of microvascular(albuminuria、eyeground microscopy or fundus fluorescence photography,electromyogram)and macrovascular complications(electrocardiogram,blood pressure,blood lipid,body mass index)as well as blood sugar were compared.Results ①Microvascular complications:Compared with T2DM,LADA cases showed higher prevalence of diabetic nephropathy(39.9%vs.28.6%,P＜0.05)and similar prevalence in diabetic neuropathy and retinopathy(P＞0.05).②Macrovascular complications:LADA cases presented lower prevalence of hypertension(38.9%vs.55.7%,P＜0.01),lower prevalence of metabolic syndrome (33.0%vs.45.3%,P＜0.01＝,but similar orevalence of coronarv heart disease (CHD) and erebral infarction(CVD)(P＞0.05).Conclusion LADA patients present less metabolic syndrome,hypertension and more diabetic nephropathy compared with T2DM.