Muerte súbita intrahospitalaria luego de infarto agudo de miocardio en Cuba en los últimos tres años. Análisis de registros institucionales / Sudden intra-hospital death after acute myocardial infarction in Cuba in the last three years. Analysis of institutional records

Resumen Objetivo: Analizar el comportamiento de posibles causas predisponentes de muerte súbita (MS) intrahospitalaria luego de un infarto agudo de miocardio (IMA) en registros cubanos. Material y método: Se realizó una búsqueda de registros clínicos de pacientes con IMA en Cuba en las bases de datos de revistas nacionales, Scientific Library On-line (ScieLO) y Medline. Se priorizaron los artículos publicados desde 2016 para ser incluidos. Se definió como muerte súbita aquélla secundaria a arritmias ventriculares malignas (TV y FV), así como los pacientes con rotura cardíaca y actividad eléctrica sin pulso o asistolia como forma de presentación. Con posterioridad se evaluó la relación de este parámetro con la aparición de muerte súbita en 710 pacientes del Registro de Síndromes Coronarios Agudos (RESCUE). Resultados: En el contexto extrahospitalario, más de la mitad de las muertes súbitas cardíacas son secundarias a un infarto agudo de miocardio. En el hospital, la mortalidad en Cuba por IMA es homogénea. Sólo los centros con intervencionismo coronario escapan a este fenómeno. Aunque no del todo letales, las arritmias ventriculares malignas se relacionan con un peor pronóstico y su prevalencia no es homogénea en los registros revisados. Conclusiones: La muerte súbita luego de infarto agudo de miocardio será aún en Cuba una de las principales causas de muerte en los pacientes de fase aguda.

Abstract Objective: To analyze possible predisposing causes of in hospital sudden cardiac death (SCD) after an acute myocardial infarction (IMA) in Cuban registries. Material and methods: A search of clinical records of patients with IMA in Cuba was performed in the databases of national journals, Scientific Library On-line and Medline. Those articles published since 2016 were prioritized for inclusion. Sudden death is defined as that secondary to malignant ventricular arrhythmias (ventricular tachycardia, ventricular fibrillation) as well as patients with cardiac rupture with pulseless electrical activity or asystole as a form of presentation. Subsequently, the relationship of this parameter with the occurrence of sudden death was evaluated in 710 patients from the Registry of Acute Coronary Syndromes (RESCUE). Results: In the out-of-hospital setting, more than half of SCD are secondary to an IMA. Once in the hospital, mortality in Cuba from IMA is homogeneous. Only centers with coronary interventionism escape this phenomenon. Although not totally lethal, the presence of malignant ventricular arrhythmias is associated with a worse prognosis and its prevalence is not homogeneous in the reviewed records. Conclusions: Sudden death after IMA will continue to be one of the main causes of death of patients in the acute phase in Cuba.

Phytochemical To Interact With Nls Binding Site On Ima3 To Inhibit Importin Α/Β1 Mediated Nuclear Import Of Sars-Cov-2 Cargo

Objective: Ivermectin is an FDA-approved, broad-spectrum anti-parasitic agent. It was originally identified as an inhibitor of interaction between the human 29 immunodeficiency virus-1 (HIV-1) integrase protein (IN) and the Importin (IMP) α/β1 30 heterodimers, which are responsible for IN nuclear import. Recent studies demonstrate that ivermectin is worthy of further consideration as a possible SARS-CoV-2 antiviral. Methods: We built the pathogen-host interactome and analyzed it using PHISTO. We compared Ivermectin and plant molecules for their interaction with Importin α3 (IMA3) using molecular docking studies. Results: A phytochemical ATRI001 with the lowest binding energy-7.290 Kcal/mol was found to be superior to Ivermectin with binding energy-4.946 Kcal/mol. Conclusion: ATRI001 may be a potential anti-SARS-CoV-2 agent; however, it requires clinical evaluation.

Effect of long non-coding RNA hit on imatinib resistance j in acute lymphoblastic leukemia sup-b15 cell line / 中国药理学通报

Aim To investigate the effect of long non-coding RNA (LncRNA) HIT on the resistance of ima-tinib (IM) in SUP-B15 cell line of acute lymphoblastic leukemia (ALL) and the related mechanisms. Methods SUP-B15 cells were treated with concentration gradient IM and saline as IMR and control groups. The lentivirus transfected LncRNA HIT shRNAl # and 2# vector in IMR group cells to knock down the HIT expression as IMR shHITl # and 2# group cells. CCK-8 assay was used to detect IM half-inhibitory concentration ( ICjo ). Fluorescence quantitative PCR (qPCR) was applied to detect the expression levels of LncRNA HIT, QKI, 0ct4 and Sox2 mRNA. Western blot was employed to detect the expression levels of QKI, 0ct4 and Sox2 protein. Results Compared with those in control cells, there was significantly higher IM ICjq, higher expression of LncRNA HIT, 0ct4 and Sox2, and lower expression of QKI in groups of IMR, IMR shHITl# and 2# cells. Compared with those in IMR cells, there was significantly lower IM IC∗, lower expression of LncRNA HIT, 0ct4 and Sox2, and higher expression of QKI in groups of IMR shHITl# and 2# cells. The difference was statistically significant (P < 0. 05). Conclusions LncRNA HIT can increase the expression of Sox2 and 0ct4 via inhibiting the expression of QKI protein, and mediating the formation of IM resistance in ALL cells.

Application progress in quantitative determination of myocardial blood flow and coronary flow re-serve by PET/CT / 中华核医学与分子影像杂志

Cardiac PET/CT can not only obtain high quality myocardial perfusion images, but also non-invasively quantify myocardial blood flow ( MBF ) to obtain absolute MBF and coronary flow reserve ( CFR) , which can objectively diagnose and evaluate coronary arterial circulation function in the early phase. Cardiac PET/CT can be used for early diagnosis of myocardial ischemia, risk stratification and prog-nosis evaluation in patients with ischemic heart disease ( IHD) and special group. The principle, character-istics and application progress of MBF and CFR quantitation by PET/CT are reviewed in this article.

Relationship between ischemia-modified albumin and coronary stenosis / 西安交通大学学报(医学版)

Objective To investigate the relationship between ischemia-modified albumin (IMA) and coronary artery stenosis in patients without myocardial infarction.Methods For this study we consecutively enrolled 345 patients who received coronary angiography (CAG).According to the results,the subjects were divided into coronary stenosis group (232 cases)and control group (113 cases)to investigate the the relationship of IMA and IMA/albumin (IMAr)with coronary stenosis.Results ① The levels of IMA and IMAr in coronary stenosis group were higher than those in control group (P＜0.001).② The IMA and IMAr were higher in single-branch and multi-branch lesion groups than in control group (P＜0.05),whereas there was no significant difference between single-branch lesion group and multi-branch lesion group (P＞0.05).③ In receiver operating characteristics curve analysis,the sensitivity of IMA and IMAr was 64.4% and 78.0%,respectively (AUC:0.653,0.705,P＜0.001)in predicting coronary stenosis.④ Multivariate logistic regression analysis showed that IMAr was an independent risk factor for coronary stenosis in patients without myocardial infarction (OR=73.05,P＜0.001).Conclusion IMA and IMAr are closely correlated with coronary stenosis and have a value in predicting coronary artery stenosis in patients without myocardial infarction.

Eficiência de detector de metais e barra magnética no controle de contaminações físicas / Efficiency of metal detector and magnetic bar in the control of physical contaminations

Dentre os três principais tipos de contaminações, a física, não menos importante que a química e biológica, deixa grandes dúvidas quando o assunto é metal. Qual a melhor forma de retê-los? A resposta certamente será obtida analisando a origem do risco, porém, o que implantar na linha de produção quando a dúvida é: detector de metais ou atrativo magnético? Neste artigo foi identificado que, para uma determinada situação de risco, nem a barra magnética nem o detector de metais reduzem os perigos a níveis aceitáveis. Para este estudo foram reunidos dados de uma barra magnética e dados do Serviço de Atendimento ao Cliente de uma empresa de confeitos durante 12 meses. Estes mesmos dados foram avaliados em comparação à eficácia de um detector de metais e em relação às leis vigentes no país. Desta forma foi identificado que, na empresa estudada, utilizar somente a barra magnética, apesar dos perigos não estarem dentro dos níveis aceitáveis, é mais viável pois apresentou melhores resultados que o detector de metais e não causa perdas por falsos rejeitos.(AU)

Among the three main types of contamination, physics, no less important than chemical and biological, leave bigs doubts when it comes to metal. What is the best way to retain them? The answer will certainly be obtained by analyzing the origin of the risk, but what to implant in the production line when the doubt is: metal detector or magnetic attraction? In this article it was identified that for a given risk situation the magnetic bar reduces the hazards to acceptable levels. For this study data was collected from a magnetic bar and customer service data in a confectionery company for 12 months.These same data were evaluated in comparison to the effectiveness of a metal detector and in relation to the laws in force in the country. In this way it was identified that in this confectionery company, only using the magnetic bar is enough to reduce the danger to acceptable levels

Changes and clinical significance of ischemic modified albumin in patients with polycystic ovary syndrome / 中华内分泌外科杂志

Objective To investigate the change of ischemia modified albumin (IMA) in polycystic ovary syndrome (PCOS) women,and to examine the relationship between IMA and metabolic disorder.Methods 31 PCOS women (PCOS group) and 28 age-and BMI-matched healthy women (control group) were recruited.Serum IMA levels and related biochemical indexes were compared between the two groups,and the correlation between IMA and each index was analyzed.Results Serum IMA level in PCOS group was significantly higher than that in the control group (P＜0.05).Correlation analysis showed that serum IMA levels were positively correlated with testosterone levels (r=0.57,P=0.03).Conclusion Serum IMA levels in PCOS patients are significantly elevated and closely related to testosterone,suggesting that oxidative stress may be involved in the pathogenesis and development of hyperandrogenemia.

Utilidad de la Ultrasonografía en el Abordaje del Nódulo Tiroideo / Usefulness of Ultrasonography in the Approach to the Thyroid Nodule

Introducción: La patología nodular tiroidea es una entidad clínica frecuente, con predominio de los casos benignos. La importancia de su estudio radica en descartar malignidad. La anamnesis y exploración física en ge-neral, tienen un bajo poder predictivo para diagnosticar malignidad. La ultrasonografía de tiroides constituye la técnica de imagen más sensible para detectar y caracterizar lesiones tiroideas. Sin embargo, ninguna de sus características por si sola es suficiente para diferenciar entre benignidad y malignidad; el Sistema de Datos y Reporte de Imágenes Tiroideas (TIRADS) agrupa estas característi-cas para diferenciar y transmitir de manera homogénea, los hallazgos encontrados y su riesgo de malignidad. La biopsia-aspiración con aguja fina, es el método más preciso, rentable y seguro en el estudio de los nódulos tiroideos. Objetivo: Analizar las características ultraso-nográficas, correlacionándolas con la pre-sencia de malignidad, evaluando la reprodu-cibilidad de la clasificación TIRADS.Conclusión: Dada la variabilidad de criterios ultrasonográficos, es importante adoptar el TI-RADS, de aplicación sencilla y práctica para optimizar el manejo del nódulo tiroideo.

Introduction: Nodular thyroid disease is a com-mon clinical entity, with a predominance of benign cases. The importance of the study is rule out malignancy. The anamnesis and phy-sical examination generally have low predicti-ve power for diagnosing malignancy. Thyroid ultrasonography is the most sensitive imaging technique to detect and characterize thyroid lesions. However, none of its characteristics is enough to differentiate between benignity and malignancy; The System Thyroid Repor-ting and Data Images (TIRADS) bring these features to differentiate and transmit evenly, the findings and the risk of malignancy. The biopsy fine needle aspiration is the most ac-curate, cost effective and safe method in the study of thyroid nodules.Objective: To analyze the ultrasonography features, correlating with the presence of ma-lignancy, evaluating the reproducibility of the TIRADS classification.Conclusion: Given the variability of ultraso-nography criteria, it is important to adopt the TIRADS, simple and practical application to optimize the management of thyroid nodule.

Study on the immunoregulatory and lethal effects of natural killer T cells on melanoma cells in vitro / 国际检验医学杂志

Objective To explore the immunoregulatory and lethal effects of natural killer T lymphocytes(NKTs) in vitro .Meth‐ods The mixed lymphocyte cultured(MLC) system was established ,in which the B16F10‐luc‐G5 cells were set as target cells ,the total lymphocyte cells were set as effector cells .(1)In the experiment on immunoregulatory effects ,NKT lymphocytes or CD4+CD25+ T lymphocytes were set as regulating cells ,there was three groups ,including the NKT group ,CD4+CD25+ T group and pure target cell control group .Otherewise ,the 1640 blank control group was set by only adding RPMI1640 solution .(2)In the ex‐periment on antitumor effects ,the NKT or natural killer(NK) lymphocytes were set as killer cells ,there was three groups ,inclu‐ding the NKT group ,NK group and pure target cell control group .Mixed culturing 24 ,48 and 72 hours ,the bioluminescence of target cells in MCL system was detected by using the in vivo imaging system .Results (1)In the experiment on immunoregulatory effects ,there were statistically significant differences in measured average photon numbers between NKT group ,CD4+ CD25+ T group and the two control groups(P<0 .05) .The statistically significant differences were also found in the NKT group between 24 hours and 72 hours (P<0 .05) .(2)In the experiment on antitumor effects ,there were statistically significant differences in meas‐ured average photon numbers ,when the NKT group and NK group were compared to the pure target cell control group(P<0 .05) . After culturing 24 and 72 hours ,statistically significant differences were found between NKT group and NK group(P<0 .05) .Con‐clusion The NKT cells could inhibit the lethal effects of lymphocyte cells on target cells ,and the inhibitory effects are changed by the length of culturing .Compared with the CD4+CD25+ T lymphocytes ,NKT lymphocytes have strongger regulatory effects .Addi‐tionally ,the NKT cells have lethal effects on target cells ,which might be weaker than that of NK cells .

Comparison of the value of MRS and MRI in diagnosis of primary epilepsy with hippocampal lesions / 中国基层医药

Objective To discuss Magnetic Resonance Spectroscopy(MRS) on the localization diagnosis of primary epilepsy patients with hippocampal lesions before operation.Methods 50 patients with idiopathic epilepsy (epilepsy group) and 32 healthy volunteers (healthy control group) were underwent Magnetic Resonance Imaging ( MRI) and MRS examination.Results ( 1 ) MRI showed that results of examination in the healthy control group were all normal.Epilepsy group of 38 cases were found abnormal in hippocampal area,and all patients were unilateral. 27 cases of them reduced with hippocampal volume, while signal abnormality was in 7 cases, 4 cases occurred simultaneously reduced with hippocampal volume,and therer was no obvious abnormal signals in 12 cases of patients with epilepsy of hippocampus volume and signal.( 2 ) MRS examination results:the healthy control group MRS were normal.50 epileptic patients in group MRS showed that hippocampal abnormalities.The epilepsy group NAA/( Cho+Cr) ,NAA/Cho,NAA/Cr were significantly lower than those of the healthy control group;epilepsy group disease side hippocampus NAA/(Cho+Cr),NAA/Cho,NAA/Cr values have different degrees of reduction,compared with the contralateral side,the value of t were 12.716,9.155,17.476,all P<0.01.(3)50 cases of epilepsy patients in the epilepsy group disease side compared with the contralateral side,the side of hippocampus NAA/disease ( Cho+Cr) , NAA/Cho,NAA/Cr values were decreased,the test values of t were 7.295,6.303,2.761,all P<0.01.(4)50 cases of operation patients underwent postoperative pathological examination of resected tissue,resection of neurons,tissue showed different degrees of reduction,microglia proliferation and neuronophagia phenomenon.Comparison of the posi-tive rate of MRS and MRI examination,χ2 =13.636,P<0.01.Conclusion Magnetic resonance spectroscopy analy-sis can play the important role in the evaluation of epilepsy surgery preoperative epilepsy,MRS examination for preop-erative diagnosis positive rate is high,the localization diagnosis with high reliability.

Clinical value of magnetic resonance diffusion weighted imaging and dynamic enhanced imaging in endome-trial carcinoma staging / 中国基层医药

Objective To study the value of magnetic resonance diffusion weighted imaging (DWI)and dynamic enhanced imaging (DCE)in endometrial carcinoma staging.Methods 200 cases with endometrial carcinoma were selected,DWI and DCE were given before operation.The diagnostic value of two kinds of examination methods for the diagnosis of endometrial carcinoma in general and basic level was compared.Results The overall accuracy of muscle invasion of magnetic resonance DWI was 91.5%(183 /200),which was significantly higher than 77.5%(155 /200)of magnetic resonance DCE,the difference was statistically significant (χ2 =11.231,P <0.05 ).The accuracy,sensitivity and positive predictive value of the magnetic resonance DWI superficial and deep muscular layer were significantly higher than those of the magnetic resonance DCE (χ2 =9.283,8.231,9.021,8.927,8.142, 9.405,all P <0.05).Compared with pathological results,Kappa value of magnetic resonance DWI was 0.807,Kappa value of magnetic resonance DCE was 0.587.Conclusion Magnetic resonance DWI compared with magnetic reso-nance DCE,the accuracy and sensitivity of the infiltration of endometrial carcinoma was higher.

Trends on oxidative stress and antioxidant status in fluoride affected areas in Kolar district, India.

Fluoride in cellular respiratory processes and its association in free radical generation are extensively studied. Cell permeability generates the oxidative stress through free radical species entry that sequentially affects the cellular biomolecules and cause toxic effects. Present study intended to determine the trend of oxidative stress and antioxidant status in the fluoride affected area that may raise the need for supplementation of antioxidants. Oxidative stress denoted in terms of ischemia modified albumin and antioxidants by vitamin C & total antioxidant capacity. Methods: Sixty subjects were divided into two groups. Group I (control) from fluoride unaffected areas (n=30) and group II subjects from fluoride affected area (n=30). Serum was assayed for Ischemia Modified Albumin (IMA), plasma for Total Antioxidant Capacity (TAC) and vitamin C. Results: The mean ± SD of IMA, TAC, and vitamin C of individuals subjected in fluoride affected areas are 2.403 ± 0.543, 210 mmol/l ± 82.2 and 0.62 mg/dl ± 0.23 respectively. The values were compared to individuals from fluoride unaffected areas have IMA (1.054 ABSU ± 0.851), TAC (312 mmol/l ± 62.1) and vitamin C (0.93 mg/dl ± 0.14) with P <0.001. Conclusion: The present study revealed that, individuals subjected to fluoride affected areas have more oxidative stress and decreased levels of antioxidant status indicates the risk of generation of free radicals intensity as a chief component of oxidative stress. This research outcome necessitates dietary supplementation of nutrient antioxidants to minimize the consequences of oxidative damage to vital biomolecules in fluoridated affected areas.

Evaluation of endothelial adaptation and parameters of oxidative stress in patients after hemodialysis sessions.

This work was focused on the evaluation of parameters of oxidative stress (lipid peroxidation, total thiol groups, non-protein thiol groups, polyphenols and ascorbate) and endothelial adaptation by determining the nitric oxide (NO), high-sensitive C-reactive protein (HS-CRP) and ischemia-modified albumin (IMA) of patients with chronic renal insufficiency submitted to hemodialysis. It was seen a depletion of glutathione, polyphenols and reduced ascorbate, combined with the increase of oxidized ascorbate and lipid peroxidation stress. In addition, was verified the increase of levels of IMA in the plasma. NO showed an evident endothelial protective role due to reduction of levels of HS-CRP, however, did not contribute to increase the levels of IMA. Based on the results, it can be concluded that the patients evaluated in this study presented a clinical situation of oxidative stress. A new study focusing on the prevention of oxidative stress using different experimental models with antioxidants is valuable to improve the life quality of these patients.

Effect of Pleurotomy During Internal Mammary Artery Harvest on Pulmonary Function.

Background: Pulmonary function after coronary artery bypass graft surgery using harvested Internal mammary artery(IMA) were assessed in this prospective case control Clinical study comparing two groups of Patients with or without pleurotomy. Method: we conducted this Study at National Institute of Cardiovascular Diseases (NICVD), Dhaka, in the Department of Cardiovascular Surgery.A total of 60 consecutive patients undergoing CABG with use of IMA between july 2005 to June 2007 were reviewed. Study population were divided into Group A (n=30,undergone CABG with pleurotomy during IMA harvestion).Group B (n=30,undergone CABG with intactpleura during IMA harvestion). Results: in lung function spirometry revealed FEV1 significantly decreased in group A than B (56.81±17.76% Vs 79.85±7.7%; p=0.035)and when FEV1correalated with inspiratory vital capacity the advantage of intact pleura were confirmed at 6th postoperative day (78.02 ±12.17; B, 82.08 ±11.72 p=0.045). Vital capacity was significantly decreased in-group A than B at 3 months postoperatively (A 88.79 ± 14.38%;B 98.11±30.25%; p=0.009), but not on 6th Postoperative day. Pleuropulmonary complication like atelectasis, pleural effusion insignificantly higher in groupA than B(16.7 %VS6.7%) and (10% vs. 6.7%)at 6th postoperative day but not at 3months postoperatively. Conclusions: These results demonstrate that pleurotomy during Internal mammary artery harvesting significantly deteriorated pulmonary function variably than intact pleura group of patients.

Diagnóstico y tratamiento de la angina inestable aguda e infarto miocárdico sin elevación del segmento ST / Diagnosis and treatment of acute unstable angina and myocardial infarction without ST segment rise

La angina inestable aguda y el infarto miocárdico sin elevación del segmento ST son dos grandes afecciones del síndrome coronario agudo. Su frecuencia se incrementa con los novedosos y rápidos procedimientos terapéuticos que mejoran la supervivencia del paciente coronario. La presente investigación expone las clasificaciones más actuales, la fisiopatología, las causas y sus mecanismos patogénicos, los hallazgos según la coronariografía y las categorías de riesgo según los elementos clínicos, enzimáticos y electrocardiográficos cuyos marcadores contribuyen al diagnóstico y al pronóstico de ambas dolencias. Se valoran los diagnósticos diferenciales, la conducta médica y el arsenal terapéutico disponible en los distintos estadios de la angina inestable aguda, del infarto, de la angina refractaria y de Prinzmetal. Finalmente se presenta un algoritmo que resume el tratamiento en el síndrome coronario agudo sin elevación del segmento ST

The acute unstable angina and the myocardial infarction without ST segment rise are two major affections of acute coronary syndrome. Its frequency is increases with the novel and fast therapeutical procedures improving the coronary patient survival. Present research shows the more current classifications, the pathophysiology, the causes and its pathogenic mechanisms, the findings according the coronarygraphy and the risk categories according to the clinical, enzymatic and electrocardiographic elements whose markers contributing to diagnosis and prognosis of both diseases. The differential diagnoses, the medical behavior and the therapeutical armamentarium available in the different stages of the acute unstable angina, of infarction, of refractory angina and or the Prinzmetal. Finally, an algorithm summarizing the treatment of the acute coronary syndrome without ST segment rise is presented

Comportamiento de la CK MB y la troponina T en el posoperatorio de cirugía cardiovascular, hospital Hermanos Amejeira / Behavior of the CK MB and tropinin T in the postoperative treatment of cardiovascular surgery, Hermanos Amejeira hospital

Debido a nuestro interés en el comportamiento de las enzimas miocárdicas durante el postoperatorio de cirugía cardiovascular se hace este trabajo, realizándose un estudio prospectivo en el hospital clínico quirúrgico “Hermanos Ameijeiras”, en el período de mayo 2006 – mayo 2008, tomándose como muestra un total de 50 pacientes, todos operados en nuestro servicio por una afección cardiovascular, de los cuales 35 pacientes (70) fueron hombres. El estudio se realizó mediante la revisión de las historias clínicas. Se encontró que el 66 de los pacientes tenían 2 o más factores de riesgo y que el 12 de nuestro universo tuvo IMA perioperatorio. El estudio enzimático mostró que tanto la CK MB como la troponina T se elevan desde las primeras horas en el IMAP, mientras que en los pacientes sin IMAP estas comienzan a decrecer desde la segunda muestra. Todos los pacientes fueron intervenidos electivamente. No hubo ningún fallecido.

This work was carried out because of our interest in the behavior of the myocardial enzymes during the postoperative treatment of cardiovascular surgery in which a prospective study was conducted in the Clinical Surgical Hospital “Hermanos Ameijeiras” in the period may 2006-2008. A sample of 50 patients was taken. All of them operated because of cardiovascular disease in our department. 35 patients (70) were men. The study was conducted by reviewing the medical histories. We found that 66 of patients had 2 or more risk factors and a 12 of our universe had perioperative IMA. The enzymatic study showed that the enzyme CK MB and Troponin T rise in the early hours in the IMAP whereas in patients without IMAP these begin to decrease from the second sample. All patients were operated electively. There were no deaths.

The thyrothymic trunk : a collateral vessel to the thyroid and the thymus.

An anomalous arterial trunk was seen arising from the brachiocephalic artery, which divided into five branches supplying the isthmus and the right lobe of the thyroid gland; remnants of the thymus gland; the sternoclavicular joints and the anterior and posterior aspects of the pericardium. Broadly speaking this artery fitted into the description of the thyroidea ima artery, but on defining its proper area of distribution, it was more appropriate to call it the Thyrothymic Trunk or the anterior mediastinal artery.

Electronic portal imaging device in the real-time correction of setup error in intensity modulated radiation therapy for nasopharyngeal carcinoma / 中华放射肿瘤学杂志

margin from CTV to PTV.

Perihematomal edema in acute intracerebral hemorrhage treated with hyperbaric oxygen / 中华物理医学与康复杂志

Objective To study the effect of hyperbaric oxygen (HBO) therapy on perihematomal edema in acute spontaneous intracerebral hemorrhage. Methods Sixty-three consecutive hospitalized patients with supraten-torial intracerebral hemorrhage were allocated to an HBO group (n = 30) or a control group (n = 33) at random. Routine therapies were used with both groups. The treatment group received in addition twenty consecutive daily ses-sions of HBO therapy beginning 3～5 d after onset. MRI brain scans were performed on the 5～7th and 25th day. Absolute edema volumes and relative edema volumes were measured from T2-weighted images. Apparent diffusion co-efficients (ADCs) of the edematous regions were calculated on diffusion-weighted images (DWI). Results There were no statistical differences between the two groups in terms of age, sex, blood pressure, NIHSS, hematoma posi-tion or volume. At the 5th～7th d, both absolute and relative edema volumes in the HBO group were smaller than in the controls (P≤0.05). Brain edema was still prominent at the 25th d. Absolute edema volumes, relative edema volumes and ADC values were all smaller in the HBO group at the 25th day compared with the controls (P≤0.05). Conclusion HBO therapy soon after intracerebral hemorrhage can lessen the severity and range of brain edema. E-dema persists after the onset of the disease, and HBO can reduce such delayed brain edema. HBO may benefit func-tional recovery from intracerebral hemorrhage by reducing perihematomal edema.

IMA-origin Lymph Node Metastasis in Left Colon Cancer

PURPOSE: Although an extended colon resection with high ligation of the inferior mesenteric artery (IMA) generally has been recommended as curative surgery for advanced left colon cancer (LCC), it shows little or no survival advantage over segmental resection with low ligation of IMA. The present study is to determine the risk factors associated with IMA-origin lymph-node (LN) metastasis and to clarify the implication of IMA-origin LN metastasis. METHODS: We examined the clinicopathological results of 200 cases of LCC. LN dissection was performed as follows: D2 en-bloc resection of the primary tumor, IMA-origin LN dissection, and paraaortic LN dissection. RESULTS: The incidence of IMA-origin LN metastasis of LCC was 4.5% (9 cases), and all cases involved sigmoid colon cancer. The independent risk factors of IMA-origin LN metastasis were four or more regional LN metastases (hazard ratio: 16.51, 95% confidence interval: 1.60~164.12) and a preoperative CEA level of greater than 6 ng/ml of (hazards ratio: 6.63, 95% confidence interval: 1.06~41.32). The incidence of IMA-origin LN metastasis among stage IIIC patients was 26.7%. Five of the 9 (55.6%) cases of IMA-origin LN metastasis had a concomitant paraaortic LN metastasis. CONCLUSIONS: The incidence of IMA-origin LN metastasis among patients with LCC was low; however, IMA-origin LN metastasis should be considered as a systemic metastasis.