Acne Severity Scoring Using Deep Learning / 대한피부과학회지

BACKGROUND: Acne is a chronic inflammatory disease of the pilosebaceous unit, mainly on the face. It can have various clinical manifestations and should be appropriately treated based on the severity. In Korea, the ‘Korea Acne Severity Rating System (KAGS)’ is a standardized index to determine the severity of acne according to specific Korean characteristics. However, the actual use of the KAGS in clinical settings has been limited. OBJECTIVE: We sought to analyze whether we could effectively measure acne severity using a deep learning algorithm, which is an image learning method. METHODS: Acne severity was classified into three levels of mild, moderate, and severe based on the KAGS, and learning and verification were performed using the CNN (Convolutional Neural Network), a deep learning technique. RESULTS: GoogLeNet's Inception-v3 algorithm showed the highest accuracy at 86.7%. CONCLUSION: This study confirmed that the use of a deep learning algorithm may facilitate the scoring of acne severity.

The Efficacy of Oral Isotretinoin (Roaccutane(R)) in the Treatment of Acne by Using the Korean Acne Grading System / 대한피부과학회지

BACKGROUND: Although oral isotretinoin is an effective established therapy for acne, Korean data related with this therapy is very limited. Moreover, there is no published data available on the efficacy of this drug that uses a grading system suitable for Korean acne patients. OBJECTIVE: The purpose of this study is to evaluate the efficacy of oral isotretinoin (Roaccutane?) by using the Korean Acne Grading System (KAGS) and the general satisfaction of patients in treating acne. METHODS: In this multicenter and prospective clinical study, 499 patients with acne, who visited at 5 dermatologic clinics during 11 months, were enrolled. The drug dosage was 0.2~1.0 mg/kg/day over 4 months. The efficacy assessment was performed at baseline and monthly after, with an acne grading based on the KAGS and the patient satisfaction questionnaire. RESULTS: Out of the 499 patients, 435 and 371 have completed the 3-month and 4-month treatments, respectively. After the 4-month treatment, the mean acne grades significantly decreased from 2.71 to 0.68, thus showing a 75.9% reduction in pretreatment scores. The mean patient satisfaction scores improved at the end of 4-month treatment, showing a 4.42 out of 5. CONCLUSION: In this paper, we describe the efficacy of oral isotretinoin by using the KAGS, which has not been previously reported in the Korean literature. Our results show that oral isotretinoin is an effective and satisfactory treatment modality for acnes of all grades in Korean patients, regardless of the dosage.

Topical Aminolaevulinic Acid-Photodynamic Therapy for the Treatment of Mild to Moderate Inflammatory Acne

BACKGROUND: Photodynamic therapy (PDT) using aminolevulinic acid (ALA) is a new technique. PDT is being studied extensively and is used in a variety of dermatology settings. OBJECTIVE: The purpose of this study was to evaluate the safety and efficacy of topical ALA-PDT in patients with mild to moderate inflammatory acne. METHOD: Ten patients were enrolled in a clinical trial to evaluate ALA-PDT with activation by intense pulsed light. They were given a 20% topical ALA photosensitizing agent that remained in contact with the skin for 60 minutes before irradiation. No additional treatment was provided after PDT. RESULTS: The Korean acne grading system was used for clinical assessment. Our results showed a statistically significant clinical improvement of the inflammatory acne at eight weeks after two sessions of treatment. Side effects such as slight discomfort, burning and stinging were reported during the irradiation. CONCLUSION: ALA-PDT is a safe and effective treatment modality for inflammatory acne.