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Objective To explore the change of thyroid hormones and leptin at hyperuricemia (HUA)/gout.Methods A total of 96 primary gouts,65 HUAs,and 59 healthy examiners was selected.Height,weight,blood pressure,renal function,serum uric acid(SUA),glucose,lipid profiles,insulin,thyroid hormones were measured after an overnight fast.Results (1) The prevalence of subhypothyriodism at gout and HUA was 7.29％ and 15.38％,respectively.They were higher than that at healthy subjects.(2) Body mass index (BMI),systolic blood pressure (SBP),triglyceride (TG),cholesterol (CHO),thyroid stimulating hormone (TSH),fasting insulin (FINS),homeostasis model assessment of insulin resistance (HOMA-IR),and serum leptin level were increased remarkably at gout/hyperuricemia relative to control group,whereas,free thyroid hormone (FT4) was decreased.(4) In the gout and hyperuricemia groups,TSH was used as the dependent variable for the linear multivariate regression analysis,the results showed that sex,age,BMI,SUA,FT4,HOMA-IR,and Leptin were included in the regression equation of TSH (βwere-0.27,0.832,0.946,0.198,-0.942,0.895,and 0.650,respectively).Conclusions The prevalence of subhypothyroidism in primary gout/hyperuricemia was increased.Female,age,BMI,SUA,FT4,HOMA-IR,and leptin were the independent risk factors.Insulin resistant and leptin played the media roles in the gout/HUA and hypothyroidism.
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Objective To investigate the therapeutic effect of Jianpi Zengshi Granules(JZG) for children anorexia(CA),and to observe its effect on serum orexin,leptin and neuropeptide Y(NPY) levels.Methods Sixty anorexia children were equally randomized into two groups: the treatment group received JZG and the control group received Jianwei Xiaoshi Tablets.The treatment lasted 4 weeks.The therapeutic effect was evaluated after treatment,and the changes of serum orexin,leptin and NPY levels were observed before and after treatment.Results The comprehensive therapeutic effect,effect on TCM syndromes,and effect on symptoms and signs such as appetite,food in-take volume and body weight in the treatment group were superior to those in the control group(P
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[Objective] To investigate the relationship between serum leptin level in chronic renal failure (CRF) and Qi or yang deficiency syndrome of spleen and kidney. [Methods] Thirty-eight cases of CRF and 16 healthy subjects as control were enrolled in this study. The CRF patients were classified as Qi /yang deficiency syndrome of spleen and kidney (pattern 1) and non-Qi/yang-deficiency syndrome of spleen and kidney (pattern 2). Serum leptin level was detected by enzyme-linked immunosorbent assay and nutrient parameters such as serum albumin (ALB), C-reation protein (CRP) and pre;ilbumin (preAlb) levels were also observed. The relationship of leptin level and nutrient parameters with Qi or yang deficiency syndrome of spleen and kidney was observed. [Results] The serum leptin level of pattern 1 was higher than that of pattern 2 ( P 0.05) . [ Conclusion ] Serum leptin may be the partial material base of Qi or yang deficiency syndrome of spleen and kidney and this is worthy doing further research. The uncertain relationship between nutrient parameters and Qi or yang deficiency syndrome of spleen and kidney may be due to the increase of type Ⅱ error which results from the small sample size.