RESUMO
Objective To investigate the effect of assisted excision of intrauterine progesterone (PR) on different hormone levels and expression of receptor in patients with adenomyosis.Methods Totally 84 patients with adenomyosis admitted in our hospital from January 2015 to June 2016 were randomly divided into control group and experimental group according to different treatment methods.In the control group,40 cases were treated with focal lesion 44 cases were treated with adenosine and progesterone sustained-release system.The therapeutic effect was evaluated by the expression of estrogen and progesterone receptor in the two groups after treatment.The therapeutic effects were compared between the two treatment methods The advantages and disadvantages.Results VAS and PBAC score before and after treatment in the two groups were compared.The VAS of the two groups before and after treatment was no significant difference and VAS grading had no difference(P ＞0.05).1,3 and 6 months after treatment in the two groups VAS and VAS grading were different in different degree,P ＜ 0.05.There was no significant difference in the ER and PR levels between the control group and the experimental group before and after treatment (P ＞ 0.05).The levels of ER and PR in the endometrium were significantly lower than those in the control group (P ＞ 0.05).The level of ER and PR in the control group was significantly higher than that in the control group (P ＜ 0.05),and there was no significant difference between the control group and the experimental group (P ＞ 0.05).The levels of FSH and LH in the two groups were significantly lower than those before treatment (P ＜ 0.05),and the difference was significant (P ＜ 0.05).The difference of the levels of FSH between the two groups was statisticaliy significant (P ＜ 0.05),and PGF2α and TXA2 in patients,the two groups were lower than before treatment,and the difference was statistically significant(P ＜ 0.05).Conclusion Ectopic pregnancy and progesterone assisted resection of adenocarcinoma has a good effect on adenomyosis.It can not only improve the clinical symptoms,but also improve the expression of estrogen and progesterone.It is suitable for clinical application.
RESUMO
OBJECTIVE:To compare the effects of prophylactic application of 3 different antibiotics on prognosis in patients underwent breast lesion resection. METHODS:1 066 patients with breast lasion resection from 12 hospitals of Shaanxi province were divided into trial group(360 cases),control group A(352 cases)and control group B(354 cases)according to random num-ber table. Trial group was given first generation cephalosporin cefazolin;control group A was given second generation cephalospo-rin cefuroxime;control group B was given third generation cephalosporin cefoperazone sodium and tazobactam sodium. The dosage regimens of 3 groups were as follows:relevant drug 2 g added into 0.9%Sodium chloride injection 100 ml,ivgtt,0.5 h before sur-gery,medication course≤24 h after surgery in trial group. Those indexes of 3 groups were observed,such as post-operative ADR, incision healing,infection,hospitalization duration,phamaceutical costs per capita. RESULTS:There was no statistical signifi-cance in the rate of incision healing and the rate of post-operative infection among 3 groups(P>0.05). The incidence of post-opera-tive ADR,hospitalization duration and phamaceutical costs per capita in observation group were significantly lower or shorter than in control group A and B,with statistical significance(P<0.05). CONCLUSIONS:Cefazolin is better than cefuroxime and cefo-perazone sodium and tazobactam sodium to reduce the postoperative adverse reaction,antibiotics cost per capita and hospital drug cost per capita,shorten the hospitalization duration.
RESUMO
Objective To compare the efficacy of ultrasound ablation and laparoscopic lesion resection with uterine artery liga-tion in treating adenomyosis .Methods By using the prospective ,non-randomized controlled clinical study method ,the adenomyosis patients with clinical symptoms and requiring reserved uterus in our hospital from March 2011 to June 2012 were treated by the ul-trasound ablation technique(ultrasound ablation group ,40 cases) and the laparoscopic lesion resection with uterine artery ligation (operation group ,38 cases) .The menstrual blood volume ,dysmenorrhea and treatment satisfaction in postoperative1 ,3 ,6 months were compared between the two groups .Results The menstrual blood volumes in postoperative 1 ,3 ,6 months in the two groups were decreased significantly(P0 .05) .Conclu-sion The two methods of the ultrasound ablation technique and the laparoscopic lesion resection with uterine artery occlusion for treating adenomyosis could significantly reduce the menstrual blood volume ,improve dysmenorrheal and obtain higher satisfaction . Both can achieve the same therapeutic effect .