RESUMO
Objective To observe the curative effect and safety of interventional therapy of uterine fibroids using Embosphere and Pingyangmycin lipiodol emulsion.Methods The clinical data of 120 cases with uterine fibroids treated in our hospital were reviewed,and the patients were according to the different treatments given,divided into two groups (each with 60 cases).Patients in control group were treated with interventional therapy of Pingyangmycin lipiodol emulsion,while patients in the study group were given interventional therapy of Embosphere.The clinical efficacy and safety in the two groups were compared.Results The total efficiency in the study group was 93.33%,which was significantly higher than that in the control group (75.00%),and the difference was statistically significant (P<0.05).The comprehensive indexes after the treatment were improved in both groups compared with those before the treatment,and the improvement in the study group was significantly better than the control group (P<0.05,P<0.01).Besides,the total incidence of adverse effects in the study group was 11.67%,which was significantly lower than that in the control group (26.67%)(P<0.05). Conclusion The interventional therapy using Embosphere has better effect on uterine fibroid compared with the therapy using Pingyangmycin lipiodol emulsion,which is worthwhile to be brought into clinical application.
RESUMO
Two types of emulsions and suspensions were prepared using 40% Lipiodol (LIP)and Ultra-Fluid Lipiodol(UFL)with mitomycin C(MMC)by the“pumping techni- que”.The physical stabilities of each preparation were examined microscopically and macro scopically.The drug release test was made by using dissolution tester uhder rotating oar method,the concentrations of MMC released from the preparations were determined spectro- photometrically.The results showed that the emulsion was unstable,underwent phase separation easily and drug release rapidly.The stability of the emulsion was related to the proportion Lipiodol and aqueous solution(oil/water ratio),The ratio of 4:1 was ruich made stable than that of 2:1.The stability of the UFL emulsion was better than that of the LIP. The suspension was mare stable than the emulsion.The UFL suspension was much more suitable for clinical use because of not so viscons than the LIP.