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OBJECTIVE:To observe the effects of Yishen huashi granules combined with Losartan potassium tablets on renal function indexes and inflammatory factors of patients with chronic glomerulonephritis. METHODS:A total of 107 patients with chronic glomerulonephritis in our hospital during Jan. 2015-Aug. 2016 were divided into observation group(53 cases)and control group(54 cases)according to therapy plan. Besides basic therapy,control group was given Losartan potassium tablets 50 mg,po, qd;observation group was additionally given Yishen huashi granules 10 g,po,tid,on the basis of control group. Both groups were treated for consecutive 2 mouths. Clinical efficacies,renal function indexes(Scr,BUN,24 h urine protein quantification,urine red blood cell)and inflammatory factors(IL-13,CRP,TNF-α)levels were all observed in 2 groups,and the occurrence of ADR was recorded. RESULTS:Clinical total response rate of observation group(86.79%)was significantly higher than that of control group(66.67%),with statistical significance(P<0.05). Before treatment,there was no statistical significance in renal function in-dexes or inflammatory factors levels between 2 groups(P>0.05).After treatment,renal function indexes and inflammatory factors levels of 2 groups were significantly decreased;and observation group was significantly lower than control group,with statistical significance(P<0.05). No obvious ADR was found in 2 groups during treatment. CONCLUSIONS:Yishen huashi granules com-bined with Losartan potassium tablets in the treatment of chronic glomerulonephritis can improve renal function and reduce inflam-mation factor level with good safety.
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OBJECTIVE:To observe the effects of Yishen huashi granules combined with Losartan potassium tablets on renal function indexes and inflammatory factors of patients with chronic glomerulonephritis. METHODS:A total of 107 patients with chronic glomerulonephritis in our hospital during Jan. 2015-Aug. 2016 were divided into observation group(53 cases)and control group(54 cases)according to therapy plan. Besides basic therapy,control group was given Losartan potassium tablets 50 mg,po, qd;observation group was additionally given Yishen huashi granules 10 g,po,tid,on the basis of control group. Both groups were treated for consecutive 2 mouths. Clinical efficacies,renal function indexes(Scr,BUN,24 h urine protein quantification,urine red blood cell)and inflammatory factors(IL-13,CRP,TNF-α)levels were all observed in 2 groups,and the occurrence of ADR was recorded. RESULTS:Clinical total response rate of observation group(86.79%)was significantly higher than that of control group(66.67%),with statistical significance(P<0.05). Before treatment,there was no statistical significance in renal function in-dexes or inflammatory factors levels between 2 groups(P>0.05).After treatment,renal function indexes and inflammatory factors levels of 2 groups were significantly decreased;and observation group was significantly lower than control group,with statistical significance(P<0.05). No obvious ADR was found in 2 groups during treatment. CONCLUSIONS:Yishen huashi granules com-bined with Losartan potassium tablets in the treatment of chronic glomerulonephritis can improve renal function and reduce inflam-mation factor level with good safety.
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Objective To discuss the curative effects of alfacalcidol combined with losartan potassium tablets in the treatment of early diabetic nephropathy (EDN).Methods 90 EDN patients in our hospital were chosen and randomly divided into the observation group and control group (45 cases in each group).The control group was given losartan potassium tablets treatment,while the observation group was given alfacalcidol combiend with telmisartan treatment.All the two groups were treated for 3 months.Before and after treatment,the fasting blood glucose (FBG), 24h urine trace albumin quantitative (UAER),24h urine protein (24h pro),serum creatinine (SCr),25 -hydroxyl vitamin D [2 5 (OH )D ],blood calcium (Ca2+),potassium (K+),glycosylated hemoglobin (HbA 1 C )and serum inflammatory factors[C-reactive protein (CRP),tumor necrosis factor alpha (TNF-α),interleukin-6 (IL-6 )] were observed,and the correlation between 25 (OH)D and UAER,24h pro was analyzed.At the same time,the clinical curative effects and adverse reactions during treatment were evaluated.Results In the observation group,the total effective rate was 93.3%,which was significantly higher than 71.1% in the control group (χ2 =7.601,P0.05).After treatment,Scr,24h pro and UAER in the two groups were all significantly reduced compared with before treatment (P0.331).After treatment,25(OH)D in the observation group decreased significantly compared with before treatment (t=12.000,P0.436).Pearson correlation analysis showed that 25 (OH)D level was negatively correlated with 24h pro and UAER (r=0.483,0.778,all P0.151 ).Conclusion Alfacalcidol combined with losartan potassium tablets can significantly reduce the proteinuria levels of EDN patients and inflammation,which has better clinical curative effects and higher safety.
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Objective To observe the curative effect of Zhengqingfengtongning release tablets and lumbroki-nase enteric -coated capsules and losartan potassium tablets joint for the treatment of chronic nephritis proteinuria, and explore its mechanism.Methods 42 patients with chronic nephritis were randomly divided into two groups. 20 cases in the control group were given losartan potassium tablets,50mg,1 ~2 times a day.22 cases in the treatment group received Zhengqingfengtongning release tablets 120mg,2 times a day,lumbrokinase enteric -coated capsules 600 000u,3 times a day on the basis of the control group.The 24h urine protein,liver and kidney function before and after the treatment were observed.Results 20 days after treatment,24h urinary protein in the treatment group decreased 57.08%,which in the control group decreased 41.59%,the difference was statistically significant (t =2.39,P <0.05).30 days after treatment,24h urinary protein in the treatment group decreased 81.28%,which in the control group decreased 52.34%,the difference was statistically significant (t =3.65,P <0.01 ).Renal function change had no significant difference between the two groups.Conclusion Zhengqingfengtongning release tablets and lumbrokinase enteric -coated capsules combined with losartan potassium tablets in the treatment of chronic nephritis proteinuria work fast,and has good curative effect,less side effects,and is worth to recommend.
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Objective To observe the clinical effect of early diabetic nephrosis treated with Danhong injection and Losar- tan Potassium Tablets.Methods 60 patients were randomly divided into treatment group (n=30) and control group (n=30).Both grougs take orally medicine or insulin for normal blood sugar,the control group were treated with con- ventional treatment.On the basis of conventional treatment,the treatment group were treated with Danhong injection and Losartan Potassium.Results After treated for 28 days,the UAER,BUN,SCr and hemorheology were significantly improved in the treatment group than in the control group (P