Questionnaire analysis of related factors of male pattern alopecia and clinical efficacy of finasteride therapy in 320 patients / 西安交通大学学报(医学版)

Objective To study the related factors of male pattern alopecia(MPA) and efficacy of finasteride as well as to survey the related factors influencing the life quality of patients with MPA.Methods Questionnaire with dermatology life quality index(DLQI) and center for epidemiologic studies depression scale(CES-D) were adopted to assess the life quality and psychological changes of 320 outpatients with MPA.The 320 patients with MPA of Hamilton grades Ⅱ-Ⅶ took finasteride tablet of 1mg/day for over 4 months in this clinical tria1.We analyzed the related factors of MPA,tested the related indexes,and observed for changes of hair growth and adverse reactions.Results DLQI and CES-D scores of the 320 MPA patients obviously increased.Many factors including inheritance and psychological influence were correlated with MPA.The total efficacy rate after treatment for over 4 months was 80.8%.Conclusion Hair loss significantly affected the life quality of patients with MPA and brought negative effects on the patients' psychology,which can worsen hair loss.Therefore,appropriate psychotherapy and other treatments should be given to them.MPA is a kind of disease caused by multiple factors and oral administration of finasteride(1mg) is effective and safe for treating MPA.

Preliminary Study on the Mode of Inheritance of Male Pattern Alopecia (MPA) / 昆明医科大学学报

95 probands' family frees of MPA have been studied by the methods of simple segregation analysis and estimation of heritability. The result shows that MPA may be caused by different hereditary patterns. In the families with affected parents and vertical transmission. MPA may be caused by an autosomal dominant (AD) gene, making up 56.84% (AD) and 2.11% (reduced penetrance). It also shows that MPA may be due to polygenic inheritance.