Optimization of One-step Pelletization Technology of Rouganbao Granules with Orthogonal Test Methodology / 中国中医药信息杂志

Objective To optimize the process conditions of one-step pelletization of Rouganbao Granules. Methods The factors influencing the pelletization of Rouganbao Granules were investigated by L9(34)orthogonal test, with the indexes of forming rate and fluidity. Results The spraying speed had the greatest effect on one-step pelletization, followed by atomization pressure and material temperature, and wind temperature had the smallest effect. At last, the best process parameters were relative density 1.15 (60 ℃), spray speed 55 mL/min, atomization pressure 0.25 MPa, wind temperature 75 ℃, material temperature 55 ℃, and critical relative humidity was 63%. Conclusion One-step pelletization technology can improve the preparation level and product quality, which can be used for the industrial production of Rouganbao Granules.

Optimization of one-step pelletization technology of Fuke IV granules with response surface methodology / 中国中药杂志

To optimize the one-step pelletization technology of Fuke IV (FKIV) granules by response surface methodology. With the qualified rate of granules as evaluation indexes, 6 factors affecting one-step pelletization technology were investigated, significant levels of each factor were evaluated and the primal influential factors were determined by Plackett-Burman experimental design. According to the Plackett-Burman experimental design, the qualified rates of granules, moisture capacity and angle of repose as the evaluation indexes, Box-Behnken design with three levels and three factors was established for quadratic regression fitting of the models. Then the experimental results were optimized by Response Optimizer. The best process conditions were determined as follows： the extract relative density of 1.20, inlet air temperature of 88 ℃, and atomization pressure of 0.28 MPa. FKIV granules were prepared by the optimized experimental scheme. The determined qualified rate, moisture capacity and angle of response were 93.65%, 3.76% and 23.19° respectively for the granules, basically similar to the predicted values, indicating that the optimal process conditions were in line with the manufacturing requirements.

Digestibility of pelleted rations containing diverse potato flour and urea / Degradabilidade ruminal e digestibilidade in vitro de rações peletizadas contendo farinha de batata diversa e ureia

The aim of this study was to evaluate ruminal in situ degradability and in vitro digestibility of dry matter (DM) in concentrate supplements containing diverse potato flour pelletized with urea (0%, 4%, 8%, and 12% DM). Samples of feeds were incubated for 0, 2, 4, 8, 12, 24, 36, and 48h in the rumen of four fistulated sheep. Level of urea added had no significant effect (P>;0.05) on the soluble fraction (a) or potentially degradable fraction (b) of the pellets and ranged from 2.1% to 12.2% and 72.9% to 87.5%, respectively. Quadratic effects (P=0.03) of the rate of degradation of fraction "b" ranged from 4.75% h-1to 7.39% h-1; the estimated maximum value at 7.4% h-1was obtained when 5.9% urea was added to the pellet. Quadratic effects (P≤0.02) of the level of urea added to the pellets on the effective degradability (ED) of DM were evaluated after considering rumen passage rates of 2.5% h-1and 8% h-1; the maximum values of ED calculated under these rumen passage rates were estimated at 6.3% to 7.3% urea in the pellets. The in vitro digestibility of DM of the pellets showed a quadratic effect (P=0.02) at different levels of urea, with a maximum value of 96.9% achieved when 7.9% urea was added to the pellets. Our results suggest that the addition of 6-8% urea to pelleted feed promotes an increase in the in vitro digestibility and ED of DM.

Objetivou-se avaliar a degradação ruminal in situ da matéria seca (MS) e a digestibilidade in vitro de suplementos concentrados a base de farinha de batata diversa peletizada com ureia (0, 4, 8 e 12% da MS). Amostras de cada tratamento foram incubadas por 0, 2, 4, 8, 12, 24, 36 e 48 horas no rúmen de quatro ovinos fistulados. Não houve efeito (P>;0,05) do nível de inclusão de ureia sobre as frações solúvel ("a") e potencialmente degradável ("b") dos péletes, que variaram, respectivamente, de 2,1 a 12,1%, e de 72,9 a 87,5%. Foi observado efeito quadrático (P=0,03) para a taxa de degradação da fração "b", que variou de 4,75 a 7,39% h-1, sendo o valor máximo estimado em 7,4% h-1, obtido quando 5,9% de ureia foram incluídos no pélete. Foram observados efeitos quadráticos (P≤0,02) do nível de inclusão de ureia nos péletes sobre a degradabilidade efetiva (DE) da MS, considerando taxas de passagem no rúmen de 2, 5 e 8% h-1e os valores máximos de DE calculadas sob estas taxas de passagem no rúmen foram estimados com 6,3 a 7,3% de ureia nos péletes. A digestibilidade in vitro da MS dos péletes foi influenciada de forma quadrática (P=0,02) pelo nível de inclusão de ureia, com valor máximo de 96,9%, estimado quando 7,9% de ureia foram incluídos no pélete. A inclusão de 6 a 8% de ureia nos péletes promove incremento na digestibilidade in vitro e na degradabilidade efetiva da matéria seca.

Optimization of one-step pelletization technology of Tianshu Capsule by Minitab / 中草药

Objective: To optimize the one-step pelletization technology of Tianshu Capsule by Minitab software. Methods: Using the qualified rates of particles as the evaluation indexes, three significant impact factors (fluid extract-dextrin ratio, infusion frequency, and atomization pressure) of one-step pelletization technology were selected and the levels of non-significant factors were identified by the Plackett-Burman experimental design. According to single factor experiments, choosing the qualified rates of particles, moisture, and angle of repose as the evaluation indexes, three levels of the three factors were selected by Box-Behnken of central composite design to establish the multiple linear regression and binomial fitting, and the experimental data were optimized by the response optimizer. Results: The best conditions were as follows: fluid extract-dextrin of 1.57:1 put in fluid-bed and heated by fan; the temperature of the bottom material in the fluidized state was increased to 50°C, fluid extract of 2% HPMC was sprayed with frequency of 32 Hz, the frequency of fan was 30 Hz, inlet air temperature was 60°C, atomization pressure was 0.21 MPa, and feed temperature was 50°C. Conclusion: Under the Minitab optimized scheme, the average experimental results are similar to the predicted values, and Minitab software could be used in the optimization of one-step pelletization for Chinese materia medica.

Technology of Spray Pelletization for Compound Jiakang Tablets / 中药新药与临床药理

Objective To optimize the spray pelletization technology for Compound Jiakang Tablets.Methods The experiment was performed by orthogonal design,and the inspection criteria key were granule uniformity,granule size and the content of astragaloside IV,combined with the granule hygroscopic velocity.Results The optimal spray pelletization parameters were as follows:the frequency of main fan was(35.0?5)Hz,atomizational pressure was 0.1 mPa,the rate of spray was 1.2 Hz,the density of extract was 1.20 g/mL.Conclusion The granules made by this technology are uniform,burly,stable,and are beneficial for pressing into tablet.