RESUMO
Objective: To seek the flavonoids with the unique structure and to investigate the chemical ingredients in the flavonoid-rich plant- Pteridium aquilinum. Methods: The 80% EthOH extract from the degreased powder of P. aquilinum was partitioned by petroleum ether, CHCl3, EtOAc, n-butanol, and water, respectively. The EtOAc fraction was sequentially subjected to silica gel column, repeated Sephadex LH-20 column, and preparative TLC to give a new compound. The antitumor activity of the novel flavonoid was primarily evaluated by MTT. Results: Compound 1, a biflavonoid with the unique structure named as pteridium III with an unprecedented bihomoflavanonol skeleton, was isolated from P. aquilinum. Compound 1 showed the in vitro antitumor activity against lung cancer cell NCI-H46, melanoma cell A375, and glioma cell U-7MG corresponding to the IC50 values of 22.9, 106.7, and 1540.5 μmol/L, respectively. No inhibition on gastric carcinoma SGC-7901 and prostatic carcinoma PC-3 was observed in the experiment. Conclusion: A rare bihomoflavononol derivative, pteridium III, is obtained from the plant, which could enrich our knowedge on the chemical structures of flavonoids and bioactive constituents in P. aquilinum. © 2013 Tianjin Press of Chinese Herbal Medicines.
RESUMO
The new fern species Pteris herrerae A. Rojas & M. Palacios, endemic to Costa Rica, is described. It differs from P. decurrens C. Presl in basal segments reduced to 1/5-1/2 of the next segment (vs. 2/3-3/4), basal pinnae not bifurcated (vs. bifurcated), pinnae apex mucronate (vs. acuminate) and segment apex undulate (vs. dentate). It differs from Pteris consanguinea in the elliptic pinnae (vs. oblong), two segments reduced on the base (vs. lack), segments entire to undulate (vs. dentate), basal pinnae without basiscopic lobes (vs. with basiscopic lobes) and segment apex entire to undulate (vs. dentate).
Se describe Pteris herrerae A. Rojas & M. Palacios, endémica de Costa Rica. Esta es diferente de P. decurrens C. Presl por segmentos basales reducidos a 1/5-1/2 del tamaño de los siguientes (vs. 2/3-3/4), pinnas basales no bifurcadas (vs. bifurcadas), ápice de las pinnas mucronado (vs. acuminado) y ápice de los segmentos ondulado (vs. dentado). También es diferente de Pteris consanguinea Mett. ex Kuhn por pinnas deltado-lanceoladas (vs. oblongas), con un par de segmentos reducidos en la base (vs. sin ellos), pinnas basales sin lóbulos basicópicos alargados (vs. con lóbulos basiscópicos) y segmentos enteros a ondulados (vs. dentados).