Climate change: its impact on mental health and women and children's well-being

Amid every crisis, women and children are considered the most vulnerable segments of the population. As such factions potentially get affected in every natural calamity. According to WHO, it has been evaluated that climate change will unravel all the achievements made in global public health over the past 50 years, sending 100 million people into poverty and killing 250,000 others annually. Although these figures are daunting, the ability to act robustly and effectively is indeed not out of capacity. Hence, it is pertinent to reforming and re-orienting health systems and bring robust strategies into action to mitigate the challenges posed by climate challenges in the present century. The world cannot afford the continuous agony of millions of masses and witnessing innocent people falling prey to several diseases and conditions that can lead them to face lifelong implications.

The effects of minocycline on neuroinflammation in rats with post-traumatic stress disorder / 神经解剖学杂志

Objective:To investigate the effect of minocycline on neuroinflammation of rats with post-traumatic stress disorder(PTSD).Methods:The rat model of PTSD was prepared by a single prolonged stress(SPS)method,and the rats were treated with minocycline(PTSD+Mino group)or normal saline(PTSD group)by gavage.The behavioral changes of rats were detected by light-dark box test.The expression of ionized calcium-binding adapter molecule 1(Iba-1)in hippocampus was detected by immunohistochemical staining.The contents of IL-1β and TNF-α in hippocampus were detected by ELISA,and the expression levels of IL-1β and TNF-α mRNA in hippocampus were detected by real-time RT-PCR(qRT-PCR).Results:After 3 days of SPS stimulation,the anxiety-like behavior of rats was obvious,the expression of Iba-1 in hippocampus was increased,and the contents of IL-1β and TNF-α in hippocampus were in-creased.Minocycline treatment significantly reduced anxiety-like behavior and decreased the expression of Iba-1 in the hippocampus of PTSD rats.Meanwhile,minocycline treatment also decreased the levels of IL-1β and TNF-α mRNA and protein in the hippocampus.Conclusion:Minocycline can improve the anxiety-like behavior of PTSD rats by inhibiting the activation of microglia.

Experience with Chikujountanto (Untanto) for Trauma- and Stressor- Related Disorders / 日本東洋医学雑誌

I report five cases in which chikujountanto and untanto were effective for trauma and stressor-related disorders. Post-traumatic stress disorder (PTSD) and acute stress disorder (ASD) are both psychiatric disorders that occur as a reaction to severe stress, and are distinguished by the duration of the disorder. Chikujountanto is indicated for those who have cough and insomnia after late yang stage pattern in case of cold, and for chronic diseases such as depression and sleep disorders, and is applied to various psychiatric disorders. In this paper, I cite the grounds for applying chikujountanto to PTSD from the classics, examine the similarities and differences with other Kampo medicines reported to be used for PTSD from the characteristics of the constituent crude drug centered on Huang lian. I also infer the relationship between the therapeutic mechanism of Kampo and neuroinflammation. Regardless of the severity of the trauma, rapid administration of this drug is expected to hasten the healing process.

The interaction between polygenic risk score and trauma affects the likelihood of post-traumatic stress disorder in female victims of sexual assault

Objective: Post-traumatic stress disorder (PTSD) is triggered by traumatic events, but genetic vulnerability and a history of childhood trauma may also increase the risk of PTSD onset. Thus, we investigated the interaction between genetic susceptibility according to polygenic risk score (PRS), and traumatic events. Methods: We evaluated 68 women with PTSD who had been sexually assaulted and 63 healthy controls with no history of sexual assault. DNA was genotyped using the Infinium Global Screening Array (Illumina, San Diego, CA, USA), and PRS analysis was performed using PRSice. Logistic regression models were also used to determine the interaction between childhood trauma, traumatic life events, and PRS and how they contribute to PTSD risk. Results: We found a significant association between PRS, childhood trauma (p = 0.03; OR = 1.241), and PTSD. There was also an interaction between PRS, traumatic life events, and childhood trauma, particularly physical and emotional neglect (p = 0.028; OR = 1.010). When examining neglect separately, we found a modest association between emotional neglect and PTSD (p = 0.014; OR = 1.086). Conclusion: Our findings highlight the importance of considering genetic vulnerability and traumatic experiences in understanding the etiology of PTSD.

Psychological distress and its predictors among hospital admitted COVID-19 patients in India

Background: Limited evidence is available on the psychological distress among patients hospitalized with COVID -19. We assessed the incidence of psychological distress, posttraumatic symptoms and substance use among patients hospitalized with COVID-19; and perceived stress, coping, and social support experienced by distressed and non-distressed patients and the predictors of psychological distress. Methods: Ours was a hospital-based cross-sectional study, conducted in a Union Territory of India. Patients were assessed (August – September, 2020) at the time of admission (within two days) with standardized instruments (N=250). Results: More than 19 percent of respondents had experienced significant psychological distress (probable cases) and nearly 9% reported post-traumatic stress symptoms. The cases and non-cases differ in terms of active coping (5.51±0.87 versus 5.06±1.06; t=3.10, p<0.01), emotional support (5.21±0.87 versus 4.86±0.79; t=2.57, p<0.01), behavioural disengagement (5.18±0.92 versus 4.55±1.15; t=3.56, p<0.001), venting (5.42±0.96 versus 4.80±1.24; t=3.30, p<0.01), acceptance (5.75±1.24 versus 5.29±1.50; t=2.23, p<0.05), religion (5.43±1.41 versus 6.06±1.46; t=-2.76, p<0.01) and self-blame (5.65±1.00 versus 4.82±1.39; t=3.95, p<0.001). Symptoms of post-traumatic stress (OR: 2.058; 95% CI: 1.49-2.84) was the only significant predictor of the psychological distress. Conclusions: Nearly one in five hospitalized patients with COVID-19 experience psychological distress. Screening and treatment for trauma and psychological distress should be an integral component of care for patients with COVID-19.

Traumatic Experiences and Psychopathological symptoms in Prison Population and General Population

Traumatic events are stressful episodes that exceed an individual's coping resources and have been related to physical and mental health problems, particularly posttraumatic stress disorder. This study aims to compare the prison population and the general population in terms of trauma and psychopathological symptoms derived from exposure to traumatic events in the context of Ecuador. It is a descriptive-comparative and cross-sectional study. The study sample consisted of 99 incarcerated individuals and 84 persons from the general population of Ambato-Ecuador. The results indicate that persons from the prison population have experienced multiple traumas and re-victimization to a greater extent and present a higher percentage of PTSD and psychopathological symptoms than the general population. In that sense, it is a population that requires more significant intervention to reduce symptoms and prevent violent behavior.

Los eventos traumáticos son hechos estresantes que exceden los recursos de afrontamiento de un individuo y han sido relacionados con problemas de salud física y mental, particularmente con el trastorno de estrés postraumàtico. El objetivo de este estudio es comparar las experiencias traumáticas y los síntomas psicopatológicos entre la población penitenciaria y la población general. Es un estudio descriptivo-comparativo de corte transversal. La muestra del estudio estuvo conformada por 99 individuos encarcelados y 84 individuos de la población general de Ambato (Ecuador). Los resultados indican que los participantes de la población penitenciaria han experimentado en mayor medida múltiples traumas y revictimización; presentan un mayor número de síntomas psicopatológicos y un porcentaje más elevado de TEPT que la población general. Las diferencias que se presentan entre la población penitenciaria y la población general pueden deberse a que las personas encarceladas son más vulnerables a estar expuestas a eventos potencialmente traumáticos por su propia situación social. La población penitenciaria requiere una mayor intervención para reducir los síntomas psicopatológicos provocados por el trauma.

Physiological and Biological Testing and Assessment of Post-Traumatic Stress Disorder / Physiological and Biological Testing and Assessment of Post-Traumatic Stress Disorder / Testes fisiológicos e biológicos e avaliação do Transtorno de Estresse Pós-Traumático

This review essay investigates the biological and physi- ological consequences of PTSD to deepen its academic understanding, alongside an analysis of psychobiologi- cal testing and assessment procedures. Psychological responses to traumatic events can be acute stress reactions or stress disorders. One among them is post-traumatic stress disorder (PTSD). When people experience a trau- matic event, such as death, terror, or physical injury, they tend to demonstrate fear, helplessness, or hopelessness. Patients displaying other symptoms like re-experiencing the trauma, avoidance, or hyper-arousal also indicate PTSD. Experiencing extended PTSD may cause significant health problems, whether biological, such as the dysfunction of stress-responsive neurobiological sys- tems, or physiological, such as hypertension and heart disease. Previous studies of trauma survivors reported a strong link between physical and mental health. The cumulative literature in psychology shows that traumatic exposure can cause disturbing effects in the short and long term. This review will contribute to developing an understanding of the biological markers of PTSD. This paper specifically deals with biological and physiological testing and assessment of PTSD. It includes widely utilized biological assessments and summarizes a general multi-model assessment to identify PTSD symptoms.

Las respuestas psicológicas a acontecimientos traumáticos pueden dar lugar a estrés agudo, trastornos de estrés o trastornos de estrés postraumático (TEPT). Cuando las personas experimentan un evento traumático, como la muerte de un ser querido, terror o daño físico, tienden a mostrar miedo, impotencia o desesperanza. Mostrar otros síntomas como volver a vivir aquellas experiencias, evasión o hiperexcitación indica TEPT. Sufrir el TEPT a largo plazo puede causar problemas de salud importantes, ya sean biológicos, como la disfunción de los sistemas neurobiológicos sensibles al estrés; o fisiológicos, como la hipertensión y enfermedades cardíacas. Sin embargo, la literatura psicológica deja poco o ningún espacio para tales consecuencias sobre la salud. Para proporcionar información sobre este tema, la presente revisión tiene como objetivo investigar las consecuencias biológicas y fisiológicas del TEPT, y las pruebas y evaluaciones psicobiológicas relacionadas. Esta revisión de la literatura puede contribuir al desarrollo de marcadores biológicos de TEPT.

As respostas psicológicas a eventos traumáticos po- dem levar a estresse agudo, transtornos de estresse ou transtorno de estresse pós-traumático (TEPT). Quando as pessoas vivenciam um evento traumático, como a morte de um ente querido, terror ou danos físicos, elas tendem a demonstrar medo, desamparo ou desesperança. Mostrar outros sintomas, como reviver essas experiências, evitação ou hiperexcitação, indica TEPT. Sofrer de TEPT de longa duração pode causar problemas de saúde significativos, sejam eles biológicos, como disfunção de sistemas neurobiológicos sensíveis ao estresse; ou fisiológicos, como hipertensão e doenças cardíacas. No entanto, a literatura psicológica deixa pouco ou nenhum espaço para a discussão de tais consequências para a saúde. Para fornecer informações sobre esse tópico, a presente revisão tem como objetivo investigar as consequências biológicas e fisiológicas do TEPT, assim como testes e avaliações psicobiológicas relacionados. Esta revisão de literatura pode contribuir para

"Congelei com medo de me contaminar": tratando um caso de TEPT crônico com imobilidade tônica em uma fisioterapeuta da linha de frente na pandemia de COVID-19 / "I froze for fear of contaminating myself": treating a case of chronic PTSD with tonic immobility in a physiotherapist frontline during COVID-19 pandemic

RESUMO Objetivo: Neste estudo relatamos o caso de uma profissional de saúde com vivência de imobilidade tônica (IT) e posterior desenvolvimento de transtorno de estresse pós-traumático (TEPT) crônico em decorrência de trauma laboral por conta da COVID-19 que recebeu tratamento remoto com terapia cognitivo-comportamental focada no trauma (TCC-FT). Métodos: Relato de caso de uma paciente acompanhada por seis meses após o recebimento de TCC-FT remota. Resultados: Paciente do sexo feminino, de 36 anos, fisioterapeuta, que desenvolveu TEPT crônico e experienciou IT por medo da contaminação por coronavírus. As escalas psicométricas demonstraram que a TCC-FT reduziu consideravelmente os sintomas de TEPT e depressão e aumentou o apoio social e a resiliência. De acordo com o relato, o tratamento melhorou a concentração e a motivação, e reduziu o sentimento de culpa, a irritabilidade, a insegurança e o desconforto em lidar com outras pessoas. Conclusão: Este artigo demonstra que traumas decorrentes da COVID-19 podem ser capazes de desencadear IT e exemplifica um favorável desempenho da TCC-FT na melhoria global da saúde mental dos pacientes com TEPT crônico com vivência de IT.

ABSTRACT Objective: In this study, we report the case of a health professional with experience of tonic immobility (TI) and subsequent development of post-traumatic stress disorder (PTSD) as a result of occupational trauma due to COVID-19 who received remote treatment with Trauma-Focused Cognitive Behavioral Therapy (TF-CBT). Methods: A case report of a patient followed for six months after receiving remote TF-CBT. Results: A 36-year-old female patient, the physiotherapist who developed chronic PTSD and experienced TI for fear of coronavirus contamination. Psychometric scales demonstrated that TF-CBT considerably reduced PTSD and depression symptoms and increased social support and resilience. According to the report, the treatment improved concentration and motivation, and reduced feelings of guilt, irritability, insecurity, and discomfort in dealing with other people. Conclusion: This article demonstrates that trauma resulting from COVID-19 can trigger TI and exemplifies a favorable performance of TF-CBT in the global improvement of the mental health of patients with chronic PTSD who experience TI.

Silêncio na redação ­ a saúde mental de jornalistas na abordagem da comunicação de riscos / Silence in the newsroom ­ journalist's mental health from the risk communication approach / Silencio en la redacción ­ la salud mental de los periodistas en el abordaje de la comunicación de riesgo

Desde a década de 1990, o psiquiatra sul-africano Anthony Feinstein tem abordado o tema da saúde mental de jornalistas na cobertura de tragédias humanitárias, com foco no Transtorno do Estresse Pós-traumático (TEPT) e em moral injury (lesão moral), definido como uma ferida na alma. Em 2020, primeiro ano da pandemia da covid-19, o artigo "The covid reporters are not okay. Extremely not okay", da jovem jornalista Olivia Messer, trabalhando on-line, chamou a atenção não apenas para o tema da saúde mental dos repórteres, como também para a invisibilidade do assunto. Este artigo objetiva investigar como a comunicação de riscos pode contribuir para descortinar e enfrentar os riscos à saúde mental de jornalistas no Brasil, especialmente no contexto das redações híbridas e da plataformização do jornalismo, um dos campos que compõem o referencial teórico em seu cruzamento com a comunicação de riscos e a psiquiatra. A metodologia contempla a pesquisa bibliográfica nessas três áreas, a plataformização do jornalismo, a comunicação de riscos e a psiquiatria, a partir da conexão entre elas, e da análise de conteúdo, de base quantitativa, da cobertura do assunto pelos jornais Folha de S.Paulo e O Globo. Os resultados apontam a urgência da retirada do tema da invisibilidade midiática e social e confirmam a potencialidade da comunicação de riscos para o seu enfrentamento.

Since the 1990s, South African psychiatrist Anthony Feinstein has addressed the issue of the mental health of journalists covering humanitarian tragedies, focusing on Post-traumatic Stress Disorder (PTSD) and moral injury, defined as a wound in the soul. In 2020, the first year of the covid-19 pandemic, the article "The covid reporters are not okay. Extremely not okay", by young journalist Olivia Messer, working online drew attention not only to the issue of reporters' mental health, but also to the invisibility of the issue. This article aims to investigate how risk communication can contribute to uncover and address the risks to the mental health of journalists in Brazil, especially in the context of hybrid newsrooms and the plat-formization of journalism, one of the fields that make up the theoretical framework in its intersection with risk communication and psychiatry. The methodology includes bibliographic research in these three areas, platformization of journalism, risk communication and psychiatry, from the connection between them, and content analysis, of quantitative basis, of the coverage of the subject by Folha de S.Paulo and O Globo newspapers. The results point to the urgency of removing this issue of media and social invisibility and recognising the potential of risk communication to face it.

Desde la década de 1990, el psiquiatra sudafricano Anthony Feinstein ha abordado la cuestión de la salud mental de los periodistas que cubren tragedias humanitarias, centrándose en el Trastorno de Estrés Pos-traumático (TEPT) y el moral injury (el daño moral), definidos como una herida en el alma. En 2020, el primer año de la pandemia de covid-19, el artículo "The covid reporters are not okay. Extremely not okay", de la joven periodista Olivia Messer, que trabaja en línea, llamó la atención no sólo sobre la cuestión de la salud mental de los periodistas, sino también sobre la invisibilidad del tema. Este artículo pretende investigar cómo la comunicación de riesgo puede contribuir a descubrir y abordar los riesgos para la salud mental de los periodistas en Brasil, especialmente en el contexto de las redacciones híbridas y la plata-formización del periodismo, uno de los campos que conforman el marco teórico en su intersección con la comunicación de riesgo y la psiquiatría. La metodología contempla la investigación bibliográfica en estas tres áreas, plataformización del periodismo, comunicación de riesgo y la psiquiatría, a partir de la conexión entre ellas, y el análisis de contenido, de base cuantitativa, de la cobertura del tema por los periódicos Folha de S.Paulo y O Globo. Los resultados apuntan a la urgencia de sacar el tema de la invisibilidad mediática y social y confirman la potencialidad de la comunicación de riesgos para su confrontación

EXPLORATION OF OVERWHELMING CRISIS OF PTSD THROUGH TRAUMA NARRATIVE OF ROXANE GAY'S AN UNTAMED STATE

The 21st century is a tech world undergoing surplus ?uctuations, familiarizing the new era, literature re?ects real life changes, challenges, problems and chaos. Though complications like famine, pandemic, accidents, failures, physical abuses, wars etc., physically gets alright, mind and the repressed memory ?nds a way out and the individual faces the psychological tremor, recollecting and re-living the traumatic moment that causes anxiety and waves of panic. The main objective of this paper is to explore the overwhelming emotional crisis of an individual affected from PTSD and the ruptured life after the traumatic incident through the interesting narrative of Roxane Gay's An Untamed State. The plot revolves around the character Mireille, a lawyer abducted for a huge ransom undergoes severe physical and psychological torture. The real horror of her life and unspeakable trauma explodes when she was released after 13 days. Her devastating bitter experience starts to shake her life stripping her identity and affecting her remarkable life altogether. The novel and the psychological study credibly portray and put forth the intricacies of rape trauma syndrome stricken life and surviving its ?erce pangs.

Mindfulness-Based Cognitive Therapy (MBCT) and Mindfulness-Based Stress Reduction (MBSR) in the treatment of Post-Traumatic Stress Disorder (PTSD): A literature review / Terapia Cognitiva Basada en Mindfulness y Reducción del Estrés Basada en Mindfulness en el tratamiento del Trastorno de Estrés Postraumático (TEPT): Una revisión de literatura

Abstract Background Previous reviews have concluded that whilst mindfulness-based interventions reduce PTSD symptoms through fear extinction and cognitive restructuring, further research is needed. Objective The aim of this report is to systematically review existing literature about the association between standardized mindfulness-based interventions and PTSD with the aim of identifying implications for practice and recommendations for future research. Method The CINAHL Complete, PsycINFO, Medline, and PsycArticles databases were searched, looking for full-text articles from 2018 up to march 2022. Results There was a significant improvement in PTSD symptoms in MBCT participants, even if some experienced a high increase at baseline. MBSR participants with moderate to severe trauma symptoms showed a greater reduction in symptoms whereas mild trauma symptoms at baseline showed slightly higher symptomatology at the end of treatment. Discussion and conclusion From the results, MBCT, MBSR, and their variations seem to tackle different domains of the diagnosis. Whilst MBSR is associated with improvements in terms of attentional difficulties, MBCT facilitates the connection between dysfunctional cognitive concepts and avoidant behaviours that maintain the symptomatology. Nevertheless, the active components of MBCT or MBSR that have an impact on symptom reduction are undetermined. Future studies will be enhanced by monitoring the change in underlying mechanisms attached to the practice of mindfulness through outcome measurements, among other considerations.

Resumen Antecedentes Las revisiones anteriores han concluido que las intervenciones basadas en la atención plena reducen los síntomas del TEPT a través de la extinción del miedo y la reestructuración cognitiva, aunque se requiere mayor evidencia. Objetivo Revisar sistemáticamente la literatura existente sobre la asociación entre las intervenciones estandarizadas basadas en mindfulness y el TEPT con el objetivo de identificar implicaciones para la práctica y recomendaciones para futuras investigaciones. Método Se realizaron búsquedas en las bases de datos CINAHL Complete, PsycINFO, Medline y PsycArticles de textos completos desde 2018 hasta marzo de 2022. Resultados Hubo una mejora significativa en los síntomas de TEPT en los participantes de MBCT, incluso si algunos experimentaron un gran aumento al inicio. Los participantes de MBSR con síntomas de trauma moderado a severo mostraron una mayor reducción de los síntomas, mientras que los síntomas de trauma leve al inicio mostraron una sintomatología ligeramente más alta al final del tratamiento. Discusión y conclusión A partir de los resultados, MBCT, MBSR y sus variaciones parecen abordar diferentes dominios del diagnóstico. Mientras que MBSR se asocia con mejoras en términos de dificultades atencionales, MBCT facilita la conexión entre conceptos cognitivos disfuncionales y conductas de evitación que mantienen la sintomatología. Sin embargo, los componentes activos de MBCT o MBSR que tienen un impacto en la reducción de los síntomas son indeterminados. Los estudios futuros se mejorarán al monitorear el cambio en los mecanismos subyacentes asociados a la práctica de la atención plena a través de mediciones de resultados, entre otras consideraciones.

Abnormal neuronal activation associated with fear memory extinction in the hippocampus of a PTSD mouse model / 神经解剖学杂志

Objective:To analyze the differences in neuronal activation during fear memory extinction in various sub-regions of the hippocampus in post-traumatic stress disorder(PTSD)mice.Methods:Two immediate early gene-pro-tein labeling strategies were employed to label neurons associated with fear extinction in PTSD mice.In the first group,Arc protein in hippocampal neurons was labeled and observed through immunofluorescence staining in wild-type mice.In the second group,Fos-CreERT2;Ai9 transgenic mice were injected with tamoxifen 23 hours prior to inducing fear memory extinction,and the relevant neurons were labeled with fluorescent proteins for observation.The number of labeled hippocampal neurons and the dendritic branch structure were analyzed to compare the activation levels of hipp-ocampal neurons and the plasticity of neuronal dendrites.Results:The two groups of Arc and Fos positive neurons were mainly distributed in the dorsal hippocampus,in which Arc protein chromogenic was enriched in CA3 and DG subre-gions,while CA1 and CA2 subregions were scattered,while Fos-positive neurons were enriched in the DG subregion of hippocampus and scattered in CA1,CA2 and CA3 subregions.Compared to the control group,there was no significant difference in the number of neurons expressing Arc protein in each subregion of the hippocampus in the PTSD group.The number of Fos-positive neurons in CA1,CA3 and DG subregions in the hippocampus of the PTSD group was signifi-cantly increased(P＜0.01).The dendritic branches of neurons in the hippocampal region were observed and analyzed in Fos-CreERT2;Ai9 mice from both groups,but no significant changes were found.Conclusion:Abnormal activation of neurons occurs in different subregions of the hippocampus during fear extinction in PTSD mice,although there are no significant plasticity changes in the dendritic branches of the activated neurons.

The effects of exercise on the expression of ferroptosis-related proteins in mice with post-traumatic stress disorder / 神经解剖学杂志

Objective:The study aimed to investigate the effects of exercise on the expression of ferroptosis-related proteins and the associated mechanisms in a post-traumatic stress disorder(PTSD)model induced by transient foot shock.Methods:Thirty-five male C57BL/6J mice(8 weeks old)were randomly divided into three groups:Control group,PTSD group,and Exe+PTSD group.PTSD model mice were established by foot-shock and PTSD behaviors were assessed using a fear conditioning box.Iron distribution areas were detected by Fe3+staining.Western Blot analysis were performed to determine the expression level of ferroptosis-related proteins in the mice.Results:Compared to the control group,the freezing time and Fe3+distribution areas in the cortex and hippocampus were significantly increased in the mice with PTSD(P＜0.05).The levels of ferroportin1(FPN1),glutathione peroxidase 4(GPX4),and brain-derived neurotrophic factor(BDNF)proteins were significantly decreased(P＜0.05),while the expression of high mobility group box 1(HMGB1)protein was significantly elevated(P＜0.05).Exercise significantly reduced freezing time and Fe3+accumulation in the cortex and hippocampus(P＜0.05),and it also up-regulated the expression of FPN1,GPX4,and BDNF proteins(P＜0.05),while down-regulating HMGB1 expression compared to the PTSD group(P＜0.05).Conclusion:This study demonstrates that PTSD induces the ferroptosis-related pathway in mice,and exercise can inhibit iron accumulation and reverse the expression of ferroptosis-related proteins induced by PTSD,there-by alleviating PTSD-like behavior in mice.

The effects of melatonin therapy on hypothalamic-pituitary-adrenal axis in rats with posttraumatic stress disorder / 神经解剖学杂志

Objective:To investigate the effects of melatonin(MLT)on hypothalamic-pituitary-adrenal(HPA)axis in posttraumatic stress disorder(PTSD)rats induced by foot shocks.Methods:The rat model of PTSD was prepared by plantar electroshock,and MLT was given by intraperitoneal injection.The behavioral changes of rats were detected by rejection reaction test,the mRNA expression of corticotropin-releasing hormone(CRH)in hypothalamus was detected by real time RT-PCR,and the contents of adrenocorticotropin hormone(ACTH),epinephrine(EPI)and glucocorticoid(GC)in serum were detected by enzyme-linked immunosorbent assay(ELISA).Results:In the PTSD group,the rejection reaction was obvious,the expression of CRH mRNA in hypothalamus was increased(P＜0.05),the serum ACTH and EPI were increased(P＜0.05),but the GC level was decreased(P＜0.05).After MLT treatment,the rejection reaction of PTSD rats was significantly alleviated,CRH mRNA expression in hypothalamus was decreased(P＜0.05),serum ACTH and EPI levels were decreased(P＜0.05),and GC levels were increased(P＜0.05).Conclusion:MLT treatment can relieve the symptoms of PTSD and restore the neuroendocrine balance of HPA axis in rats.

Environmental Factors of Commuting Accidents among Firefighter Drivers in Peninsular Malaysia: A Case study

Introduction@#Commuting accidents (CAs) caused significant detrimental impacts on the Fire and Rescue Department of Malaysia (FRDM). Therefore, this study aims to identify factors of CA by mainly focusing on environmental factors@*Methodology@#The qualitative data was obtained from FRDM accident investigation reports from five states (Kedah, Selangor, Kuala Lumpur, Negeri Sembilan and Johor) between 2017-2021. The data were analysed using content analysis.@*Results@#Four environmental factors that contribute to CA were identified. The factors were environmental conditions (rainfall, strong wind, light glare, and insufficient lighting), time (twilight and night time), road physical conditions (hilly road, curvy, steep, and narrow road, weak manhole cover, soft ground, wet and slippery road), and road environment (traffic congestion and sudden animal crossing)@*Conclusion@#These findings provide environment-related hazards input for risk assessment and management of CA in FRDM, as well as valuable information for future research. Therefore, it has the potential to improve road safety for firefighters, the general public, and animals

Psychological impact of the COVID-19 pandemic on anaesthetists in an academic institution in South Africa

Background: Anaesthesiology is considered to be a medical speciality that can result in high levels of stress. The COVID-19 pandemic required anaesthetists to rapidly adopt additional challenging roles. This study describes the psychological impact of the pandemic on anaesthetists and identified and compared factors associated with depression, anxiety, stress, and post-traumatic stress disorder (PTSD). Methods: A cross-sectional study design was used. An anonymous questionnaire was used to collect data utilising convenience sampling and results were reported using descriptive statistics and logistic regression analysis. The order of importance for the sources of stress and organisational support was determined by calculating the median rank. Results: The majority of the participants were between ages 31­40 (62.6%), male (59.8%), registrars (47.6%), had no comorbidities (73.8%), and had no known mental illness (79.9%). Having a previous diagnosis of a mental health illness was linked with greater levels of depression (OR [95% CI] = 4.50 [2.02­10.24], p < 0.001), anxiety(OR [95% CI] = 3.9 [1.7­9.0], p = 0.001), stress (OR [95% CI] = 3.8 [1.6­9.2], p = 0.002), and PTSD (OR [95% CI] = 5.4 [2.2­13.5], p < 0.001). Sources of stress identified included: insecure access to appropriate personal protective equipment, being exposed to COVID-19 at work, and taking the infection home to family. Conclusion: Participants with a history of mental illness were predisposed to developing negative psychological symptoms as a result of the pandemic. The main source of stress identified was insecure access to appropriate personal protective equipment.

The COVID-19 pandemic and its impact on mental health of healthcare workers / A pandemia de COVID-19 e seu impacto na saúde mental dos profissionais de saúde

ABSTRACT The COVID-19 pandemic has imposed a health crisis around the world. Health professionals are frequently exposed to stressors that put them at high risk for the development or progression of disabling mental disorders, including posttraumatic stress disorder (PTSD). To understand how pandemic stressors have affected the mental health of healthcare workers, our group conducted a longitudinal and nationwide survey. We investigated the occurrence of traumatic events related to the COVID-19 pandemic and the association between exposure to these events and PTSD symptomatology. Importantly, we also investigated factors that might increase or decrease the risk for PTSD. Depression symptoms were also investigated. The results of the first wave of the project were published in a series of three articles, each focused on different risk or protective factors. The results showed that female sex, young age, a lack of adequate personal protective equipment, social isolation and a previous history of mental illness were consistent predictors of PTSD symptoms. Healthcare workers who reported high levels of peritraumatic tonic immobility, a defensive response that is involuntary, reflexive, and evoked by an intense and inescapable threat, also exhibited an increase in the probability of being diagnosed with PTSD. On the other hand, professional recognition had a negative relationship with PTSD and depression symptoms, emerging as a significant protective factor for psychological health. The identification of protective and risk factors in these situations is crucial to guide the adoption of long-term measures in work environments that will enhance the psychological health of these professionals.

RESUMO A pandemia de COVID-19 impôs uma crise de saúde no mundo. Profissionais de saúde foram frequentemente expostos a estressores que os colocam em alto risco para o desenvolvimento ou progressão de transtornos mentais incapacitantes, incluindo o transtorno de estresse pós-traumático (TEPT). Para entender como esses estressores afetaram a saúde mental desses profissionais, nosso grupo realizou um estudo longitudinal nacional. Investigamos a ocorrência de eventos traumáticos especificamente relacionados à pandemia e a associação entre a exposição a esses eventos traumáticos e a sintomatologia do TEPT. É importante ressaltar que também investigamos fatores que podem aumentar ou diminuir o risco de TEPT. Sintomas de depressão também foram investigados. Os resultados da primeira onda do projeto foram publicados em uma série de três artigos, cada um focado em diferentes fatores de risco ou proteção. Os resultados mostraram que sexo feminino, idade jovem, falta de equipamento de proteção individual adequado, isolamento social e história prévia de doença mental foram preditores consistentes de sintomas de TEPT. Os profissionais de saúde que relataram altos níveis de imobilidade tônica, uma resposta peritraumática involuntária e reflexa evocada em situações de ameaça intensa e inescapável, exibiram aumento na probabilidade de um provável diagnóstico de TEPT. Por outro lado, reconhecimento profissional teve relação negativa com sintomas de TEPT e depressão, emergindo como importante fator de proteção para a saúde mental. Identificar fatores protetores ou de risco nessas situações é fundamental para orientar a adoção de medidas de longo prazo nos ambientes de trabalho que melhorem a saúde mental desses profissionais.

As raízes do trauma: uma revisão sobre a história do psicotraumatismo / The roots of trauma: a review of the history of psychotrauma

Resumo A percepção do papel do trauma psicológico na origem de problemas psiquiátricos aumentou e diminuiu ao longo da história da psiquiatria. Com a concepção do transtorno de estresse pós-traumático (TEPT), entretanto, as sociedades ocidentais presenciaram uma profunda expansão do discurso do traumatismo na interpretação de experiências humanas devastadoras, como catástrofes, genocídios, desastres e epidemias. A partir de revisão bibliográfica integrativa, este artigo analisa alguns dos determinantes históricos e epistemológicos que fundamentam o surgimento da memória traumática e o estabelecimento do trauma como campo semântico que orienta respostas clínicas e estratégias políticas no campo das ciências humanas e da saúde.

Abstract Perceptions of the importance of the role of psychological trauma in the origins of psychiatric problems have oscillated throughout the history of psychiatry. However, since the conception of post-traumatic stress disorder (PTSD), western societies have witnessed a marked expansion of the discourse of trauma in the interpretation of devastating human experiences like catastrophes, genocides, disasters, and epidemics. Through an integrative literature review, this article analyzes some of the historical and epistemological determinants behind the emergence of traumatic memory and the establishment of trauma as a semantic field that orients clinical responses and political strategies in the field of the humanities and the health sciences.

O protocolo ASSYST-RG reduz estresse em profissionais da saúde na pandemia / The ASSYST protocol reduces stress in health care workers in the pandemic

Introdução: o aparecimento de casos de COVID-19 acarretou o surgimento de estresse agudo na população em geral, em especial nos profissionais da saúde e, dentre eles, nos de saúde mental, que passaram a ter alta demanda para atendimento a pessoas acometidas de transtornos relacionados a trauma e a estressores, em decorrência de isolamento social, internação hospitalar, óbitos, piora da situação financeira com a perda de emprego, dentre outros. Objetivo: este trabalho, realizado com o Protocolo para Estabilização da Síndrome do Estresse Agudo remoto, em formato grupal, tem por Objetivo fornecer os primeiros cuidados psicológicos, visando a reduzir as perturbações e melhorar o funcionamento adaptativo, evitando a evolução para quadros psicológicos mais disfuncionais, como o transtorno de estresse pós-traumático (TEPT). Metodologia: foram selecionados 23 participantes (psicólogos) e todos responderam às escalas de avaliação psicométrica (HADS e PCL-5) antes e depois de duas (2) sessões de terapia on-line (videoconferência), com aplicação do referido Protocolo. Resultados: o modelo de regressão mostra redução média no escore de ansiedade de -2,3 (ep 0,9), com p-valor = 0,0010 (significante); no escore de depressão, média de 1,13 (p=0,125); e no escore de TEPT, redução média de ­9,5 (3,3), com p-valor=0,006. Discussão: os Resultados estatísticos revelaram aproximação com os Resultados da pesquisa realizada por Becker et al. Assim como esses autores, nenhum efeito adverso foi relatado pelos participantes durante a intervenção, confirmando a eficácia, a viabilidade e a segurança do Assyst-RG. Conclusão: os Resultados evidenciam que o Assyst-RG foi eficaz na diminuição da ansiedade, da depressão e do TEPT.

Introduction: the emergence of cases of COVID-19 led to the emergence of acute stress in the general population, especially in health professionals and, among them, in mental health, who began to have a high demand for care for people suffering from disorders. related to trauma and stressors as a result of: social isolation, hospitalization, deaths, worsening of the financial situation with loss of job, among others. Objective: this work with the Protocol for the Stabilization of Acute Remote Stress Syndrome in Group Format aims to provide the first psychological care to reduce disturbances and improve adaptive functioning, avoiding the evolution to more dysfunctional psychological conditions such as Post Stress Disorder -Traumatic (PTSD). Methodology: twenty-three (23) participants (psychologists) were selected and all responded to psychometric assessment scales (HADS and PCL-5) before and after 2 (two) online therapy sessions (videoconference) with application of the protocol. Results: the regression model shows a mean reduction in the anxiety score of -2.3 (ep 0.9), with p-value = 0.0010; significant; in the depression score, mean of 1.13 (p=0.125); and in the PTSD score, a mean reduction of ­9.5 (3.3), with p-value=0.006. Discussion: the statistical Results revealed an approximation with the Results of the research carried out by Becker et al (2021). According to these authors, no adverse effects were reported by the participants during the intervention, confirming the efficacy, feasibility and safety of ASSYST-RG. Conclusion: the Results show that ASSYST-RG was effective in reducing anxiety, depression and PTSD.

Mini International Neuropsychiatry Interview Kid or Child Posttraumatic Stress Disorder Symptom Scale 5I for Posttraumatic Stress Disorder among Adolescent Girls Infected with COVID-19

Background: Posttraumatic stress disorder (PTSD) is a mental disorder that may develop after exposure to exceptionally life threatening or horrifying events. People suffering from PTSD are vulnerable for both physical and mental health. Objectives: To find out sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and to plot receiver operating characteristic curve taking Mini International Neuropsychiatry Interview-Kid (MINIKID) as the gold standard and Child PTSD Symptom Scale 5I (CPSS-5I) as the newer diagnostic tool for diagnosing PTSD. Materials and Methods: The cross?sectional study was carried out for a period of 6 months from January 2021 to June 2021 at R. L. Jalappa Hospital and Research Center, Kolar, Karnataka through telephonic interviews. All the data entered in Microsoft office Excel sheet, analyzed using the SPSSv22 (IBM Corp). Results: Sensitivity of the CPSS?5I was 56% and specificity was 96% compared with MINIKID. 83% and 85%, respectively, was PPV and NPV of the CPSS?5I compared with MINIKID. Area under the curve is 83.9% with P < 0.001 (72.5–95.2) indicating CPSS?5I is 84% sensitive proving to be a very good diagnostic tool for diagnosing PTSD. Furthermore, scores of 9.5 or 10.5 from CPSS?5I can be used as cutoff in diagnosing PTSD using CPSS 51. Conclusion: CPSS-5I is extremely well designed, helpful and functional tool used in diagnosing PTSD. With the current study showing CPSS-5I can be used in post-COVID PTSD diagnosis, it also provides cutoff which can be helpful in mass screening.