One-stop intravitreal injection model: expert consensus on establishment and management / 中华眼底病杂志

Intravitreal drug injection is a treatment for common chronic fundus diseases such as age-related macular degeneration and diabetic retinopathy. The "14th Five-Year" National Eye Health Plan (2021-2025) recommends focusing on fundus diseases and improve the management mode of patients with chronic eye diseases. Therefore, it is imperative to explore how to further optimize the service process of intravitreal injection under the premise of guaranteeing patients' medical safety, to promote medical service efficiency and standardized management level and improve the medical experience of patients. Based on the quality control standard of vitreous cavity injection for retinopathy in China, Chinese fundus disease and related field experts developed the present expert consensus on the establishment of a one-stop intravitreal injection model and the management of its organization after a serious, comprehensive, and complete discussion, focusing on a standardized operation process, quality control, and safety management, providing more references for establishing a suitable intravitreal injection management model for ophthalmology and promoting the development of diagnostic and treatment models for fundus disease in China.

Study on five efficacy components, geoherbalism of Cistanche deserticola from genuine producing area in different collecting seasons / 中草药

Objective To investigate the contents of major five functional components (echinacoside, verbascoside, galactitol, betaine, soluble polysaccharide, and extractums) in Cistanche deserticola harvested in spring and autumn from genuine producing area in Alax Banner of Inner Mongolia. Methods HPLC-UV was applied to measuring the contents of echinacoside and verbascoside. HPLC-ELSD was used for determining the contents of galactitol and betaine. UV-VIS was utilized for analyzing the content of soluble polysaccharide. Results The index components of two samples' harvested in spring and autumn were all up to the standard of Chinese Pharmacopoeia. The samples harvested in spring contain 12.21 mg/g, which was twice of the autumn samples and fourfold of the standard of Chinese Pharmacopoeia. Based on verbascoside and betaine, the content of spring samples was significantly higher than the autumn samples, which was up to thirtyfold and it had great fluctuation among samples; Based on soluble polysaccharide, the content of spring and autumn samples were all at a high level, especially autumn samples was up to 13.7%; Based on galactitol and extractums, the content of autumn samples was significantly higher than the spring samples. Conclusion The content of verbascoside in C. deserticola has great fluctuation among samples. C. deserticola, that is rich in galactitol and soluble polysaccharide that authentic inner quality characteristics are "Glossy, Heavy, Fleshy, Quality soft, Sweet". Nevertheless, the ample galactitol and soluble polysaccharide is the material basis of quality formation, it is more reasonable to add the soluble polysaccharide as one of the index component to evaluate its quality characteristics. The standard of Chinese Pharmacopoeia points out the moisture limit of succulent herb is 10% may not be reasonable. The further improvement of the standard of C. deserticola's quality or separation of C. deserticola was discussed in this manuscript.

HPLC Fingerprint of the Ingredients in Simiao Junyi Ointment / 中国药师

Objective:To establish an analytical method for HPLC fingerprint chromatography of Simiao Junyi ointment to provide basis for the quality control standard. Methods:The separation conditions were established to obtain the HPLC fingerprint chromatog-raphy of the main ingredients in Simiao Junyi ointment. The conditions were as follows:the chromatographic column was Ultimate C18-ODS(250 mm ×4.6 mm,5 μm), the mobile phase was acetonitrile-0.1% phosphate solution, the flow rate was 1.0 ml·min-1, the detection wavelength was 280 nm, and the column temperature was 35℃. The common peaks in the chromatography were analyzed for their belongings. Results:Gradient elution was performed under the above optimal separation conditions, the constituents in Simiao Ju-nyi ointment were separated from each other perfectly, and the optimal fingerprint chromatography was obtained. Though the methodolo-gy examination, the indicators such as precision, stability and repeatability of the method were all promising, and the fingerprint chro-matography could be seen clearly and was easy to be analyzed. The relationships between Simiao Junyi ointment and the common peaks of four medicinal materials in the fingerprint chromatography were preliminary determined, which provided important basis for the quali-ty control of Simiao Junyi ointment. Conclusion:The HPLC fingerprint chromatography of Simiao Junyi ointment can be used as an a-nalysis method for the quality control of Simiao Junyi ointment, which provides reference for the quality control standard for the finished product.

Discussion on Habitat Processing Method ofIndigo Naturalis / 世界科学技术-中医药现代化

Recently, there are many prominent problems about the quality ofIndigo Naturalis. To explore the underlying reasons, both ancient and modern herbal literatures were reviewed. Through the organization of recordings onIndigo Naturalis, the traditional process method required soaking and fermentation, stiring and depositing, foaming and shade drying. The currently usedIndigo Naturalis was mostly isolated and purified from crude deposit -“Cu-Dian.” The modern process technique ofIndigo Naturalis was gradually deviated from the traditional processing method. This paper also discussed the quality standards ofIndigo Naturalis. The author considered that the current standard on descriptions ofIndigo Naturalis characteristics was deviated from the traditional morphological features ofIndigo Naturalis, which should be further researched and verified. Therefore, this study provided certain references for the quality control and market supervision ofIndigo Naturalis.

Correlation between Drug Quality Control Standard and Drug Quality Evaluation / 中国药房

OBJECTIVE:To emphasis the importance to unceasingly upgrading of drug quality standard for drug quality and to arouse the attention of the related enterprises, medical institutions and governmental department to this matter. METHODS: The correlation between quality standard and drug quality was expounded systematically by citing examples and reviewing the pertinent literature, and the current status of drug quality standard in China was analyzed briefly. RESULT & CONCLUSION: Great importance should be attached to the evaluation of drug quality standard to improve drug quality standard level step by step and to ensure efficacy and safety of drugs.

Preparation and Quality Control of Qingyan Tea Bag / 中国药房

OBJECTIVE:To prepare Qingyang tea bag and establish the standard of quality control.METHODS:The Flos Lonicera and Radix Glycyrrhize were identified by TLC.The content of chlorogenic acid,the main active component in the tea derived from Flos Lonicera,was determined by TLCs.RESULTS:Linearity was found in the range from1.2?g～4.8?g of chlorogenic acid,r=0.9993;the average recovery was99.50%and RSD=2.39%.CONCLUSION:The method was found to be simple,precise and may be used for the quality control of the preparation.

Studies on standard for quality control of BINGGANKANG GRANULE (A compound herbal preparation for treatment of hepatitis C) / 中草药

Object The formulation of a standard for the quality control of BINGGANKANG GRANULE was studied Methods The presence of Fructus Ligustri Lucidi, Radix Astragahi, Rhizoma Polygoni Cuspidati, Radix Isatidis and Fructus Schisandrae Chinensis were identified by TLC The content of ginsenoside Rg 1, the main active principle in the granule derived from Panax quinquefolius L was assayed by TLCS Results Linearity was found in the range from 2 08～10 40 ?g of ginsenoside Rg 1, the average recovery was 97 64% and RSD=1 74% Conclusion The method was found to be highly sensitive, simple, precise and reproducible and may be used for the quality control of the granule

Quality control of Fuyankang Capsule / 中成药

AIM: To study the quality control of Fuyankang Capsule(Radix et Rhizoma Salviae Miltiorrhizae,Radix Paeoniae Rubra,Radix Scutellariae,etc.) METHODS: The presence of Radix Paeoniae Rubra,Herba Taraxaci,Radix Scutellariae,Rhizoma Polygoni Cuspidati were identified by TLC.The content of hydroxybenzyl laxticacid,dansensu in the capsule was assayed by HPLC. RESULTS: Linearity of dansensu was found in the range from 0.04 ?g to 0.20 ?g.The average recovery was 98.8% and RSD was 1.5%. CONCLUSION: The method is highly sensitive,simple,precise and reproducible and can be used for the quality control of the capsule.