1.
Chinese Traditional and Herbal Drugs
;
(24): 1883-1888, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-854488
RESUMO
Objective: To investigate the metabolites of α-hederin in feces of rats after ig administration. Methods: An UPLC-Q/Trap-MS method was used for the identification of metabolites of α-hederin in feces of rats after ig administration of α-hederin (150 mg/kg). Results: Seven metabolites were detected in rat feces, including demethylation of α-hederin (M1), 3-O-α-L-arabinopyranoside hederagenin (M2), hederagenin (M3), glucuronideconjugate of α-hederin (M4), and double bond bonus of α-hederin (M5, M6-1, and M6-2). Conclusion: α-Hederin experiences a variety of metabolic reactions in rat gastrointestinal tract, mainly including deglycosylation, glucuronidation, demethylation, etc.