Evaluation of Clinical Effect of Rabeprazole Combined with Teprenone Capsules in Treatment of Gastric Ulcer by Marking Targeting Biopsy and Leptin / 医药导报

Objective To evaluate clinical effect of rabeprazole combined with teprenone capsules in treatment of gastric ulcer by marking targeting biopsy and leptin.Methods A total of 118 patients with active gastric ulcer confirmed by endoscopy were randomly divided into two groups.Patients in the treatment group (n=60) were given rabeprazole 10 mg,bid,and teprenone capsules 50 mg,tid.Patients in the control group (n=58) were given rabeprazole 10 mg,bid.Both groups were treated continuously for 56 days.Before and after treatment,2 groups were labeled with biopsy,the clinical efficacy and the healing rate of two groups were recorded,the quality of healing and the expression of leptin were compared.The level of leptin was tested after treatment.Results After 10 days,the difference of clinical curative effect was not statistically significant (P>0.05).After 56 days,the difference of clinical curative effect was statistically significant (P<0.05);ulcer healing rate (93.33%)in treatment group was higher than that of control group (72.41%);ulcer healing quality (93.33%) in treatment group was higher than that of control group (58.62%);leptin level of treatment group was lower than that of the control group;gastric ulcer recurrence rate (3.8%) in treatment group was lower than that of the control group (24.0%) (all P<0.05).Conclusion Rabeprazole combined with teprenone in the treatment of gastric ulcer is better than rabeprazole.Marking targeting biopsy and leptin can be used to evaluate the healing quality of gastric ulcer more accurately,which can be an evaluation index of the quality of gastric ulcer healing and used as an indicator of the quality of gastric ulcer healing.

Preventive Effect of ω-6 Soybean Oil Fatty Emulsion on Gastric Ulcer in Rats / 医药导报

Objective To study the preventive effect ofω-6 soybean oil fatty emulsion on gastric ulcer caused by acetic acid in rat model, and investigate its mechanisms. Methods Thirty healthy rats were randomly and equally assigned to the following 3 groups:sham operation,gastric ulcer,andω-6 Soybean oil fatty emulsion group.The model was induced by acetic acid. Five days after the model was established successfully,rats in ω-6 soybean oil group received the treatment by tail intravenous injection with the dose of 10 mL.kg-1 .d-1 ,the sham operation group and gastric ulcer group were given the same dose of 0.9%sodium chloride solution.The rats were sacrificed at 10th day after the treatment.The pathological changes of rat gastric ulcer tissue were observed by HE staining, and the concentration of gastric acid was detected by acid-base neutralization method,as well as the activity of pepsin was detected by colorimetry.Serum NO concentration was detected with nitrate reductive enzymatic method, and the expression of EGFR in gastric mucosal was detected with immunohistochemical method. Results Gastric ulcer area inω-6 soybean oil fatty emulsion group (5.67±2.32 mm2) was significantly lower than that in gastric ulcer group(8.68±1.98 mm2). The concentration of gastric acid (1.70±0.53 mmol.L-1), activity of pepsin(23.12±6.97 U) and NO level (64.62±13.86μmol.L-1 ) inω-6 soybean oil fatty emulsion group were much lower than those in the model control group.While the expression of EGFR in gastric ulcer tissue was increased after treatment withω-6 soybean oil fatty emulsion. Conclusion ω-6 soybean oil fatty emulsion exerts significant promotion effect on the healing of gastric ulcer,and its mechanism might be related to inhibiting the level of gastric acid, pepsin and NO, while improving the protective effect of EGFR on gastric mucosa.

Úlcera gástrica perforada ¿qué camino a seguir?: presentación de un caso y revisión de la literatura / Gastric ulcer perforated which path to follow?: report of a case and review of the literature

OBJETIVO: exponer un caso de ulcera gástrica perforada, clasificación, medios diagnóstico-terapéutico; resultados inmediatos, y repercusiones a largo plazo. SEDE: Hospital Municipal Los Pinos, Segundo Nivel La Paz, Bolivia DISEÑO: presentación de caso clínico INTRODUCCIÓN: la úlcera gástrica es pérdida circunscrita de tejido, se produce en áreas lábiles expuestas al jugo gástrico CASO CLÍNICO: paciente femenino de 78 años, realizado estudios imagenologicos y laboratoriales, evidencia cuadro compatible con ulcera gástrica perforada. Se realizó resección de bordes de la ulcera para biopsia, ulcerorrafia y parche de epiplón. El reporte patológico fragmentos de mucosa gástrica compatible con metaplasia intestinal e hiperplasia regenerativa atípica. Se solicita endoscopia digestiva alta informa: gastritis erosiva y biopsia para H. Pylori (+). Se inicia tratamiento para erradicación, nuevo control endoscópico el cual es normal y biopsia para H. Pylori (-). DISCUSIÓN: estudios básicos; como radiografía de tórax o abdomen mantienen vigencia en el diagnóstico de esta entidad. La cirugía puede ser por vía abierta o laparoscópica pero el estado clínico y la enfermedad comorbida dictan que procedimiento seguir; además debe erradicarse el H. pylori, porque se asocia en 70% a la úlcera gástrica.

OBJECTIVE: to present a case of gastric ulcer perforated classification, therapeutic means; immediate results and long-term impact. VENUE: Municipal Hospital Los Pinos, second level La Paz, Bolivia DESIGN: presentation of clinical case INTRODUCTION: gastric ulcer is circumscribed tissue loss, occurs in labile areas exposed to gastric juice clinical case: 78-year-old female patient, imaging and laboratory, evidence box compatible with gastric ulcer perforated. Held resection of edges of the ulcer for biopsy, suture of ulcer and patch of omentum. The report compatible with intestinal metaplasia and regenerative hyperplasia, atypical gastric mucosa pathological fragments. Apply for upper endoscopy reports: erosive gastritis and biopsy for H. Pylori (+). Begins treatment for eradication, new endoscopic control which is normal and biopsy for H. Pylori (-). DISCUSSION: basic studies; as x-ray of thorax or abdomen remains effective in the diagnosis of this entity. Surgery can be open or laparoscopic but clinical status and disease mobility dictate that procedure followed, also must be eradicated H. pylori, because he is associated gastric ulcer in 70%.

Ulcer gastric and Helicobacter pylori infection

Study on 335 cases underwent endoscopic biopsies. The results showed that: The rate of Helicobacter pylori (HP) infection in gastric ulcer patients that had clinical symptoms were 63%, highest in group of 31 to 50 years old. Inflammatory and ulcer lesions were in antropyloric area, and the rate of HP (+) was highest in this area. In comparison with endoscopic diagnosis, the highest ratio of HP was in gastric ulcer accompany with duodenal bulb ulcer, and lowest rate was in acute inflammation. There was no significant difference in infected frequency between male and female. However, moderate and severe infections (Hp2+, Hp3+) in men were more common than those in women

The relationship between the food restriction and the formation of experimental 8astric ulcer / 中国病理生理杂志

On the basis of Shay's ulcer model, we have studied the effects of food re. striction time on the experimental gastric ulcer in rats. The results indicat that each restricted group forms gastric ulcer after ligation of pylorus 18 hr. There are a postive correlation between the restricted time and the severity of gastric ulcer, and a negative correlation between the severity of gastric ulcer and the amount of gastric acid secretion. We suggested that Shay's ulcer model does not belong to peptic ulcer, but belonges to one of the stress ulcers. The restricted time may play an important role in the mechanism for this ulcer model.

THE CLINICAL SIGNIFICANCE OF DETERMINATION OF SERUM PEPSINOGENS Ⅰ AND Ⅱ / 解放军医学杂志

The results of determination of SPgⅠ and SPg Ⅱ in healthy subjects, some cases of gastrointestinal diseases and other diseases were reported. The level of SPgI was lower in the intestinal type of gastric cancer, but not in gastric type of gastric cancer. The severer the degree of atrophy in the gastric fundus glandular mucosa, the lower the level of SPgⅠ. levels of SPgⅠ, SPgⅡ were high in peptic ulcer, especially in the active stage of duodenal ulcer. In addition, low SPgⅠ, SPgⅡ levels were found in patients after gastrectomy or with cirrhosis, and very high levels were found in chronic renal failure. It is suggested that SPgⅠ, SPgⅡ values may be used as a new serological marker for the initial screening test for intestinal type of gastric cancer, for evaluation of the degree of atrophy of gastric glandular mucosa and for follow-up study of atrophic gastritis. It might also serve as a new serological parameter in the etio-logical as well as epidemiological study for duodenal ulcer.