Compuestos con potencial aplicación farmacológica obtenidos por biotransformación de geraniol y pineno / Compounds with potential pharmacological application obtained by geraniol and pinene biotransformation

Se presenta una revisión sobre los diferentes estudios reportados para la biotransformación de los monoterpenos geraniol y pineno, destacando la producción de compuestos naturales con aplicaciones farmacéuticas, y citando los resultados obtenidos en el Centro de Investigación en Ciencia y Tecnología de Alimentos de la Universidad Industrial de Santander. La biotransformación de geraniol empleando células de plantas, hongos y bacterias conduce a la producción de diferentes compuestos, entre los cuales sobresale el ácido geránico, reconocido por sus propiedades anticancerígenas. A partir del (R)-(+)-alfa-pineno y utilizando células de diferentes microorganismos se han producido principalmente verbenona y verbenol, compuestos usados como materiales de partida para sintetizar productos antitumorales.

This paper presents a review on the studies reported for the biotransformation of the monoterpenes geraniol and pinene, emphasizing in the production of natural compounds with pharmaceutical applications, and showing results obtained in the Research Center in Science and Technology Food of the Industrial University of Santander. The bioconversion of geraniol using plant cells, fungi and bacteria leads to the production of different compounds, among which outstands the geranic acid, recognized for its anticancer properties. From (R)-(+)-alfa-pinene and using cells from different organisms have been principally produced verbenona and verbenol compounds used as starting materials to synthesize anti-tumor products.

Flower scent analysis of Encyclia Vespa (vell.) Dressler & G. E. Pollard and E. Fragrans (Sw.) Lemée

The volatile constituents obtained from the pentane extract, using simultaneous distillation-extraction of the flowers of Encyclia vespa and E. fragrans were analysed by GC/ MS. The main volatile components identified in the flowers of E. vespa were terpinen-4-ol (20.3%), verbenone (14.8%), trans-verbenol (13.6%) and x-pinene (11.8%). The major volatiles of the flowers of E. fragrans were terpinen-4-ol (18.3%), (2Z,6E)-farnesol (15.4%) and trans-verbenol (10.2%).

Os constituintes voláteis obtidos dos extratos pentânicos das flores de Encyclia vespa e E. fragrans através de destilação-extração simultânea foram analisados por CG/EM. Os principais componentes voláteis identificados nas flores de E. vespa foram terpinen-4-ol (20,3%), verbenona (14,8%), trans-verbenol (13,6%) e a-pineno (11,8%). Os principais voláteis das flores de E. fragrans foram terpinen-4-ol (18,3%), (2Z,6E)-farnesol (15,4%) e trans-verbenol (10,2%).