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Objective:To explore the effects of game addiction disorders on brain cognitive control functions based on near-infrared spectroscopy.Methods:Thirteen subjects were screened according to the Online Game Addiction (OGA) Scale. The experimental paradigm was the stop-signal task. The relative concentration levels of oxyhemoglobin (HbO 2) and deoxyhemoglobin (Hb) in the prefrontal region of the brain during cognitive activity were collected using near-infrared spectroscopy to assess the cognitive control function of the subjects. Results:The game-addicted patients had lower keystroke accuracy in the stop-signal task than healthy subjects, and the difference was statistically significant ( P<0.05). Compared to healthy subjects, game-addicted patients had less activation in prefrontal areas and showed uncontrolled behavior and brain activity. Conclusions:Game addiction disorders impair brain cognitive control, which in turn triggers a weakening of cognitive control. The results of this study provide a reference for the prevention and treatment of game addiction.
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@#Abstract: Objective To explore the clinical characteristics of nucleic acid negative newborns delivered by pregnant women infected with SARS-CoV-2 (Omicron variant BA. 5.1.3) in Sanya area, and to provide evidence for understanding its clinical characteristics. Methods A retrospective analysis was performed on 14 neonates with negative nucleic acid delivered by pregnant women who tested positive for SARS-CoV-2 (Omicron variant BA.5.1.3) in Sanya Central Hospital (the Third People's Hospital of Hainan Province) from June 2022 to September 2022 (observation group, n=14). The corresponding nucleic acid-negative newborns delivered by pregnant women detected negative with SARS-CoV-2 (Omicronon variant strain BA.5.1.3) were set as the control group (n=56), and the general data and clinical characteristics of neonates in the two groups were compared. Results There was no significant difference between the observation group and the control group in pregnancy diabetes, pregnancy induced hypertension, gestational pre-eclampsia, fetal intrauterine distress, premature rupture of membranes (P>0.05); there was no significant difference between the observation group and the control group in terms of sex, gestational age, birth weight, age, mode of delivery, birth Apgar score, heart screening, pulmonary disease, glucose 6-phosphate dehydrogenase (G6PD) deficiency, thalassemia, breast milk jaundice, hemolytic jaundice (P>0.05). The bilirubin level, blue light irradiation cases and the duration of blue light irradiation of the newborns in the observation group at 7 days after birth were higher than those in the control group (P<0.05); the ratio of blood oxygen saturation ≥ 90% in the observation group was lower than that in the control group (21.43% vs 89.29%, P<0.05), and the ratio of blood oxygen saturation occasionally<90% was higher than that in the control group (57.14% vs 10.71%, P<0.05). The ratio of blood oxygen saturation<90% had no significant difference compared with that in the control group (7.14% vs 0, P>0.05), and the ratio of blood oxygen saturation reduced to the required oxygen uptake was higher than that in the control group (14.29% vs 0, P<0.05). Conclusions The jaundice manifestation of the nucleic acid-negative newborns delivered by pregnant women infected with SARS-CoV-2 (Omicronon variant strain BA.5.1.3) in Sanya area is relatively obvious, with blood oxygen saturation easily lower than 90% and even requiring oxygen inhalation in severe cases.
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【Objective】 To explore the protective effects of hemoglobin base on oxygen carries (HBOCs) with different oxygen affinity on isolated rat hearts. 【Methods】 Using Langendorff isolated heart perfusion model, 45 adult male SD rats (SPF grade), perfused with 30 min KH solution baseline, were randomly divided into sham operation group and control group: St. Thomas (STS) solution perfusion volume was 3mL/100g body weight; high P50 HBOCs group: [STS + high P50 HBOCs (P50=35.0 mmHg, 2.5 mg/100 g) product] perfusion volume was 3mL/100g body weight; medium P50 HBOCs group: [STS + medium P50HBOCs (P50=26.5.0 mmHg, 2.5 mg/100 g) product] perfusion volume was 3 mL/100 g body weight; low P50 HBOCs group: [STS + low P50 HBOCs (P50=11.0 mmHg, 2.5 mg/100 g) product] perfusion volume was 3mL/100g body weight, and the heart was arrested and placed in a 37℃ water bath to make the heart ischemic for 35 minutes, and then reperfused for 2 hours. The left ventricular development pressure (LVDevP), left ventricular end diastolic pressure (LVEDP), the rate of change of left ventricular pressure (LVPCR) and heart rate (HR) in the rat heart during reperfusion were observed and recorded. 1 min perfusion fluid from each rat in the basic and reperfusion phase was taken, and blood gas analyzer was used to measure the blood gas indexes of rats, and the myocardial injury marker enzymes [cardiac enzyme creatine kinase (CK-MB), lactate dehydrogenase (LDH) and the release of α-hydroxybutyrate dehydrogenase (α-HBDH)] were measured by ELISA kit. 【Results】 The cardiac function and the release of myocardial enzymes in the 5 groups of rats in the basal cardiac perfusion stage were similar (P>0.05). However, in the reperfusion stage, except for the insignificant changes in HR (P>0.05), the heart LVDevP (mmHg) of the three P50 HBOCs groups and the control group were 10.69±3.65 vs 8.50±2.88, 23.26 ±5.62 vs 8.50±2.88, 35.60±3.82 vs 8.50±2.88, LVEDP (mmHg) were 43.34±8.08 vs 54.64±7.42, 39.43±8.30 vs 54.64±7.42, 31.46±4.11 vs 54.64±7.42, dp/dt were 12.09±9.96 vs 6.09±0.98, 25.65±8.87 vs 6.08±0.98, 35.32±9.33 vs 6.09±0.98, -dp/dt were 17.53±11.28 vs 11.39±2.16, 28.80±13.70 vs 11.39±2.16, 43.36±3.83 vs 11.39±2.16, respectively (all P<0.05); the rebound situation and the release of CK-MB, LDH, and α-HBDH in the three P50 HBOCs groups were better than those in the control group (P<0.05). Among the three P50HBOCs products, the low P50HBOCs group had the best cardiac function indexes. The myocardial enzyme indexes of the high, medium and low HBOCs groups were CK-MB (ng/mL): 110.47±4.04, 90.2±2.46, 77.1±3.51; LDH (U/L): 162.23±7.71, 135.13±23.69, 92.20±4.21; a-HBDH (U/L): 228.00±8.03, 172.30±8.99, 131.00±2.02. 【Conclusion】 STS solution containing HBOCs products can improve the function of the reperfused heart at normal temperature ischemia for 35 min and 2 h reperfusion, and reduce heart damage. The STS solution containing low P50 HBOCs has the most obvious protective effect in rat isolated heart perfusion.
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OBJECTIVE@#To investigate the effect of obstructive sleep apnea (OSA) on different sleep stages, and the relationship between N3 stage of non-rapid eye movement sleep and respiratory abnormal events.@*METHODS@#A total of 188 adult patients who underwent overnight polysomnography(PSG)monitoring in Sir Run Run shaw Hospital of Zhejiang University from June 24th to December 26th 2019 were enrolled in the study. OSA patients were classified into 3 groups (mild, moderate and severe) according to the apnea-hypopnea index (AHI). PSG data, AHI and the lowest SPO in each stage of sleep were compared among three groups.@*RESULTS@#There was no significant difference in total sleep time and sleep efficiency among patients with different severity of OSA (all >0.05). The proportion of N3 stage in moderate and severe OSA groups were significantly smaller than that in mild OSA group (all <0.05). The proportion of N3 stage in severe OSA group was also smaller than that in moderate OSA group (<0.05). In addition, severe OSA group had a longer latency of N3 stage than mild and moderate OSA groups (all <0.05). The latency of N3 stage in moderate OSA group was longer than that in mild OSA group (<0.05). The AHI in N3 stage was markedly lower than that in other sleep stages (all <0.01), regardless of the severity of OSA. Supine AHI in N3 stage in mild and moderate groups was significantly lower than that in N1, N2 and rapid eye movement (REM) stages (all <0.01). Supine AHI in N3 stage in severe group was also lower than that in N2 and REM stages (<0.05 or <0.01). The lowest SPO in N3 stage was significantly higher than that in N1, N2 and REM stages (<0.05 or <0.01), regardless of the severity of OSA.@*CONCLUSIONS@#s The proportion of N3 stage is lower in OSA patients, and N3 stage has less sleep respiratory events than non-N3 stages. The results suggest that the increased N3 stage proportion may indicate less severity of OSA.
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Objective@#To explore the anesthetic effect of sufentanil combined with propofol with different target control concentration for breast cancer patients.@*Methods@#From January 10, 2015 to December 20, 2017, according to the digital table, 80 patients with breast cancer in the Maternal and Child Health Hospital of Cixi were randomly divided into three groups: group A(28 cases, the intraoperative sufentanil plasma target control concentration was 0.2ng/mL), group B (27 cases, the intraoperative sufentanil plasma target control concentration was 0.4ng/mL), group C (24 cases, the intraoperative sufentanil plasma target control concentration was 0.8ng/mL). The plasma target control concentration of propofol in three groups was 3μg/mL.The hemodynamic level[mean arterial pressure(MAP), heart rate(HR)], blood oxygen saturation(SpO2), recovery time, respiratory recovery time and incidence of adverse reactions were compared among the three groups.@*Results@#The MAP of T2, T3 and T4 in group A, group B and group C[T2: (78.56±7.42)mmHg vs.(76.98±7.65)mmHg vs.(69.36±7.69)mmHg; T3: (88.24±7.61)mmHg vs.(86.95±7.59)mmHg vs.(69.41±7.70)mmHg; T4: (72.32±7.51)mmHg vs.(69.24±7.21)mmHg vs.(66.52±6.85)mmHg], HR[T2: (73.65±8.75)times/min vs.(73.49±8.69)times/min vs.(68.36±7.79)times/min; T3: (76.75±8.95)times/min vs.(75.58±7.96)times/min vs.(68.65±7.36)times/min; T4: (71.42±7.41)times/min vs.(70.24±6.49)times/min vs.(64.39±6.62)times/min] showed significant differences[F(MAP)= 8.524, 15.365, 5.325; F(HR)=8.104, 12.521, 5.015, all P<0.05]. However, there were no statistically significant differences in SpO2 among group A, group B and group C in T2, T3 and T4(all P>0.05). There were no statistically significant differences in resuscitation time and respiratory recovery time among group A, group B and group C (all P>0.05). There was no statistically significant difference in the incidence of adverse reactions among group A, group B and group C(P>0.05).@*Conclusion@#0.8ng/mL sufentanil combined with 3μg/mL propofol has better anesthetic effect on patients undergoing breast cancer surgery, which is helpful to maintain hemodynamic stability.
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Objective: To investigate the physicochemical properties of sodium carboxymethyl starch(CMS) and its effect on erythrocyte rheology and oxygen carrying function. Methods According to the requirements of Chinese Pharmacopoeia,the physicochemical properties were determined for CMS120,CMS380 and hydroxyethyl starch 130 (HES130),including pH value,osmotic pressure molar concentration and viscosity. Normal saline,CMS120,CMS380 and HES130 were mixed with whole blood(7:3,V/V),respectively,and the experimental groups were set as whole blood group,whole blood+normal saline(NSB)group,whole blood+CMS120(CMS120B)group,whole blood+CMS380 (CMS380B)group,and whole blood+HES130(HES130B)group. The colloid osmotic pressure,blood viscosity,eryth- rocyte deformation and aggregation,and the partial pressure of oxygen when blood oxygen saturation was 50%(P50)val- ue were measured for each of these groups. Results: The osmotic pressure molar concentration and the viscosity of CMS120 and CMS380 were both significantly higher than those of HES130(all P<0.05)as indicated by the determina- tion of physicochemical properties. Compared with the whole blood group,the colloid osmotic pressure was significantly increased in the CMS380B and CMS120B groups(P<0.05),which was also significantly higher than that in the HES130B group(P<0.05). At low shear rate(10/s),compared with the whole blood group,the whole blood and the plasma vis- cosities were significantly increased in the NSB,CMS380B and CMS120B groups(all P<0.05),but the whole blood viscosity was significantly decreased in the HES130B group(P<0.05). Under the conditions of shear rate 10/s,50/s and 150/s,compared with the HBS130B group,the whole blood and the plasma viscosities were both significantly in- creased in the CMS120B and CMS380 groups(all P<0.05). At the effect of high shear rate,both the CMS380 and HES130 groups showed a tendency to promote erythrocyte deformation,and the CMS120B and CMS380B groups promot- ed erythrocyte aggregation,while the HES130B group inhibited erythrocyte aggregation amplitude(P<0.05). The P50 value was significantly higher in the CMS380B group than in the HES130B group(P<0.05). Conclusion: CMS130 and CMS380 could improve the rheological properties of erythrocytes and CMS380 could also promote the oxygen release of erythrocytes.
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This article describes the design of a portable blood oxygen simulation system that can be used to simulate various blood gas saturation states of the human body. The system can be used to simulate various states of blood gas saturation, and can also simulate large blood oxygen saturation dynamic range, pulse rate range and perfusion index range. It can be used for testing, but not for clinical examination instruments. Moreover, the system has the characteristics of small size and low cost compared with the commercial blood oxygen simulator. Although the simulation system is not directly used for the detection of blood gas saturation of patients, it is also an essential equipment in the production and testing process, so it has certain practical value.
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Humanos , Frequência Cardíaca , Oximetria , OxigênioRESUMO
Objective To develop a tracking monitor for patient vital signs after CT and MRI enhanced scanning so as to execute auto alarm in case of patient discomfort and allergic reactions.Methods The monitor composed of a sub machine,a principal machine and a large-screen display used ultra-low power digital blood oxygen plate LPDSPO2V1.4 and fingertip sensor to acquire data on blood oxygen saturation and heart rate,the acquired data were transmitted to the principal machine with NRF24L01 wireless transmission module, and then the principal machine executed data auto analysis, storage, auto alarm for out-of-limit data and sent the data to the display.Results The monitor could be used for checking blood oxygen saturation and heart rate as well as implement early warning against allergic reactions.One-year trials proved that there were no death in case 87 cases of minor allergic reactions and 3 severe ones occurred.Conclusion The monitor proves its safety and efficiency by decreasing the incidence rate of severe reactions after CT and MRI enhanced scanning,and thus is worthy promoting clinically.
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Objective@#To explore the relationship between physiological parameters changes and severe heatstroke induced by 5-km armed cross-country training.@*Methods@#A total of 521 male officers and soldiers from a special team who participated in the summer training of 5-km armed cross-country training from year 2016 to 2017 were enrolled. All trainees participated in 5-km armed cross-country training in high temperature and humidity environment of ambient temperature > 32 ℃and (or) relative humidity > 65%. The trainees were divided into two groups according to the incidence of severe heatstroke in the course of training. The age, enlistment time, constitution score, body mass index (BMI), external environment (ambient temperature, relative humidity, wind speed, heat index) of trainees of the two groups, and the change rates of arterial blood oxygen saturation (SaO2), body temperature, pulse and blood pressure within 5 minutes after the 5-km armed cross-country training were compared between the two groups. The risk factors of severe heatstroke were screened by two classified Logistic regression analysis, and the predictive value of various risk factors of severe heatstroke was analyzed by the receiver operator characteristic curve (ROC).@*Results@#In 521 trainees of 5-km armed cross-country training, 29 trainees suffered from severe heatstroke accounting for 5.57%. There was no significant difference in the age, enlistment time, constitution score, BMI, or external environment during 5-km armed cross-country training between severe heatstroke group and non-severe heatstroke group. Compared with those without severe heatstroke, the descending rates of body temperature, pulse, blood pressure and SaO2 increased rate within 5 minutes after 5-km armed cross-country training of severe heatstroke trainees were significantly decreased [temperature descending rate: (0.67±0.30)% vs. (1.43±1.28)%, pulse descending rate: (7.53±5.21)% vs. (13.48±8.07)%, blood pressure descending rate: (9.28±6.84)% vs. (19.42±7.73)%, SaO2 increased rate: (0.51±0.39)% vs. (1.50±1.43)%, all P < 0.01]. Two classification Logistic regression analysis showed that the temperature descending rate [odds ratio (OR) = 0.485, 95% confidence interval (95%CI) = 0.289-0.817], pulse descending rate (OR = 0.903, 95%CI = 0.845-0.965), blood pressure descending rate (OR = 0.841, 95%CI = 0.790-0.896), and SaO2 increased rate (OR = 0.421, 95%CI = 0.250-0.711) were the risk factors for severe heatstroke during 5-km armed cross-country training (all P < 0.01). ROC curve analysis showed that temperature descending rate [area under ROC curve (AUC) = 0.659, 95%CI = 0.604-0.714], pulse descending rate (AUC = 0.730, 95%CI = 0.762-0.900), blood pressure descending rate (AUC = 0.831, 95%CI = 0.659-0.801), SaO2 increased rate (AUC = 0.711, 95%CI = 0.655-0.767) could be used for the incidence of severe heatstroke prediction during 5-km armed cross-country training (all P < 0.01), and the predicted value was the same.@*Conclusions@#Under the same conditions, the severe heatstroke during 5-km cross-country training is closely related to the descending rates of body temperature, pulse, and blood pressure as well as SaO2 increased rate within 5 minutes after the training, whose predictive values for severe heatstroke were the same.
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@#AIM: To investigate the effect of crystal turbidity on retinal oxygen saturation in patients with diabetic cataract. <p>METHODS:This was a cross-sectional study. Totally 68 patients with 68 eyes of diabetic cataract admitted to our hospital from June 2017 to December 2017 were selected as subjects. Retinal oximetry was used to measure the blood oxygen saturation of the retinal veins, veins, and their supraorbital, nasal, subnasal, and infraorbital branches. The objective scatter index(OSI)of the eye was measured by Visual Quality Analysis System II, and the degree of opacity of the lens was graded according to OSI. <p>RESULTS:The blood oxygen saturation of the retinal artery and its branches in this group were 101.39%±10.84%, 106.19%±11.40%, 103.22%±10.91%, 102.36%±20.31%, and 101.29%±13.88%, respectively. The oxygen saturation of the retinal vein and its branches were 62.51%±8.95%, 66.37%±10.74%, 64.81%±8.97%, 58.37%±13.85%, and 58.66%±19.94%, respectively. The difference between arteriovenous oxygen saturation was 40.72%±12.08%. In this group of patients, 68 patients with 68 eyes had an OSI value of 4.21±3.14. Among them, 15 eyes were turbid at the first stage, 14 eyes were turbid at level 2, 23 eyes were turbid at level 3, and 16 eyes were turbid at level 4. Pearson correlation analysis showed that the retinal veins, veins and their branches were negatively correlated with OSI(both <i>P</i><0.01). The difference in retinal arterial and venous oxygen saturation was positively correlated with OSI(<i>P</i><0.01). There were significant differences in the blood oxygen saturation between the retinal veins, veins and their branches in patients with different degrees of lens opacity(<i>P</i><0.05). The retinal arterial, venous and branch oxygen saturation of patients with opacity of lens 4 was significantly lower than that of patients with opacity of lens 1, 2, and 3, and the difference was statistically significant(<i>P</i><0.05). There were no significant differences in blood oxygen saturation between the patients with opacity of lens 1, 2, and 3(<i>P</i>>0.05). There was no significant difference in the difference of arteriovenous oxygen saturation between the patients with different degrees of lens opacity(<i>P</i>>0.05).<p>CONCLUSION: In patients with diabetic cataract, when the degree of lens opacity is 1 to 3, the degree of abnormality of retinal blood oxygen metabolism is not obvious. When the degree of lens opacity reaches 4, the blood oxygen saturation of the retinal veins, veins and their branches will decrease.
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Objective To explore the clinical effect of SaO2and heart rate(HR)for the diagnosis of acute mountain sickness (AMS).Methods A total of 1 062 male soldiers on garrison duty in rapidly entering to high altitude at 3 700-5 400 m from May 2013 to August 2015 were included as the research subjects.The demography data were collected and the AMS symptoms investiga-tion was performed.SaO2and HR were detected and the relationship between SaO2and HR at different altitudes with AMS symp-tom score was analyzed.Results The cut-off value of SaO2for diagnosing AMS in rapidly entering to high altitude at 3 700-<4 300 m was 84.5%(AUC=0.781)with the screening sensitivity of 78.31% and specificity of 72.02%;which of HR for diag-nosing AMS was 89.5 times/min(AUC=0.640)with the screening sensitivity of 71.27% and specificity of 54.63%.When SaO2 was serially connected with HR,its sensitivity was 58.87% and the specificity was 89.23%,while the parallel connection yielded a sensitivity of 90.70% and a specificity of 37.43%.In rapidly entering the altitude at above 5000 m,the cut-off value of SaO2for di-agnosing AMS was 80.5%(AUC=0.825)with the screening sensitivity of 84.62% and specificity of 68.85%;which of HR for di-agnosing AMS was 93.5 times/min(AUC= 0.718)with the screening sensitivity of 53.00% and specificity of 85.25%;when SaO2was serially connected with HR,its sensitivity for diagnosing AMS was 47.01% and specificity was 93.44%,while the paral-lel connection yielded a sensitivity of 90.60% and a specificity of 60.66%.Conclusion SaO2combined with HR can serve as an ob-jective index for the on-site diagnosis of AMS and is convenient for the AMS preliminary screening of large populations.
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Aim: Stroke constitutes a considerable cause of morbidity and mortality in any society. Despite the increasing effect of stroke, information about the prophylactic effect of aerobics exercise on the health disorder in Ghana is rare. The objective of the study is to investigate the effect of aerobic exercise (AE) training on rehabilitative stroke patients considering their body mass index (BMI), resting systolic blood pressure (RSBP), resting diastolic blood pressure (RDBP), resting heart rate (RHR) and resting blood oxygen saturation (RSp02). Study Design: Quasi-experimental research design with pre-post test was employed. Place and Duration of Study: The study was conducted at physiotherapy clinic of Komfo Anokye Teaching Hospital, Kumasi, Ghana. The AE training and measurement were conducted from November, 2013 to April, 2014 in the gymnasium of the physiotherapy clinic. Methodology: The study comprised of fifty rehabilitative stroke [partial (36, 72.0%) and permanent (14, 28.0%)] patients with mean age of 54.04±13.07 years attending physiotherapy clinic. Age ranged from 26 to 80 years. The patients [male (27, 54.0%) and female (23, 46.0%)] went through moderate intensity, two sections a week of AE training for two months. Forty (80.0%) of the participants has experience in exercise programme while ten (20.0%) has none prior to the AE training programme. Physiological parameters of BMI, RSBP, RDBP, RHR and RSp02 were measured two days before and after the AE training period, and analysed. Results: The BMI (24.89±3.56 vs 23.11±2.89; t=9.237, p<0.05), RSBP (131.48±23.43 vs 120.94±7.42; t = 3.468, p<0.05), RDBP (87.70±16.03 vs 79.50±6.26, t = 3.577, p<0.05), RHR (84.22±8.47 vs 74. 22±3.80; t = 8.879, p<0.05) and RSp02 (93.44± 5.14 vs 96.56±1.98; t =-4.905, p<0.05) significantly changed after two months of AE training. There is significant difference in gender-based analysis on the effect of AE training on BMI (22.36 ±2.70 vs23.99±3.00; t=-2.058, p<0.05) and RDBP (81.63±5.83 vs 77.00± 5.92; t=2.779, p<0.05). There was no significant differences in the effect of AE training on physiological parameters analysed based on degree of stroke and exercise experience. Conclusion: AE training was effective on the BMI, RSBP, RDBP, RHR and RSp02 of rehabilitative stroke patients irrespective of gender and degree of stroke. Significance attention should be given to aerobic exercise in the rehabilitating process of stroke patients to minimize adverse affects of some drugs on their blood pressure, heart rate and oxygen saturation.
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Objective To evaluate the effectiveness of mild hypothermia and the intra-aortic balloon pump (IABP) in postcardiac surgical patients with severe heart failure. Methods Twelve patients took combination therapy of IABP and mild hypothermia after cardiac surgery, which did not improve the low cardiac output with massive doses of catecholamine, were included in this study. The values of cardiac index (CI), mixed venous oxygen saturation (SvO2), urine volume and creati-nine (Cr) were measured before and after treatment. Results After combination therapy of IABP and mild hypothermia, the value of CI was improved obviously [L/(min·m2):2.4±0.5 vs 1.6±0.2], the value of SvO2 increased (0.65±0.07 vs 0.52±0.05 ), urine output increased obviously [mL/(kg·h):2.9±1.9 vs 1.2±0.9 ] and the value of Cr decreased obviously (mmol/L:95±10 vs 282±25 ). Conclusion The combination therapy of mild hypothermia and IABP is an effective and simple procedure for the postcardiac surgical patients with severe heart failure.
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Objective To observe changes of erythropoietin (EPO) and rheology in moderate and severe obstructive sleep apnea hypopnea syndrome (OSAHS) patients after the noninvasive positive pressure ventilation (NPPV) treatment. Methods Healthy adults were selected as control group (n=40) while moderate to severe OSAHS patients were selected as OSAHS group. OSAHS group was underwent NPPV treatment then, Levels of sleep apnea hypopnea index (AHI), sleep mean minimum oxygen saturation (LSaO2) and serum erythropoietin (EPO) were assessed, routine blood test and hemodynam-ic indexes were also checked before treatment and 1 and 3 months after treatment in both groups. Results In both groups serum EPO, blood, blood rheology indexes, AHI, LSaO2 were analysised at each time point by ANOVA repeated measures, all of which show significant different between groups and between each time points within the same group. Indexes in OSAHS group improved with prolonged treatment , but they are in the normal range in the control. Conclusion OSAHS pa-tients with NPPV therapy can significantly relieve hypoxia, reduce serum EPO level and blood viscosity. So NPPV has impor-tant clinical significance in prevention and treatment of OSAHS.
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Objective To observe the change of cerebral oxygen metablism and the level of blood lactate in early stage of sepsis in rats.Method Sixty-four SD rats were randomly(random number)divided into septic group and control group.The sepsis model of rat was made by lipopolysaccharide (LPS,10 mg/kg)injected intra-abdominally,and rats of control group were treated with the same amount of physiological saline instead.And each group was further divided into 4 sub-groups of4 h,6 h,12 h and 24 h after treatment.At each interval,blood samples were obtained via jugular vein for detecting blood oxygen saturation (Sjv02)and blood lactate(LA).The blood oxygen saturation(Sa02)of ventral aorta was also measured.Arteriovenous oxygen content difference (AVD02) and oxygen extraction fraction (OEF) were studied.These four variables were analyzed and compared between two groups.Results The AVD02 and OEF in sepsis group were higher than those in control groups of 3 h,6 h and 12 h (P0.05).LA in sepsis group was higher than that in control group in each interval (P<0.05).Conclusions In early stage of sepsis,cerebral perfusion,cerebral oxygen supply and cerebral oxygen extraction increase.The global oxygen metabolic variables(Sjv02,AVD02 and OEF)and the level of LA can be used to objectively and accurately evaluate the cerebral oxygen metabolic dysfunction in early stage of sepsis.
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Objective:In order to detect blood oxygen saturation timely,accurately,and conveniently,a wireless blood oxygen saturation detection module has been developed.Methods:Based on wearable monitoring technology and ZigBee wireless communication technology,we designed a blood oxygen saturation module of finger cuff type.This system is composed of photoplethysmography detection micromodule,ZigBee access terminal,and data analysis program,which realize the functions of waveform display,SpO2 calculation,wireless date transmission and so on.Results:The results show that detection accuracy of photoplethysmography is 98%,and calculating error of SpO2 is less than 8.8% satisfying the performance index of blood oxygen saturation detection.Furthermore,ZigBee wireless communication technology and light source regulator can reduce energy expenditure effectively.Conclusion:With the characters of wireless,low power consumption,miniaturization,and high performance,it can truly reflect physiological condition of patients,and remove lines on them,which make it possible for mobile monitor.
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This work aims to create a methodology to analyse the physiological effects of people exposed to sounds, specifically music and its elements, using techniques of data acquisition and signal processing to provide objective information on the subjectsreactions, in order to help the use of music in music therapy for autistics. We used a pulse oximeter with data transmission capability, data acquisition and signal processing software. The subjects and/or groups were exposed to several types of music, varying its elements, and the physiologic measurement signals were made. The acquired information data base was then converted into graphics representative of heart rate and arterial hemoglobin saturation. During the measurements, the subjects behaviour has been observed to relate subjective and objective results. Two groups of subjects (six non autistics and six autistics with diagnosis established) participated on this research, with ages ranging from 7 to 24 years old. As the majority of autistics are male, only boys have been invited to participate of this study. An observation protocol based on autistics behaviour was developed, the vital signals and the subjects reactions were observed and recorded. The results allow to identify and establish in an objective way any influence of music in human behaviour through sound stimulation and vital signals monitoring: SpO2 and HR.
O objetivo deste trabalho foi criar uma metodologia que possibilite analisar os efeitos fisiológicos produzidos pela exposição de pessoas à música e seus elementos, utilizando princípios de detecção, aquisição de dados e processamento de sinais, obtendo-se informações objetivas sobre as reações dos sujeitos, para dar subsídios ao emprego da música na musicoterapia com autistas. Foram utilizados um oxímetro de pulso com capacidade de transmissão de dados e aplicativos para aquisição de dados e processamento dos sinais. Foram realizados experimentos com a exposição dos sujeitos a vários tipos de músicas, com a variação de seus elementos, criando-se, assim, um banco de dados com as medições realizadas, a seguir transformando essa informação em gráficos representativos da evolução dos sinais de FC e de SpO2. Durante as medições, o comportamento dos sujeitos foi observado para que o resultado da análise subjetiva fosse relacionado com as medições objetivas. Os sujeitos desta pesquisa encontram-se na faixa etária entre 7 e 24 anos, sendo que a amostra estabelecida foi composta por seis indivíduos não autistas e seis indivíduos com diagnóstico de autismo estabelecido. Como o maior percentual de autistas é do sexo masculino, apenas de sujeitos do sexo masculino participaram. Foi desenvolvido um protocolo de observação baseado no comportamento de autistas, e os sinais vitais foram adquiridos e processados. Como resultado, foi identificada de forma objetiva a influência da música no comportamento humano pelo monitoramento dos estímulos sonoros e dos sinais vitais de SpO2 e FC.
Assuntos
Frequência Cardíaca/fisiologia , Música , Monitorização Transcutânea dos Gases Sanguíneos , Musicoterapia/tendências , Oximetria , Transtorno Autístico/terapia , Estimulação Acústica , Potenciais Evocados Auditivos/fisiologia , Sinais Vitais/fisiologiaRESUMO
Objective To compare the effect of acupuncture and swallowing training on dysphagia in recove-ring stroke patients. Methods One hundred and thirty-two subacute stroke inpatients,73 males and 59 females,with a mean age of(67.9±9.0)years,26 cerebral hemorrhage patients and 106 cerebral infarct patients,participa-ted in the study.The patients were divided into a swallowing training group(ST,n=53)treated with thermal-tactile stimulation,deglutition exercises and food swallowing training;an acupuncture group(AP,n=48) treated with acu-puncture at the Fengchi(GB20),Lianquan(RN23),Bailao(EX-HN15),Jinjing(EX-HN12) and Yuye (EX-HN13)acupoints;and a control group(CG,n=31).The interventions were administered once a day,6 times a week.Before and after treatment,the patients were evaluated with a water-swallowing test and the"Any Two"test,and the arterial oxygen saturation(SpO_2) was monitored by pulse oximetry. Results The ST and AP groups showed significant improvement in water-swallowing and on the"Any Two"test after the treatment regimen,and were significantly better than the control group.There was no significant difference between the ST and AP groups.The average decrease in SpO_2 during water-swallowing was under 2%.After treatment,the baseline SpO_2 and post-water-swallowing SpO_2 of the ST group were significantly higher than those of the control group.The post-water-swallowing SpO_2 of the AP group was also significantly higher than that of the control group. Conclusions Acupuncture and swallowing training have similar effects in treating dysphagic stroke patients.Swallowing function and misaspiration cannot be predicted based on decreases in SpO_2.
RESUMO
Objective To study the effects of continuous passive motion(CPM)on tissue blood oxygen saturation(StO2)in the edge of wound after anterior cruciate ligament(ACL)reconstruction in rabbits.Methods Twenty male New Zealand rabbits,aged 8 months,received an ACL reconstruction by using double semitendinous tendon autograft in the right hind leg.The rabbits were randomly divided into 2 groups postoperatively,namely Cage activity group(n=10)and CPM group(n=10),treated with cage activity and activity by rabbit knee joint continuous passive motion apparatus respectively.On the following day after operation,a near-infrared optical device and ODISseyTM Tissue Oximeter were applied to measure the changes of tissue oxygen saturation(StO2)in the edge of the wound in each cycle(with flexion of 30?-110?)and various CPM speeds(2.35?/s,3.2?/s,and 8?/s),and the optimal CPM range and speed was thus selected for analyzing the changes of StO2 in local tissues of wounds with various angles of CPM in knee joint before the operation and on the 2nd,4th,6th,8th,10th,and 14th postoperative days.Results There was a significant difference with regard to StO2 between CPM group and Cage activity group(P0.05),however,a significant difference was observed among different time points(before the operation,and 2,4,6,8,10,14 days after the operation)(P
RESUMO
The operating principle of pulse blood oxygen saturation monitor is introduced. The usage and maintenance are discussed. Notice in using the instrument is suggested. The problem that the SPO2 detector is easy to damage is solved.