Effects of preoperative lipid metabolism indexes on the prognosis of patients with non-muscular invasive bladder cancer / 现代泌尿外科杂志

【Objective】 To investigate the effects of preoperative lipid metabolism level on the postoperative prognosis of non-muscular invasive bladder cancer (NMIBC). 【Methods】 Clinical data of NMIBC patients who underwent surgical treatment in our hospital during Mar.2014 and May 2021 were retrospectively analyzed. Based on receiver operating characteristic (ROC) curve, the optimal cutoff values of all lipid metabolism indicators were determined and patients were classified accordingly. The independent risk factors for postoperative recurrence were identified with Cox regression model. The survival was analyzed with Kaplan-Meier, and recurrence-free survival (RFS) was compared using log-rank tests. A recurrence risk prediction model was established based on the high-density lipoprotein (HDL) and other clinic pathological factors and the accuracy of prediction was evaluated with the area under the ROC curve (AUC). 【Results】 Cox multivariate analysis showed HDL, tumor number, tumor size and histological grade were independent risk factors for recurrence (P<0.05). Kaplan-Meier analysis showed that RFS was significantly longer in the high-HDL group than in the low-HDL group (P<0.001). Incorporating HDL, tumor number, tumor size, histological grade, and tumor stage into the recurrence risk model, the AUC was 0.706, and internal cross validation showed the AUC was 0.711. 【Conclusion】 Preoperative HDL is an independent risk factor affecting the RFS of patients with NMIBC, and combining it with clinic pathological factors will improve the prediction of tumor recurrence.

Study on the Effect and Mechanism of Allii Macrostemonis Bulbus on Blood Lipid Levels in Hyperlipi-demia Model Rats / 中国药房

OBJECTIVE:To investigate the effect and mechanism of Allii macrostemonis bulbus on blood lipid levels in hyperlipidemia model rats,and to provide reference for clinical use of Allii macrostemonis bulbus to reduce blood lipid. METHODS:A total of 10 normal rats were included in normal control group and given common diet. Other 50 rats were given hyperlipid diet to induce hyperlipidemia rat model. 40 model rats were randomly divided into model group(hyperlipid diet),Allii macrostemonis bulbus low-dose,medium-dose and high-dose groups(0.83,1.67,2.50 g/kg,fed by hyperlipid diet which containing 10%Allii macrostemonis bulbus 8.3,16.7,25.0 g/kg,fill with hyperlipid feed in patients with insufficient food intake). After fed for 45 d,the contents of TC,TG,LDL-C and HDL-C in serum of rats were detected. Liver,spleen,renal and cardiac indexes of rats were calculated. mRNA expression of low density lipoprotein receptor(LDLR)and liver X-receptor α(LXRα)were detected in liver tissue of rats. RESULTS:Compared with normal control group,the contents of TC and LDL-C in serum and liver index of rats were increased significantly in model group,while the content of HDL-C in serum and mRNA expressions of LDLR and LXR α in liver tissue were decreased significantly,with statistical significance(P<0.01). Compared with model group,the contents of TC and LDL-C in serum were decreased significantly in Allii macrostemonis bulbus groups,while the content of HDL-C was increased significantly. mRNA expressions of LDLR and LXR α in liver tissue were increased significantly in Allii macrostemonis bulbus medium-dose and high-dose groups,while liver and spleen indexes were decreased significantly,with statistical significance(P<0.05 or P<0.01). CONCLUSIONS:Allii macrostemonis bulbus shows good blood-lipid lowering effect,the mechanism of which may be associated with up-regulating mRNA expressions of LDLR and LXRα in liver tissue.

10-year Trend of Statin Use With its Impact Factors for In-hospital Acute Myocardial Infarction Patients in Eastern Urban China / 中国循环杂志

Objective: To assess the trend of statin application for in-hospital acute myocardial infarction (AMI) patients with its impact factors in eastern urban China from 2001 to 2011. Methods: A 2-stage random sampling design was performed to extract representative AMI sample patients. In the ifrst stage, a simple random-sampling was used to identify participating hospitals. In the second stage, a systematic sampling was conducted in 2001, 2006 and 2011 to select the cases from participating hospitals, to take medical records and clinical information for calculating the in-hospital statin application rate. The impact factors for statin application was assessed by multi Logistic regression model with generalized estimating equations. Results: A total of 5940 AMI records from 32 hospitals were enrolled. From 2001 to 2011, the in-hospital statin use rate increased from 46.0% in 2001 to 82.2% in 2006 and to 93.7% in 2011,P3.37 mmol/L were more likely to receive statin therapy than those with LDL-C<1.81 mmol/L (OR=1.59, 95% CI 1.10-2.30,P=0.013); the patients with chest pain at admission (OR=1.82, 95% CI 1.14-2.91, P=0.012), combining hypertension (OR=1.44, 95% CI 1.02-2.03,P=0.038), with in-hospital PCI (OR=2.99, 95% CI 1.71-5.23, P<0.001) were also more likely to receive statin therapy. The application rate of statin was reduced by reduced LDL-C level accordingly and the patients without LDL-C examination, accounting for 21.3%, had the lowest statin application rate. Conclusion: Statin therapy for in-hospital AMI patients was dramatically increased from 2001 to 2011 in eastern urban China and the guideline was rapidly popularized in clinical practice. However, the improvement has been needed especially in patients without LDL-C examination or with low LDL-C levels; we emphasize that AMI patients should receive statin therapy regardless their LDL-C levels.

Analysis on Peucedani Radix coumarin by UPLC/Q-TOF MS and study on its preliminary pharmacodynamics / 中草药

Objective: To establish a UPLC/Q-TOF MS method for analyszing the chemical constituents of total coumarins extract from Peucedani Radix (the rhizome of Peucedanum praeruptorum) and to study its preliminary pharmacodynamics. Methods: The chromatographic column was Acquity UPLC BEH C18, the mobile phase was composed of 0.1% formic acid (A) and acetonitrile (B) with gradient elution; The detection wavelength was set at 321 nm; The ionization mode was ESI+; And the mass scan range was m/z 100-1 000. Using the rat model of type 2 diabetes mellitus (T2DM) induced by streptozocin (STZ), the effect of total coumarins on reducing blood-lipid and blood-sugar was investigated in the experiment. Results: Qianhucoumarin D, peucedanocoumarin II, praeruptorin A, peucedanocoumarin I, praeruptorin B, and praeuptorin E in Peucedani Radix coumarin could be well separated and identified in one run. The preliminary pharmacodynamic results show that the total coumarins had an effect of reducing the level of fasting blood glucose, cholesterol, triglycerides, LDL, and liver index (P < 0.05); On the other hand, it could improve the level of HDL (P < 0.05). The above results prompt that coumarin extract of Peucedani Radix could improve the carbohydrate and lipid metabolism of T2DM, then play a role in the treatment of T2DM. Conclusion: A UPLC/Q-TOF MS method has been established to separate and identify the total coumarin extract of Peucedani Radix, the preliminary pharmacodynamic study shows that the total coumarin extract of Peucedani Radix had the function of reducing blood sugar and blood lipid significantly.

Effects of pregnancy induced hypertension on lipid metabolism and bilirubin metabolism in term neonates / 中国基层医药

Objective To observe the effects of pregnancy induced hypertension on lipid metabolism and bilirubin metabolism in term neonates.Methods 200 term neonates were selected and divided into the two groups,100 cases whose mother were healthy were control group and another 100 cases whose mother had gestational hypertension were observation group.Birth weight,measured in cord blood triglyceride (TG),total cholesterol (TC) levels,high density lipoprotein (HDL-C),low density lipoprotein (LDL-C),adiponectin (APN) level were recorded.Results Birth weight of the observation group had significantly lower birth weight (2 927 ± 492) g,than the weight of the control group (3 452 ± 348) g.The incidence of lower birth weight was higher than in the observation group.TG,LDL-C levels of the observation group were (0.6 ± 0.24) mmol/L,(1.95 ± 0.25) mmol/L,were higher than those of the control group[(0.39 ± 0.17) mmol/L,(1.95 ± 0.25) mmol/L].There was a statistically significant difference between the groups (t =12.35,2.35,P ＜ 0.01 or P ＜ 0.05).HL-C and APN of the observation group were lower than those of the control group (t =1.79,7.00,all P ＜ 0.05).Bilirubin after bomed 24 hours,48 hours,72 hours and bilirubin peak of the observation group were (8.64 ± 2.17) mg/L,(11.06 ± 3.12) mg/L,(10.32 ± 2.47) mg/L,(12.04 ± 2.13) mg/L and were higher than those of the control group [(3.06 ± 0.94) mg/L,(6.98 ± 1.56) mg/L,(7.26±1.89)mg/L,(9.64±1.98)mg/L](t=23.48,11.65,9.84,8.27,allP＜0.01).Conclusion Maternal PIH may affect birth weight,lipid metabolism and bilirubin metabolism.

Blood-lipid levels of 20041 kindergarten children aged 3 to 6 in Tianjin / 中华流行病学杂志

Objective To understand the level of blood-lipid and prevalence of dyslipidcmia of children aged 3 to 6 in Tianjin,so as to provide evidence for large-scale blood screening strategy and to develop intervention of dyslipidemia and cardiovascular in children.Methods 20 041 children aged 3 to 6 from 48 kindergartens were involved in this study,in Tianjin.Peripheral blood was collected from right leech-finger of these children,after fatless breakfast.Total cholesterol (TC) and triglyceride (TG) of plasma were tested using Toshiba 120 Automatic Biochemical Analyzer.Results The average levels of TC and TG were (4.17 ±0.69)mmol/L and (0.86±0.44) mmol/L in these children.11.4％ of the children had either TC or TG dyslipidemia,with 7.1％ had only TC dyslipidemia,4.9％ had only TG dyslipidemia,and 0.6％ of them had both TC and TG dyslipidemia.The prevalence of TC dyslipidemia was significantly higher among girls than boys.The prevalence rates of TC dyslipidemia and TG dyslipidcmia were different among age groups,but with no significant changes among age groups.The prevalence of TG dyslipidemia was significantly different,with obese children higher than those with normal or overweight children.Different residential areas seemed to be related to the difference on the prevalence of dyslipidemia.Prevalence of TC dyslipidemia was higher in urban than in rural areas.Prevalence of TG dyslipidemia was higher in rural than urban areas.Conclusion The prevalence of dyslipidemia for children aged 3 to 6 was high in Tianjin,and showed differences among genders,age groups and residential regions.Screening and intervention programs on dyslipidemia should be undertaken routinely in children,in order to prevent adult atherosclerosis and coronary heart disease.

Effect of probucoi on the vascular endothelial function of old patients with isolated systolic hypertension / 中国基层医药

Objective To evaluate the effect of probucol on endothelium-dependent vasodilatation(i,e.flow- mediated dilation,FMD) function of the old patients with isolated systolic hypertension.Methods In this single- blind study,a total of 64 old pariems with isolated systolic hypertension were randomized to receive conventional an- tihypertensive therapy and probucol (0.5g twice daily,group A,n=33) or receive conventional antihyperrensive therapy(group B,n=31) for 12 weeks.The levels of blood lipid were measured and vascular endothelial function was assessed in the brachial artery by high-resolution ultrasound technique in form of endothelium-dependent vasodi- latation before and after treatment.Results After 12-week treatment,the levels of TC,LDL-C and HDL-C in group A were significantly reduced compared with those before treatment(all P0.05).Flow-mediated dilatation parameters in both groups were obviously improved compared with those before treatment( P

Effect of Lovastatin on carotid atherosclerotic plaques, levels of blood lipid and serum C-reactive protein / 临床神经病学杂志

Objective To observe the effect of Lovastatin on carotid atherosclerotic plaque(CAP),levels of blood lipid and serum C-reactive protein(CRP) in patients with cerebral infarction(CI).Methods 120 CI patients with CAP were randomly divided into Lovastatin group and control group.At the basic of low fit diet for the two groups,Lovastatin was taken with 20 mg once a day for 6 months in Lovastatin group.Then,the changes of paque score,the levels of CRP and blood-lipid were observed 8 weeks and 6 months after treatment.Results (1)6 months later,the plaque score(4.20?3.77) in the Lovastatin group was significantly lower than pro-treatment(4.77?2.31)and the control group(6.86?1.89) (all P

Study on Extraction Technique for Blood Lipid Lowering Effective Components in Rhizoma Alismatis / 中国药房

OBJECTIVE: To screen the optimal extraction technique for the blood-lipid lowering effective components in rhizoma alismatis.METHODS: In an orthogonal test, the influence of 4 factors: alcohol concentration, extraction time, extraction frequency, and alcohol dosage, on the extraction was investigated by using the value of ultraviolet absorption of total triterpenes sapogenins in rhizoma alismatis as the investigated index.RESULTS: The optimal extraction technique for blood-lipid lowering effective components in rhizoma alismatis was to extract the medicinal material in 90% alcohol 5 times the amount of the material for 2 times with 2 hours for each time.CONCLUSION: The extraction technique is reasonable and practicable.

Study of the Mechanism of Cassia Obtusifolia L in Decreasing Blood-lipid / 中国药房

OBJECTIVE:To study the mechanism of Cassia obtusifolia L in decreasing blood-lipid.METHODS:Primary cultures of rat hepatocytes in vitro were used to determine the concentrations of proteins in hepatocytes by the method of Folin-phenol reagent and to assay the cholesterol synthesis from 14 C-acetate with liquid scintillation count.RESULTS:Ex?tract of Cassia obtusifolia L inhibited cholesterol synthesis from 14 C-acetate,but cassiaside B didn't affect cholesterol synthe?sis.CONCLUSION:The mechanism of extract of Cassia obtusifolia L in decreasing blood-lipid may result from inhibition of cholesterol synthesis,but inhibiting cholesterol synthesis may be not the main approach of cassiaside B in decreasing blood-lipid.

Investigation of the Relationship between Senile Cataractous Epidemiology and Blood- lipid / 第二军医大学学报

506 persons, over 45 years old, were observed; and 74 percent of them were found lens opacity. The proportion and degree of opacity were exacerbated with increased age. 51.6 percent of 375 persons with lens opacity had hyperlipemia while 18.3 percent of 131 persons with clear lens also had it. And hypertriglyceridemia was the major manifestation of hyperlipemia. It is suggested that hypertriglycendemia has a close relationship to cataract formation.

STUDY ON THE EFFECTIVE FRACTIONS DEPRESSING BLOOD-LIPIDS FROM OATS / 营养学报

Four fractions (starches, water insoluble proteins, water soluble fractions and residue) were separated from oats by means of filtration and repeated high speed centrifugation, and the lipids were extracted by acid-hydrolysis as well. Then each group of experiment hyperlipemic mice, caused by high lipid diet, were fed with these fractions for 10 days respectively. The results showed that the effectiveness of the residue fraction which was rich in dietary celluloses and lipids was similar to the whole oats on depressing bl-ood-lipid and that the water insoluble proteins were effective too. The lip-ids, however,were important but not unique effective composition in the residue of oats.