Preparation of ?-elemene solid lipid nanoparticles by film-ultrasonic wave dissolving techniques / 中草药

Objective To prepare ?-elemene solid lipid nanoparticles and investigate their particle size diameter and entrapment efficiency.Methods The ?-elemene solid lipid nanoparticles were prepared by film ultrasonic wave dissolving techniques.And the optimum formula was selected through orthogonal design test according to the entrapment efficiency.Results The optimizing technique was ?-elemene(20 ?L),stearic acid(90 mg),lecithin(90 mg),Tween80(2.5 %,5 mL) and Poloxamer 188(2.5 %,5 mL).Conclusion The technique of preparing ?-elemene by film-ultrasonic wave dissolving technique is feasible.

Preparation of curcumin solid lipid nanoparticles by film-ultrasonic method / 中成药

AIM: To optimize technique for preparing curcumin solid lipid nanoparticles by film-ultrasonic dispersion. METHODS: The influence of various factors,including the consumption of curcumin,stearic acid,lecithin and tween-80,and their effects on the entrapment efficiency and the ratio of loading drug were investigated.And the optimum formula was selected through uniform design test. RESULTS: Under the condition of 30 mg of curcumin,60 mg of lecithin,117 mg of stearic acid and 10 mL of tween-80(1.0%) curcumin solid lipid nanoparticals had good size distributions.The mean particle size diameter was 58.0 nm and the average entrapment efficiency and the ratio of loading drug approached 95.98% and 15.87%,respectively. CONCLUSION: The technique for preparing curcumin solid lipid nanoparticals N by film ultrasonic method is feasible.