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Objective To find the association between follicular output rate and clinical outcome in patients with polycystic ovarian syndrome (PCOS).Methods A total of 285 female patients with PCOS who were undergoing in vitro fertilization-embryo transfer (IVF-ET) for the first time were included in the study and were divided into three groups according to follicular output rate (FORT) values.The general information,the parameters of the controlled ovarian hyperstimulation,and clinical outcomes were compared.Results The concentration of serum E2 on the day of HCG,preovulatory follicle count (PFC),the number of retrieved oocytes,good-quality embryo rates,clinical pregnancy rate decreased sequently in groups with high,mediate and low FORT value.The incidence of moderate and severe ovarian hyper-stimulation syndrome (OHSS) in the group with mediate FORT value was significantly lower than that of groups with high and low FORT value.The incidence of severe OHSS in 3 groups with high,mediate and low FORT value was 20.6％,9％ and 17.8％ respectively and the difference was statistically significant (P =0.037).Conclusions The value of FORT may predict the clinical outcome of IVF/ ICSI-ET in patients with PCOS.Effort should be made to prevent OHSS in PCOS patients with high or low FORT value in their controlled ovarian hyperstimulation cycles.
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Objective To investigate the application value of double ovarian stimulations in the patients with low follicular output rate(FORT). Methods The data of 226 cases with low FORT at our hospital were ana-lyzed in this retrospective study. 67 patients received a subsequent luteal phase ovarian stimulation following regu-lar follicular phase stimulation(double stimulations group). The other 159 patients were performed fresh embryos transfer or whole embryos freezing(low FORT group),in which 60 patients who were not pregnant or had a pregnan-cy failure after fresh or freezing embryo transfer were served as control group and received conventional ovarian stimulation protocol in the next cycle. The clinical outcomes were compared among groups. Results The numbers of oocytes retrieved,metaphaseⅡoocytes,2PN fertilized oocytes,top-quality embryos in luteal phase stimulation were significantly higher than those in follicular phase stimulation(P < 0.05). Meanwhile,the parameters of IVF mentioned above along with cryopreserved embryos and the clinical pregnancy rate in double stimulations were sig-nificantly higher and the rate of abortion was significantly lower than low FORT group(P<0.05),which were simi-lar to control group(P > 0.05). Conclusions With the advantages of obtaining more available embryos in less time,the double stimulation could be served as an effective supplementary intervention for the patients with low FORT.
RESUMO
Objective To investigate the application value of double ovarian stimulations in the patients with low follicular output rate(FORT). Methods The data of 226 cases with low FORT at our hospital were ana-lyzed in this retrospective study. 67 patients received a subsequent luteal phase ovarian stimulation following regu-lar follicular phase stimulation(double stimulations group). The other 159 patients were performed fresh embryos transfer or whole embryos freezing(low FORT group),in which 60 patients who were not pregnant or had a pregnan-cy failure after fresh or freezing embryo transfer were served as control group and received conventional ovarian stimulation protocol in the next cycle. The clinical outcomes were compared among groups. Results The numbers of oocytes retrieved,metaphaseⅡoocytes,2PN fertilized oocytes,top-quality embryos in luteal phase stimulation were significantly higher than those in follicular phase stimulation(P < 0.05). Meanwhile,the parameters of IVF mentioned above along with cryopreserved embryos and the clinical pregnancy rate in double stimulations were sig-nificantly higher and the rate of abortion was significantly lower than low FORT group(P<0.05),which were simi-lar to control group(P > 0.05). Conclusions With the advantages of obtaining more available embryos in less time,the double stimulation could be served as an effective supplementary intervention for the patients with low FORT.