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Objective@# To investigate the inhibitory effect of honeysuckle on Streptococcus mutans UA159 in vitro.@*Methods@# We used a double-dilution method to measure the minimum inhibitory concentration (MIC) of honeysuckle against Streptococcus mutans UA159. Lonicerae lonicerae powder was dissolved in the solvent DMSO, different concentrations of liquid medicine were prepared, and bacterial liquid was added. The solution control group and bacterial liquid control group were set at the same time. The growth and acid production of UA159 were determined using antibacterial experiments. A growth curve and acid production curves were drawn, and the adhesion rate and adhesion inhibition rate were calculated. The effect of honeysuckle on the formation of Streptococcus mutans UA159 was determined by crystal violet quantification, and a microscope and a scanning electron microscope were used to observe biofilm formation and structural changes.@* Results @# The MIC of honeysuckle against Streptococcus mutans UA159 was 12.5 mg/mL. The bacteriostatic experiments showed a difference in the growth, acid production and adhesion of UA159 after honeysuckle treatment (P<0.05) compared with the controls, and the inhibitory effect increased as the drug liquid concentration increased. Crystal violet quantification showed a significant difference in biofilm formation between the pharmaceutical liquid group and the control group (P<0.05). Meanwhile, the forward microscope showed a significant decrease in biofilm formation. Under SEM, the number of bacteria decreased significantly at 0, 6 and 12 h after honeysuckle addition. @*Conclusion @# Honeysuckle inhibits the growth and acid production of UA159 and inhibits adhesion and the formation of biofilms.
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In 2013, the Government of Japan issued “Japan Revitalization Strategy”, in which facilitation of overseas expansion of Japanese drugs, medical equipment, health services, and health system through Public Private Partnership (PPP) is included. In alignment with this strategy, ministries and agencies have initiated on various health project, one of which is “Project for global growth of medical technologies, systems and services through human resource development”funded by the Japan Ministry of Health, Labour, and Welfare from 2015. As an administrative organization of this project, National Center for Global Health and Medicine (NCGM) has organized 119 project for 4 years from 2015 to 2018. This report summarizes the experiences and the results of evaluation in terms of program management, expansion of introduced health technologies and the health impact. As the results, the overall project management was satisfactory from the viewpoints of varieties of project, the execution rates. Then, health technologies were adopted in the national guidelines or policies and 17 introduced medical products were purchased by local governments. When it comes to health impacts, 19646 health staffs were trained through this program for 4 years and 912334 persons were estimated as beneficiaries by 29 project in 2017. Based on data shown as above, the overall achievement of this program should be considered satisfactory. Since this program is unique among other PPP program in Japan as well as other countries as the program scheme to promote expansion of medical products through human resource development, the experiences should provide some insights about the ways to facilitate PPP in health sector. In order to extract the Tips of good practices for future activities, further analysis on each project is necessary.
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Purpose: The mechanism of ocular growth eludes us and research on vitreous chamber depth (VCD) is lacking. The purpose of this study was to evaluate the role of VCD and its ratio to axial length (AL) in relation to ocular biometry. Methods: This retrospective study of patients planned for cataract surgery was performed at a tertiary center. Data regarding AL, anterior chamber depth (ACD), lens thickness (LT), and central corneal thickness (CCT) of 640 eyes was noted. Anterior segment (AS) was measured as sum of CCT, ACD, and LT, while VCD was calculated as the difference between AL and AS. Correlation of VCD and VCD: AL with ocular biometry was the primary outcome measure. Three groups were formed on the basis of AL and Pearson correlation coefficient (R) was applied. Results: Mean VCD was 15.38+/?1.14 mm. Mean VCD: AL was 0.66+/?0.02. VCD had a very strong relation with AL (R = 0.9, P < 0.001) only, whereas VCD: AL had a good--strong relation with AL (R = 0.5, P < 0.001), AS (R = 0.7, P < 0.001), ACD (R = 0.3, P < 0.001), and LT (R = 0.5, P < 0.001). The relation of VCD: AL with AS was very strong across all groups (R ? -0.8, P < 0.001 in all groups). 85% of eyes in group with AL <22 mm had VCD: AL <0.67, conversely 85% of eyes with AL >24.5 mm had VCD: AL >0.67. Conclusion: We found VCD to have the strongest relation with AL. VCD: AL was more consistent and showed a strong relation to ocular biometry across all ALs. This suggests the possible utility of the ratio VCD: AL while evaluating ocular growth, refractive status, and myopia-related complications.
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To improve the yield of industrial fermentation, a method based on near infrared spectroscopy was presented to predict the growth of yeast.The spectral data of fermentation sample were measured by Fourier-transform near-infrared (FT-NIR) spectrometer in the process of yeast culture.Each spectrum was acquired over the range of 10000-4000 cm1.Meanwhile, the optical density (OD) of fermentation sample was determined with photoelectric turbidity method.After that, a method based on competitive adaptive reweighted sampling (CARS) was used to select characteristic wavelength variables of NIR data, and then extreme learning machine (ELM) algorithm was employed to develop the categorization model about the four growth processes of yeast.Experimental result showed that, only 30 characteristic wavelength variables of NIR data were selected by CRAS algorithms, and the prediction accuracies of training set and test set of the CARS-ELM model were 98.68% and 97.37%, respectively.The research showed that the near infrared spectrum analysis technology was feasible to predict the growth process of yeast.
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Introducción: La recuperación del crecimiento de los niños prematuros se presenta en los primeros meses de vida y se termina en la adolescencia. El objetivo de este trabajo fue estudiar el crecimiento y desarrollo de una cohorte de adolescentes nacidos prematuros (1995-1996), en las ciudades de Chillán y San Carlos, Región del Biobío, Chile. Sujetos y método: Para el estudio se logró reclutar a 91 adolescentes de la cohorte original, lo que corresponde al 54%, y se incluyeron 91 controles adolescentes nacidos de término (ANT). Se evaluó el estado nutricional por índice de masa corporal para la edad y talla para la edad; composición corporal a través de pliegues cutáneos, riesgo cardiovascular por la presión arterial y circunferencia de cintura. Resultados: El 23,0% de adolescentes nacidos prematuros y el 24,1% de ANT tenía malnutrición por exceso, el 25,5% de los prematuros pequeños para la edad gestacional se encontraban con exceso de peso y el 14,5% de los adecuados para la edad gestacional. Presentaron talla baja un 16,5% de los adolescentes nacidos prematuros versus 5,5% de los ANT, encontrándose mayor proporción en mujeres (p < 0,04). Los adolescentes nacidos prematuros tenían más masa grasa que sus controles, en especial en el pliegue suprailíaco. No hubo diferencias significativas en la presión arterial ni en la circunferencia de cintura. Conclusiones: Los resultados indican que existe un grupo de adolescentes nacidos prematuros que no recupera la talla en la adolescencia, especialmente en las mujeres.
Introduction: Catch-up growth in preterm-born children occurs in the first months of life, but in some cases, growth recovery takes place in adolescence. The objective of this study was to study the growth and development of preterm-born adolescents from a cohort of preterm infants born between 1995 and 1996, who resided in the cities of Chillán and San Carlos in the Biobío Region, Chile. The results were then compared with term-born adolescents. Subjects and method: A sample of 91 children from the cohort was studied and compared with 91 term-born adolescents matched for gender, age, and attendance at the same educational institution. The nutritional status was assessed by BMI-for-age, height-for-age, body composition by skinfold, cardiovascular risk due to blood pressure, and waist circumference. Results: There was 23.0% and 24.1% overweight and obesity in preterm-born and term-born adolescents, respectively, with 25.5% of preterm-born and small for gestational age adolescents vs. 14.5% of those born adequate for gestational age were overweight. Lower height was observed in 16.5% and 5.5% of the preterm-born and term-born adolescents, respectively, and with a higher proportion of girls (P < .04). Preterm-born adolescents had a more fat mass than the controls, particularly in the suprailiac skinfold. No significant differences were found in blood pressure and waist circumference. Conclusions: The results indicate that there is a group of preterm-born children who do not recover height during adolescence, especially girls.
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Humanos , Masculino , Feminino , Recém-Nascido , Adolescente , Composição Corporal/fisiologia , Estado Nutricional/fisiologia , Sobrepeso/epidemiologia , Obesidade/epidemiologia , Estatura/fisiologia , Recém-Nascido Prematuro , Recém-Nascido Pequeno para a Idade Gestacional , Índice de Massa Corporal , Estudos de Casos e Controles , Chile , Fatores SexuaisRESUMO
treatments. Increasing nanoparticles concentration above 100 ppm reduced seed germination rate. It has not found any significant effects by bulk and nanoparticles on elongation of shoot, root and seedling of wheat. Application of 100 ppm concentration of nanosized Fe2O3 reduced mean germination time (MGT) by 38.5% in comparison to the control, while 100 ppm concentration of bulk Fe2O3 did not decrease MGT in comparison with the control. The highest root biomass was achieved from concentration of 100 ppm nano- Fe2O3, but an increased concentrations of nanoparticles Fe2O3 significantly reduced root weight. Nevertheless, on the basis of these results it is highly recommended that the influence of low dose nanomaterial be assessed in order to encourage seed germination and seedling growth.
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As a system,estrogen co-plays with growth hormone affecting the longitudinal bone growth.Meanwhile.estrogen receptors(ERα,ERβ,GPR30)are also involved in the regulation of the proliferation,mature and apoptOSis of the chondrocytes in the growth plate. It is well known that ERα promotes the clogure of the growth Mate.while it's emphasized by some latest articles that it is the genetic structure of ERβ that can disturb the expression of the ERα at certain level of serum concentration of estrogen.It regulates the physiological states of the bone growth as well as explains some pathological process. Some new progresses of GPR30 in this field are also summaried in this review.
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South America harbors the largest freshwater diversity in the world (about 4,475 valid species). Aging studies of 153 species published in 92 papers were reviewed for this publication. They were categorized according to the journal where they were published, decade, number of researches per river basin, methods and structures most used to estimate age, validation methods, period and causes of the formation of the age ring and age of the fish in South America. Our results showed an increase in the studies of age and growth, especially in the Paraná river basin. Scales were the structure most used in the studies of aging. Most of the researchers did not validate age. On a continental level, there was no specific period for growth ring formation, but in general, it was related to reproductive activity and flooding period. South American freshwater fishes did not present high longevity (maximum of 15 years). The ongoing governmental support to the fishery in South America, such as in Brazil with the creation of the Ministry of Fishing and Aquaculture, will certainly enlarge the fishing industry. Thus, it is necessary to know and to evaluate the fishery stocks correctly in order to guarantee sustainable use.
A América do Sul possui a maior diversidade de peixes de água doce do mundo (cerca de 4.475 espécies válidas). Para esta publicação, foi revisada a idade de 153 espécies de 92 artigos. Eles foram categorizados de acordo com o periódico, década, número de pesquisas por bacia hidrográfica, métodos e estruturas mais usadas para estimar a idade, métodos de validação, época e causas da formação do anel etário e idade dos peixes da América do Sul. Os resultados mostraram aumento de estudos de idade e crescimento, especialmente na bacia do rio Paraná. As escamas foram as estruturas mais usadas nos estudos considerados. A maioria dos pesquisadores não fez a validação da idade. Em nível continental não foi verificado um período específico para a formação dos anéis de crescimento, mas em geral, as marcas estiveram relacionadas com a atividade reprodutiva e ao período de cheias. Os peixes de água doce da América do Sul não têm elevada longevidade (máximo 15 anos). Na América do Sul, é esperado que a indústria pesqueira expandirá, pela criação de programas de incentivo, como a criação o Ministério da Pesca e Aquicultura no Brasil, e assim, será necessário conhecer e avaliar os estoques corretamente com o propósito de uso sustentável.
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Peixes , Crescimento e DesenvolvimentoRESUMO
South America harbors the largest freshwater diversity in the world (about4,475 valid species). Aging studies of 153 species published in 92 papers were reviewed forthis publication. They were categorized according to the journal where they werepublished, decade, number of researches per river basin, methods and structures most usedto estimate age, validation methods, period and causes of the formation of the age ring andage of the fish in South America. Our results showed an increase in the studies of age andgrowth, especially in the Paraná river basin. Scales were the structure most used in thestudies of aging. Most of the researchers did not validate age. On a continental level, therewas no specific period for growth ring formation, but in general, it was related toreproductive activity and flooding period. South American freshwater fishes did not presenthigh longevity (maximum of 15 years). The ongoing governmental support to the fishery inSouth America, such as in Brazil with the creation of the Ministry of Fishing andAquaculture, will certainly enlarge the fishing industry. Thus, it is necessary to know and toevaluate the fishery stocks correctly in order to guarantee sustainable use.
A América do Sul possui a maior diversidade de peixes de água doce domundo (cerca de 4.475 espécies válidas). Para esta publicação, foi revisada a idade de 153 espéciesde 92 artigos. Eles foram categorizados de acordo com o periódico, década, número de pesquisaspor bacia hidrográfica, métodos e estruturas mais usadas para estimar a idade, métodos devalidação, época e causas da formação do anel etário e idade dos peixes da América do Sul. Osresultados mostraram aumento de estudos de idade e crescimento, especialmente na bacia do rioParaná. As escamas foram as estruturas mais usadas nos estudos considerados. A maioria dospesquisadores não fez a validação da idade. Em nível continental não foi verificado um períodoespecífico para a formação dos anéis de crescimento, mas em geral, as marcas estiveramrelacionadas com a atividade reprodutiva e ao período de cheias. Os peixes de água doce daAmérica do Sul não têm elevada longevidade (máximo 15 anos). Na América do Sul, é esperadoque a indústria pesqueira expandirá, pela criação de programas de incentivo, como a criação oMinistério da Pesca e Aquicultura no Brasil, e assim, será necessário conhecer e avaliar osestoques corretamente com o propósito de uso sustentável.
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Animais , América do Sul , Peixes , Água DoceRESUMO
O objetivo deste artigo é introduzir elementos da reprodução econômica da sociedade capitalista na avaliação da dinâmica contemporânea da acumulação da saúde. São identificadas a direção e o sentido da acumulação de capital e o ambiente onde se desenvolvem os atuais processos de competição.O trabalho considerou a hipótese da hipertrofia da órbita financeira como um modo de estruturação da economia capitalista desde o último quartel do século XX, onde ficam embaçadas e corroídas antigas delimitações entre produção de bens e prestação de serviços. Mudam os padrões de competição entre as empresas, bem como as contradições internas e externas ao setor saúde. A abordagem é teórico-histórico-conceitual, visando aportar elementos para uma abordagem contemporânea do tema "complexo médico-industrial". São identificadas transformações internacionais e nacionais referentes à dinâmica do capital no complexo, com destaque para o crescente papel dos serviços. A nova abordagem é elaborada a partir do pensamento econômico de Marx, acrescido da discussão contemporânea sobre financeirização e novas configurações produtivas da grande empresa. Ao final, o caráter das contradições existentes no interior do complexo produtivo da saúde é problematizado.
The purpose of this article is to introduce elements of the capitalist society economic reproduction to the discussion around the current dynamics of health accumulation. It identifies the direction and significance of capital accumulation in the health area as well as the characteristics of the economic environment where the competition currently takes place. The hypothetic hypertrophy of the financial sphere is seen as a means for structuring the capitalist economy since the late twentieth century. The former delimitations between industrial production and service delivery are blurred and weakened; the competition process shows new features and the contradictions - internally between the different elements of the health industry and externally with other sectors - are changing. This article aggregates elements for a contemporary analysis of the "medical-industrial complex" on the basis of a theoretical-historical-conceptual approach. We identify changes in the capital dynamics of this complex at international and national level and stress the increasing role of the health services as a forefront of capital accumulation. The new approach is based on the economic thinking of Marx in addition to the current discussions about the theory of financial capital accumulation and the new productive configurations of the large corporations.
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Capitalismo , Atenção à Saúde/economia , Setor de Assistência à Saúde , BrasilRESUMO
[Objective]To study the effect of improved universal pedicle screw systems which combined locking pedicle screws with sliding pedicle screws to correct the spinal deformities in growth period through posterior incision.[Method]From June 2000 to June 2006,209 spinal deformities in growth period were treated(106 males and 103 females),including 92 idiopathic scoliosis,72 congenital scoliosis,26 Scheuermanns diseases and 19 other kinds of spinal deformities.The age of patients ranged from 8 to 16 years(average 13.22 years).Locking pedicle screws were placed into pedicles of apical vertebra and the 3 to 5 adjacent vertebrae.Sliding pedicle screws were putted into pedicles of cephalic and caudal vertebrae.Double cross-links and rods were fixed and locked tightly.Sliding cross-links themselves could cannula prolonged to fit for the transverse development of vertebrae.[Result]Totally 209 cases with preoperative Cobbs angle 45 degree to 110 degree(average 68 degree)were instrumented with improved USS systems and 96 cases were followed up for 26～60 month.The length of spines were prolonged 4 cm to 15 cm with average 7 cm.With 26 months to 60 months follow-up,the whole spine growth was 230.4 cm with average 2.4 cm respectively.Rods broken were found in 6 patients and no other cmplication was detected.[Conclusion]Improved USS system which combined locking pedicle screws with sliding pedicle screws had the three dimensional power and intensity of traditional 3D instrumentations.Sliding pedicle screws and cross-links permitted longitudinal growth of the vertebrae and transverse development pedicles.
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While studying skull base in craniosynostosis, it became apparent that there is a lack of reference studies quantifying the changes of the normal skull base throughout childhood. There is a considerable amount of work published already, obtained from skull radiographs with orthognathic deformities. While this has established some growth trends during childhood, it cannot easily be used for correlative studies, due to the known reliability and reproducibility errors that apply to all studies based on plain skull radiographs. This study presents simple measurement of brain CT and analysis of 2D growth of the skull base throughout childhood, which can be used as reference for further studies of condition that affect skull base growth, such as craniofacial deformities, in oriental childhood. The landmarks of skull base were identified on brain CT scan of 120 normal korean infants and children, aged 0 month to 24 months and several distances between the various landmarks were measured in an attempt to quantify the growth of skull fossa. The results of the measurements showed that at the age of 24 months, the distances reach 90% of adult values except for the anterior cranial fossa. This fossa only reaches 78% of the adult value which means that much potential remains at this age for further growth. There are two periods of time where total growth(total cephalic length) is the fastest: 0-9 months and 16-24 months. In regards to the anterior cranial fossa, 0-12 months is the period of fastest growth. The middle fossa grows fastest between 18-24 months. The posterior fossa follows a linear pattern with a constant rate of growth. or our measurements.
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Adulto , Criança , Humanos , Lactente , Encéfalo , Anormalidades Congênitas , Fossa Craniana Anterior , Craniossinostoses , Base do Crânio , Crânio , Tomografia Computadorizada por Raios XRESUMO
BACKGROUND: Because there is difficulty in the addition of known preservatives to oil in water emulsion such as propofol, ethylenediaminetetraacetic acid (EDTA) added to this may formulate for the antimicrobial activity; however, this formulation has side effects such as hyperlipidemia and pain on injection. We have developed a newly formulated poloxamer-solutol propofol which is considered to be free from hyperlipidemia. The aim of this study was to evaluate the possibility of bacterial growth in poloxamer-solutol formulated propofol compared to original propofol and EDTA added propofol. METHODS: Broth cultures (100nl) of four standard preservative efficacy test organisms (Staphylococcus Aureus, Pseudomonas Aeruginosa, Escherichia Coli, Candida Albicans) were added to 9.9 ml of four test formulations. Subjected formulations were original propofol (AstraZeneca Co, 1% solution, UK), EDTA added propofol (0.0055% EDTA added propofol), Poloxamer-Solutol formulated propofol (poloxamer 188/407 and solutol mixture), and normal saline at approximately 200 colony forming units/ml. The test formulations were incubated at 25degreesC and 32.5degreesC (Tryptic soy agar medium for bacteria and Sabrouraud dextrose agar medium for fungus) and tested for viable counts after 24 and 48 hours. RESULTS: Original propofol supported the growth of all microorganisms at both temperature and time. EDTA added propofol inhibited the growth of microorganisms more than the original propofol, but not so much as the poloxamer-solutol formulated propofol. Saline showed a similar pattern as EDTA added propofol. CONCLUSIONS: Poloxamer-solutol formulated propofol possesses more bacteriostatic activity against all four microorganisms than the original and EDTA added propofol.
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Ágar , Bactérias , Candida , Ácido Edético , Escherichia coli , Glucose , Hiperlipidemias , Propofol , Pseudomonas aeruginosa , TiramRESUMO
AIM: To explore the relationship between tumor progressing growth and synthesis of Bip/GRP78 in vitro. METHOD: Using tumor cell culture, ion exchange chromatography, SDS-PAGE, specific enzymatic, chemical catalysis, mass spectra and so on, the synthesis of Bip/GRP78 of cells growth in exponential, confluent and post-confluent phases was examined,and compared to normal breast epithelial cells. RESULTS: During the progressing growth, tumor cells' synthesis of Bip/GRP78 exhibited growth situation, cell density and malignant degree-dependent. CONCLUSIONS: During the progressing growth, tumor cells can maintain its homeostasis by synthesizing Bip/GRP78. This synthesis is intensely growth situation. Cell density and malignant degree-dependent. By this synthesis, tumor cell establishs its defensive system. Because increasing investigate results have shown that Bip/GRP78 can decrease the sensitivity of tumor cell to be killed by cytotoxic T lymphocytes, increase its tumorigencity and prevent its apoptosis. So aiming at destruction of the synthesis of Bip/GRP78 may point to a new approaches to the therapy of cancer.
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By studying the relationship between the morphology of mandibular symphysis and craniofacial morphology in class III malocclusion, this study aims at deciding whether the morphogy of mandibular symphysis can be used as a predictor on the growth of mandible. The materials used for this study were the cephalometric radiographs of male class III malocclusion. The subjected age groups were 10-12(G1 group) and 20 and above(G2 group); 50 were selected from each group. Each group was again divided, according to the ratio of symphysis, into Large(L), Average(A), and Small(S). The results of this study were summarized as follows: 1. In average the ratio of symphysis, G2 group showed significantly bigger than G1 group(P0.05). 3. In both G1 and G2 groups, there was not distinct difference in the antero-posterior positions among L, A, S subgroups. 4. L and A subgroups showed significantly larger than S subgroup in lower gonial angle and chin angle in G1 group (P<0.05) 5. In the measurements on the vertical relation of the face, anterior total face height(ATFH) and anterior lower face height(ALFH) of L subgroup were significantly larger than that of S subgroup in G1 group(P<0.05) and also mandible showed a tendency to grow downward vertically. 6. In the measurements on the tooth position and inclination, L subgroup showed as compared with S subgroup a tendency of extrusion of maxillary and mandibular teeth in G1 group, but G2 group showed such tendency only in mandibular teeth. 7. In the measurements on the abnormal growth prediction by Schulhof, in G1, there was no significant difference among L, A, S sugroups. 8. In the correlative analysis of the ratio of symphysis and other measurements, G1 group showed significant correlationships in chin angle, PP/MP angle, ANS-Me and other, while G2 group showed the same only in MP-LIT and MP-LMMC(P<0.05, P<0.01). In summarizing the above, in the G1 group, consisting of young males, no difference was noted in horizontal relation between L and S subgroups; in vertical relation, L subgroup showed a stronger tendency of downward growth of mandible than S subgroup. In adult male G2 group, however, no distinct morphological difference of craniofacial complex by the ratio of symphysis.
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Adulto , Humanos , Masculino , Queixo , Má Oclusão , Mandíbula , Base do Crânio , DenteRESUMO
By studying the relationship between the morphology of mandibular symphysis and craniofacial morphology in class III malocclusion, this study aims at deciding whether the morphogy of mandibular symphysis can be used as a predictor on the growth of mandible. The materials used for this study were the cephalometric radiographs of male class III malocclusion. The subjected age groups were 10-12(G1 group) and 20 and above(G2 group); 50 were selected from each group. Each group was again divided, according to the ratio of symphysis, into Large(L), Average(A), and Small(S). The results of this study were summarized as follows: 1. In average the ratio of symphysis, G2 group showed significantly bigger than G1 group(P0.05). 3. In both G1 and G2 groups, there was not distinct difference in the antero-posterior positions among L, A, S subgroups. 4. L and A subgroups showed significantly larger than S subgroup in lower gonial angle and chin angle in G1 group (P<0.05) 5. In the measurements on the vertical relation of the face, anterior total face height(ATFH) and anterior lower face height(ALFH) of L subgroup were significantly larger than that of S subgroup in G1 group(P<0.05) and also mandible showed a tendency to grow downward vertically. 6. In the measurements on the tooth position and inclination, L subgroup showed as compared with S subgroup a tendency of extrusion of maxillary and mandibular teeth in G1 group, but G2 group showed such tendency only in mandibular teeth. 7. In the measurements on the abnormal growth prediction by Schulhof, in G1, there was no significant difference among L, A, S sugroups. 8. In the correlative analysis of the ratio of symphysis and other measurements, G1 group showed significant correlationships in chin angle, PP/MP angle, ANS-Me and other, while G2 group showed the same only in MP-LIT and MP-LMMC(P<0.05, P<0.01). In summarizing the above, in the G1 group, consisting of young males, no difference was noted in horizontal relation between L and S subgroups; in vertical relation, L subgroup showed a stronger tendency of downward growth of mandible than S subgroup. In adult male G2 group, however, no distinct morphological difference of craniofacial complex by the ratio of symphysis.
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Adulto , Humanos , Masculino , Queixo , Má Oclusão , Mandíbula , Base do Crânio , DenteRESUMO
Taking the 8-year management practice of Sanjiu Brain Hospital of Guangdong since its founding as a case, the paper gives an account of how the hospital managed to grow by leaps and bounds. The steps taken include: guiding decision-making with innovations in thought and blazing new trails in such aspects as growth strategies, leadership structure, system of operation, quality control, nursing management, service skills, marketing management, hospital culture, and logistics management. The paper argues that innovation is the soul and driving force of hospital management and reform and that daring to and knowing how to make innovations are indispensable to enhancing the core competitiveness of the hospital and promoting its fast and sustainable growth.
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Patient with skeletal class II relationship was treated with L-ARS. L-ARS is fixed functional appliance that could be effective in children and adolescent patient who don't wear activator. The following results were obtained; 1) Growth of Mandible was stimulated and overjet was decreased, therefore coupling of anterior teeth was established with L-ARS which is fixed functional appliance. 2) These changes were accomplished with Mandibular skeletal growth with no effect on the Maxilla. 3) L-ARS was especially effective on patient who deny to wear the removable functional appliance.
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Adolescente , Criança , Humanos , Má Oclusão , Mandíbula , Maxila , DenteRESUMO
AIM To explore the relationship between tumor progressing growth and synthesis of Bip/GRP78 in vitro. METHOD Using tumor cell culture, ion exchange chromatography, SDS-PAGE, specific enzymatic , chemical catalysis, mass spectra and so on, the synthesis of Bip/GRP78 of cells growth in exponential, confluent and post-confluent phases was examined,and compared to normal breast epithelial cells. RESULTS During the progressing growth, tumor cells' synthesis of Bip/GRP78 exhibited growth situation, cell density and malignant degree-dependent. CONCLUSIONS During the progressing growth, tumor cells can maintain its homeostasis by synthesizing Bip/GRP78. This synthesis is intensely growth situation. Cell density and malignant degree-dependent. By this synthesis, tumor cell establishs its defensive system. Because increasing investigate results have shown that Bip/GRP78 can decrease the sensitivity of tumor cell to be killed by cytotoxic T lymphocytes, increase its tumorigencity and prevent its apoptosis. So aiming at destruction of the synthesis of Bip/GRP78 may point to a new approaches to the therapy of cancer.
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An experimental study on the effect of the induced avascular necrosis of the femoral head on the femoral anteversion was made in the hips of 74 three to four-week-old rabbits. The results were as follows; l. In 18 of the 74 operated rabbits, a relative increase of anteversion was observed on the operated side, as compared with the nonoperated femur, the differences ranging from 10 to 75°(average increase was 25.9°). 2. Anteversion increase was actually internal rotation of femoral shaft starting from the subtrochanteric level and progressively increasing downward with spiral fashion. 3. The cause of anteversion increase was not proved in this experiment, but anteversion increase was a result of avascular necrosis.