Contrast analysis of chemical constituents between single decoction and mixed decoction of Inulae Flos - Haematitum medicinal pair with different proportion / 国际中医中药杂志

Objective:To compare the differences of chemical components between single decoction and mixed decoction with different compatibility ratio of Inulae Flos- Haematitum medicinal pair. Methods:UPLC method was used to determine the contents of 5-caffeoylquinic acid, chlorogenic acid, 4-dicaffeoylquinic acid, caffeic acid, isoquercitrin, isochlorogenic acid B, 1,5- dicaffeoyl quinic acid, isochlorogenic acid C and the fingerprints of the single decoctions and mixed decoctions of Inulae Flos- Haematitum medicinal pair in four groups of proportions. The "peak area/sample weight" value of each common peak in the fingerprints was calculated, and the SPSS 26.0 was used for independent-sample t-test analysis. Results:There are significant differences in the "peak area/weight" values of peak 1, peak 2, peak 4, peak 6 , peak 9, peak 10, peak 12, peak 13, peak 15 between mixed decoction and single decoction of Inulae Flos - Haematitum medicinal pair with different compatibility ratios ( P<0.05), with statistical significance; when the compatibility ratio of Inulae Flos- Haematitum medicinal pair was 3:1, the difference of fingerprints and index components content between single decoction and combined decoction was the largest. Except for peak 7 and peak 14, the difference of "peak area/sample weight" value of other characteristic peaks was statistically significant ( P<0.05), and the content difference of 8 index components was statistically significant ( P<0.05). Conclusion:There are differences in the chemical components of Inulae Flos - Haematitum medicinal pair for single decoction and mixed decoction.

Preparo para alta de crianças com doenças crônicas: olhar freiriano em aspectos influenciadores do cuidado no domicílio / Preparing for the discharge of children with chronic diseases from hospital: looking at aspects influencing home care through a Freirean lens / Preparación para alta de niños con enfermedades crónicas: mirada freiriana en aspectos que influyen en el cuidado a domicilio

Estudo qualitativo que analisou aspectos envolvidos no preparo para alta hospitalar de crianças com doenças crônicas que influenciam o cuidado no domicílio. Dados das entrevistas de 25 famílias foram interpretados segundo análise temática indutiva e referenciais freirianos. Identificaram-se aspectos do processo de hospitalização, como engajamento e postura dos profissionais no encontro com os familiares e atitude da família frente ao saber dos profissionais; da família, como tempo de diagnóstico da doença, conhecimento construído na hospitalização, literacia em saúde familiar, atitude para superar o medo inicial e envolvimento da criança no autocuidado; e da rede social familiar, que influenciaram a (re)moldagem do cuidado domiciliar. Compreende-se a necessidade de superar a visão bancária no preparo para alta hospitalar, para a família desenvolver seu potencial e transformar a realidade dos cuidados domiciliares dessas crianças.(AU)

This qualitative study analyzed aspects influencing home care involved in preparing for the discharge of children with chronic diseases from hospital. Data from interviews with 25 families were interpreted using inductive thematic analysis and a Freirean frame of reference. We identified aspects of the hospitalization process (staff engagement and posture with family members, family attitudes towards health professionals' knowledge) and the family (length of time to diagnosis, knowledge gained during hospitalization, family health literacy, attitudes to overcoming initial fear, and child involvement in self-care and his/her social network, which influence (re)shaping of home care). The findings reveal the need to overcome the "banking" vision in preparing for hospital discharge so that families can develop their potential and transform the reality of home care for these children.(AU)

Estudio cualitativo que analizó aspectos envueltos en la preparación para el alta hospitalaria de niños con enfermedades crónicas que influyen en el cuidado en el domicilio. Se interpretaron datos de las entrevistas con 25 familias según análisis temático inductivo y referenciales freirianos. Se identificaron los aspectos del proceso de hospitalización: el compromiso y la postura de los profesionales en el encuentro con los familiares y la actitud de la familia ante el saber de los profesionales; de la familia: tiempo de diagnóstico de la enfermedad, conocimiento construido en la hospitalización, alfabetización en salud familiar, actitud para superar el miedo inicial y el envolvimiento del niño en el autocuidado; así como de su red social que influyeron en el (re)moldeado del cuidado familiar. Se comprende la necesidad de superar la visión bancaria en la preparación para el alta hospitalaria, para que la familia desarrolle su potencial y transforme la realidad de los cuidados en domicilio de esos niños.(AU)

Survey of oral health status and oral health knowledge of women preparing for pregnancy in Shanghai / 上海预防医学

ObjectiveTo explore the oral health status and oral health knowledge of women who are preparing for pregnancy in Shanghai so as to provide information on oral health. MethodsThe quota sampling method was adopted for 203 women preparing for pregnancy selected as the survey subjects in December 2019. Their oral health status was checked through oral examinations， and their awareness of oral health knowledge was investigated through questionnaire surveys. ResultsOral examination showed that in 203 women， the caries rate was 70.44%， the periodontal health rate was 4.43%， the dental calculus detection rate was 83.25%， the gingival bleeding detection rate was 59.61%， the shallow periodontal pocket rate was 9.85%， the deep periodontal pocket rate was 0.99%， and the detection rate of impacted teeth was 45.45%. The rate of women who answered all the questions in the questionnaire correctly was 0. ConclusionThe oral health of women preparing for pregnancy needs to be improved， and the level of oral health awareness needs to be raised urgently. The research results will help formulate and implement standardized oral health promotion policies.

Aposentadoria na perspectiva de trabalhadores do setor privado / Retirement from the perspective of private sector workers

A aposentadoria e a ruptura do vínculo de trabalho podem causar sofrimento aos trabalhadores. O objetivo desse estudo foi analisar a percepção sobre a aposentadoria de pessoas com idade a partir de 45 anos do setor privado e de profissionais de Recursos Humanos envolvidos em Programas de Preparação para Aposentadoria. A metodologia utilizada foi de caráter exploratório e, para a coleta de dados foram realizadas entrevistas semiestruturadas, classificadas em categorias apriorísticas e analisadas por meio da análise de conteúdo. Participaram da pesquisa vinte profissionais selecionados pela rede profissional da pesquisadora e pela técnica "Bola de Neve". Os resultados mostraram a percepção dos participantes quanto ao significado do trabalho como dedicação, realização, fonte de sustento e as perdas em decorrência da aposentadoria. Estas são: assistência médica, ausência da convivência com colegas de trabalho e financeiras. Constatou-se a importância dos Programas de Preparação para Aposentadoria, que oportunizam planejamento e estabelecimento de novos objetivos. Concluiu-se que a aposentadoria foi percebida pelos participantes como oportunidade de maior tempo disponível, qualidade de vida e saúde. Entretanto, demonstraram preocupação em relação ao aspecto financeiro e à manutenção da assistência médica.

Retirement and a break in employment can cause workers suffering. The objective of this study was to analyze the perception about retirement of people aged 45 and over in the private sector and of Human Resources professionals involved in Retirement Preparation Programs. The methodology used was exploratory and, for data collection, semi-structured interviews were carried out, classified into a priori categories and analyzed through content analysis. Twenty professionals participated in the research, selected by the researcher's professional network and by the "Snowball" technique. The results showed the participants' perception of the meaning pf work as dedication, accomplishment, source of support and losses due to retirement. These are the medical assistance, absence from coexistence with co-workers and financiers. The importance of the Retirement Preparation Programs was found to be an opportunity to plan and establish new goals. It was concluded that the retirement was perceived by the participants as an opportunity for more time available, quality of life and health. However, they showed concern regarding the financial aspect and maintenance of medical assistance.

Study on the attenuation mechanism of aristolochia manshuriensis compatibility with zingiberis rhizoma based on different methods of boiling and blending / 国际中医中药杂志

Objective Comparison of effects of Zingiberis Rhizoma and Aristolochia manshuriensis on diuretic effect and acute renal injury in rats by combining two methods of co-decoction and mixed-decoction. The effects of in vitro observation on normal human renal tubular epithelial cells (HK-2) were observed. Methods The rats were randomly divided into five groups: blank group, positive control group, aristolochia manshuriensis group, combined decoction group and divided decoction group, 8 rats in each group. The water-loading rat model was established by intragastric administration of normal saline. The urine of rats was collected and the volumes of urine were measured for 24 hours after the corresponding drugs were given to each group. After 2 weeks of gavage of the corresponding drugs in each group, the serum BUN, SCr and urine UCr and PRO levels were measured by 7600P automatic biochemical analyzer, and renal histopathology were observed by HE staining. The HK-2 cells were cultured in vitro and divided into control group, Aristolochia manshuriensis group, mixed decoction group and sub-decoction group. After 24 hour intervention, the activity of cells was detected by CCK-8 method and the apoptosis was observed by Hoechst stain method. Results There was no significant difference in 24 hour urine output between the groups (P>0.05). Compared with Aristolochia manshuriensis group, the kidney coefficient (0.010 1 ±0.005 8 vs. 0.013 3 ± 0.007 8), SCr (38.52 ± 0.58 μmol/L vs. 46.61 ± 0.72 μmol/L), BUN (8.55 ± 0.12 mmol/L vs. 10.21 ± 0.30 mmol/L), UCr (52.21 ± 0.89 μmol/L vs. 57.71 ± 0.67 μmol/L), PRO (29.89 ± 0.18 mg/L vs. 34.23 ± 6.05 mg/L) of combined decoction group significantly decreased (P<0.05). The survival rate of HK-2 cells (72.45% ± 3.70% vs. 55.92% ± 8.39%) in combined decoction group significantly increased (P<0.01), and the apoptosis rate (7.9% ± 2.6% vs. 31.6% ± 9.1%) significantly decreased (P<0.01). Conclusions The traditional co-decoction method of Aristolochia manshuriensis compatibility with Zingiberis Rhizoma can achieve a certain attenuation effect, and the mixed-decoction group can not achieve the attenuating effec.

Study on the attenuation mechanism of aristolochia manshuriensis compatibility with zingiberis rhizoma based on different methods of boiling and blending / 国际中医中药杂志

Objective@#Comparison of effects of Zingiberis Rhizoma and Aristolochia manshuriensis on diuretic effect and acute renal injury in rats by combining two methods of co-decoction and mixed-decoction. The effects of in vitro observation on normal human renal tubular epithelial cells (HK-2) were observed.@*Methods@#The rats were randomly divided into five groups: blank group, positive control group, aristolochia manshuriensis group, combined decoction group and divided decoction group, 8 rats in each group. The water-loading rat model was established by intragastric administration of normal saline. The urine of rats was collected and the volumes of urine were measured for 24 hours after the corresponding drugs were given to each group. After 2 weeks of gavage of the corresponding drugs in each group, the serum BUN, SCr and urine UCr and PRO levels were measured by 7600P automatic biochemical analyzer, and renal histopathology were observed by HE staining. The HK-2 cells were cultured in vitro and divided into control group, Aristolochia manshuriensis group, mixed decoction group and sub-decoction group. After 24 hour intervention, the activity of cells was detected by CCK-8 method and the apoptosis was observed by Hoechst stain method.@*Results@#There was no significant difference in 24 hour urine output between the groups (P>0.05). Compared with Aristolochia manshuriensis group, the kidney coefficient (0.010 1 ± 0.005 8 vs. 0.013 3 ± 0.007 8), SCr (38.52 ± 0.58 μmol/L vs. 46.61 ± 0.72 μmol/L), BUN (8.55 ± 0.12 mmol/L vs. 10.21 ± 0.30 mmol/L), UCr (52.21 ± 0.89 μmol/L vs. 57.71 ± 0.67 μmol/L), PRO (29.89 ± 0.18 mg/L vs. 34.23 ± 6.05 mg/L) of combined decoction group significantly decreased (P<0.05). The survival rate of HK-2 cells (72.45% ± 3.70% vs. 55.92% ± 8.39%) in combined decoction group significantly increased (P<0.01), and the apoptosis rate (7.9% ± 2.6% vs. 31.6% ± 9.1%) significantly decreased (P<0.01).@*Conclusions@#The traditional co-decoction method of Aristolochia manshuriensis compatibility with Zingiberis Rhizoma can achieve a certain attenuation effect, and the mixed-decoction group can not achieve the attenuating effec.

Study on Producing and Preparing Integration Process based on FreshCodonopsis pilosula Nannf.var.modesta (Nannf.) L.T.Shen / 中国中医药信息杂志

Objective To study the effects of different drying processes on the effective constituents in Wen Codonopsis pilosula (WPP) Decoction Pieces; To develop the optimized producing and preparing integration process based on fresh WPP.MethodsFresh WPP in harvest period was prepared respectively as follows:① Fresh WPP was dried to different percentage (30%–100%) of original moisture contents of crude drugs at 80℃ in oven, then sliced and dried at 50℃ to obtain eight decoction pieces of WPP (XⅠYP1–8).② The fresh WPP was baked to 50% of water content of crude drug under different temperatures (50–120℃), respectively, then sliced and dried at 50℃ to obtain eight decoction pieces of WPP (XⅡYP1–8).③ Dried WPP was moistened, sliced and naturally dried, then were renamed as traditional decoction pieces. The contents of lobetyolin and atractylenolideⅢ was determined by HPLC. The phenol-sulfuric acid and colorimetric method were applied respectively to detect contents of polysaccharide and total flavonoids. The contents of aqueous and alcoholic extracts were determined simultaneously. Results The contents of alcoholic extracts (55.36%), aqueous extracts (54.91%) and atractylenolideⅢ (10.95 μg/g) in XⅠYP3 pieces were higher than other decoction pieces.Conclusion The optimized process was that fresh WPP was baked to water content of 50% at 80℃, then sliced and dried. Compared with conventional preparing methods,the integration process was time-saving and effort-saving. Meanwhile, the prepared pieces have higher content of active ingredients.

Empirical study of alginate impression materials by customized proportioning system

PURPOSE: Alginate mixers available in the market do not have the automatic proportioning unit. In this study, an automatic proportioning unit for the alginate mixer and controller software were designed and produced for a new automatic proportioning unit. With this device, it was ensured that proportioning operation could arrange weight-based alginate impression materials. MATERIALS AND METHODS: The variation of coefficient in the tested groups was compared with the manual proportioning. Compression tension and tear tests were conducted to determine the mechanical properties of alginate impression materials. The experimental data were statistically analyzed using one way ANOVA and Tukey test at the 0.05 level of significance. RESULTS: No statistically significant differences in modulus of elastisity (P>0.3), tensional/compresional strength (P>0.3), resilience (P>0.2), strain in failure (P>0.4), and tear energy (P>0.7) of alginate impression materials were seen. However, a decrease in the standard deviation of tested groups was observed when the customized machine was used. To verify the efficiency of the system, powder and powder/water mixing were weighed and significant decrease was observed. CONCLUSION: It was possible to obtain more mechanically stable alginate impression materials by using the custom-made proportioning unit.

TECHNOLOGICAL STUDY OF PREPARING DICLOFENAC GEL / Монголын эм зүй, эм судлал

Introduction: It is required to develop drug formulations and increase local preparations substituting the import preparations. The utilization of a new drug formulation of diclofenac gel is an example of a medicine which is encouraged to be prepared locally. Diclofenac gel is a cyclooxygenase inhibitor, which is a non-steroidal anti-inflammatory drug (NSAID) taken to reduce inflammation and as an analgesic reducing pain in certain conditions. It is important to develop technology and standard for diclofenac gel type of medicine in Mongolia.In 2010, domestic manufacturers produced about 30- 40 percentage of demand in Mongolia. However, there are many manufacturers that produce the same type of medicines. This shows that there is a need for local manufacturers to meet local demand. It is an indication of urgency in bringing in new technologies, new drug formulations, activating drug research and scientific work in domestic drug industry.Based on research, in 2011, non-steroidal anti- inflammatory drugs were the most sold drugs, which had a market share of 29.2%. Also in 2010, non- steroidal anti-inflammatory drugs of gel formulation had a market share of 130 million Tugriks.In 2011, there were nine different manufacturers of diclofenac gel have been registered to Mongolian Medicine Registrar/LICEMED/. They are:-Clafen 1%-20.0 produced in Antibiotice Ltd, Romania-Feloran 1%-60.0 produced in Bаlkanpharma Troyan AD, Poland-Almiral1%-10.0/25.0 produced in Medochemie Ltd, Cyprian-Olfen 1%-20.0 produced in Mepha Ltd, Switerland-Voltaren 1%-20.0/50.0 produced in Novartis pharma,Switzerland-Dicloran Plus 1%-30.0 produced in Unique pharmaceutical laboratories, India-DiclofenacAcri 1%-30.0 produced in Acrihin Ltd, Russia-Diclovit 1%-20.0 produced in Nijpharm, Russia-Diclomol 1%-20.0 produced in Win Medicare Ltd, India.These gels are packaged between 20-60 grams and the are price ranges from 2,700-12,000 Tugriks.In the world, nowadays diclofenac gel is most commonly produced.Diclofenac gel is colorless, and it penetrates the affected area quickly and effectively. The gel has an advantage of delivering full drug concentration to the affected area quickly, while it is convenient and pleasant to use.Purpose of study: The purpose of study’s to develop a Diclofenac gel technology for the first time in Mongolia. In order to reach my purpose, which owe as follows:• To determine convenient ingredients and gel baseof gel formulations• To develop a layout explaining gel manufacturingtechnology• To formulate raw ingredients based on the developed of the gel• To develop an evaluation and quality control systemfor producing gelMaterials and methods: Research work was done at the Monos School of Pharmacy and Drug Research Institute.Triethanolamin and Glycerin from Tsetsuuh LLC, Diclofenac sodium, hydroxypropylmethylcellulose, and menthol from Monos Pharm LLC, Carbomer 940, Ultrez-21 and Propylenglycol from Monos Cosmetic LLC were used for this research.To determine the drug ingredient: To determine gel formulations, primary and secondary ingredients were chosen carefully to maintain chemical compatibility and stability.Developed gel formulation was checked forquality control, which includes drug content, pH,appearance/Homogeneity/, and viscosity by Russian Pharmacopoeia XI and Mongolian Primary Pharmacopoeia. Permeability studies and skin irritation test was performed by USP.Result: First, carbopol concentrations of 0.5%, 1.0%, 1.5% and 1.2%, Ultrez-21 concentrations of 0.5%,0.8%, and 1%, and hydroxypropylmethylcelluloseconcentrations of 3%, 4%, 5% were prepared as gel formulations.Of those, carbopol concentrations of 1.2% and 1.5%, and Ultrez-21 concentrations of 0.8% and 1.0% were relatively better compared to other concentrations in terms of meeting drug content, appearance, pH level, and viscosity requirements. 0.2 gram of Menthol was added to provide comfort and pleasant odor when gel is applied as well as providing release of diclofenac sodiumFinal products were compared to similar diclofenac gels in the market in terms of pH level, drug content, skin irritation, and release of active substance. Of those final products, Ultrez-21 concentration of 1% resulted to be the most similar to the diflofenac gels in the market that satisfy the qualities mentioned above.Conclusion:1. The Ultrez-21 1% is determined to be the best gelling agent and 0.2 gram of Menthol is determined to be the best amount for increasing drug permeability.2. Developed technological procedure for preparingdiclofenac gel.3. To determine criteria for quality control, gel drug content, appearance, pH and viscosity were shown to be the most convenient measures.

The Douyan Mixture Preparation and Clinical Application / 浙江中医药大学学报

ObjectivePrepare the Douyan mixture and observe its clinical curative effect. Method By the methods of decoction and concentration,we have prepared the Douyan mixture and carries on the curative effect observation to 150 cases of the sinusitis. ResultThe preparation of the Douyan mixture is simple,feasible and the quality is stable,total effectiveness is 94.7%. ConclusionThe preparation of this mixture is easy to operate,its quality is easy to control and the curative effect is definite.

A comparative study of the resistance to dislodgement of fixed prostheses using Bio-pin(R) / 대한치과보철학회지

STATEMENT OF PROBLEM: The current trend in prosthodontics is the adoption of a conservative approach to preparing dental prostheses by minimizing the amount of sound tooth structure removal during preparation. PURPOSE: The major disadvantage of the adhesion bridge is the inherently poor resistance to dislodgement that its use in areas subjected to high occlusal load is limited. The purpose of this study was to compare the dislodgement resistance of Bio-pin(R), conventional 3-unit and adhesion bridges. MATERIAL AND METHODS: The experimental groups were classified as follows: .Group I : 3-unit bridge cemented using Super-Bond. C&B .Group II : Adhesion bridge cemented using Super-Bond. C&B .Group III : Bio-pin(R) design adhesion bridge without incorporation of Bio-pin(R) (cemented using Super-Bond. C&B) .Group IV-1: Bio-pin(R) retained adhesion bridge incorporating a single Bio-pin(R) (cemented using Super-Bond. C&B) .Group IV-2: Bio-pin(R) retained adhesion bridge incorporating a single Bio-pin(R) (cemented using Panavia. F) .Group V : Bio-pin(R) retained adhesion bridge incorporating two Bio-pins. (cemented using Super-Bond. C&B) RESULTS: The results of this study were as follows: 1. Significant differences in dislodgement resistance of the restorations were found between Group I, Group II and Group III (p<0.05). No significant differences in dislodgement resistance of the restorations were observed between Group I, GroupIV-1 and GroupV. However, there were significant differences in dislodgement resistance between GroupII and the other groups (p<0.05). 2. No significant differences in dislodgement resistance of the restorations were observed between GroupIV-1 and GroupIV-2, both of which utilized a single Bio-pin(R). However, significant differences were observed when GroupIII was compared to either GroupIV-1 or GroupV (p<0.05). 3. No significant differences in dislodgement resistance relative to the type of dental cements used were found. CONCLUSION: From the above results, it is concluded that the dislodgement resistance of Biopin. bridge restorations utilizing a single Bio-pin(R) is similar to that of a conventional 3-unit bridge. The results also suggest that Bio-pin(R) bridge restorations using a single Bio-pin(R) are a viable alternative to the conventional 3-unit bridge when minimal removal of sound tooth structure and fulfillment of both function and esthetic aspects are considered.

Utilizing the preoperative preparing room to improve patients' mood and surgery rotation time / 医学研究生学报

Objective: Little has been reported on the utilization of the preoperative preparing room before anesthesia.This article aimed to investigate how to improve work efficiency in the operation theatre by utilizing the preoperative preparing room.Methods: Two hundred patients undergoing elective surgery were equally randomized into an operation room group and a preoperative preparing room group,for which the preoperative preparations were made in the operation room and the preoperative preparing room,respectively.Records were made of such parameters as the anxiety score,mean arterial pressure(MAP) and heart rate(HR) of the patients,as well as the surgery rotation time.Results: The anxiety score,MAP and HR were significantly lower(P

Effect of Different Processing Methods on the Content of Gallic Acid in Radix et Rhizoma Rhei / 中药新药与临床药理

Objective To establish a HPLC method for the determination of gallic acid in Radix et Rhizoma Rhei and to study the changes of gallic acid content in Radix et Rhizoma Rhei during processing. Methods HPLC method was used to detect gallic acid content. Diamonsil C18(250 mm?4.6 mm,5?m) column was used,and the mobile phase was a mixed liquid of MeOH -0.01 %H3PO4(10∶90). The column temperature was set up at 30℃,the flow rate was 1 mL?min-1,and the detecting wave-length was 273 nm. Results There were obvious differences of gallic acid content between the crude herbal material and different kinds of processed products of Radix et Rhizoma Rhei. The content of gallic acid was decreased in Radix et Rhizoma Rhei prepared by wine,but was increased in Radix et Rhizoma Rhei prepared by steaming with wine and by stewing with wine,and in charred Radix et Rhizoma Rhei. Conclusion The different processing methods have certain effect on the content of gallic acid in Radix et Rhizoma Rhei.

Preparation of ?-elemene solid lipid nanoparticles by film-ultrasonic wave dissolving techniques / 中草药

Objective To prepare ?-elemene solid lipid nanoparticles and investigate their particle size diameter and entrapment efficiency.Methods The ?-elemene solid lipid nanoparticles were prepared by film ultrasonic wave dissolving techniques.And the optimum formula was selected through orthogonal design test according to the entrapment efficiency.Results The optimizing technique was ?-elemene(20 ?L),stearic acid(90 mg),lecithin(90 mg),Tween80(2.5 %,5 mL) and Poloxamer 188(2.5 %,5 mL).Conclusion The technique of preparing ?-elemene by film-ultrasonic wave dissolving technique is feasible.

Preparation of curcumin solid lipid nanoparticles by film-ultrasonic method / 中成药

AIM: To optimize technique for preparing curcumin solid lipid nanoparticles by film-ultrasonic dispersion. METHODS: The influence of various factors,including the consumption of curcumin,stearic acid,lecithin and tween-80,and their effects on the entrapment efficiency and the ratio of loading drug were investigated.And the optimum formula was selected through uniform design test. RESULTS: Under the condition of 30 mg of curcumin,60 mg of lecithin,117 mg of stearic acid and 10 mL of tween-80(1.0%) curcumin solid lipid nanoparticals had good size distributions.The mean particle size diameter was 58.0 nm and the average entrapment efficiency and the ratio of loading drug approached 95.98% and 15.87%,respectively. CONCLUSION: The technique for preparing curcumin solid lipid nanoparticals N by film ultrasonic method is feasible.

Study on Processing for Rhizoma Pinelliae (Processed with Licorice and Lime)by Orthogonal Design / 中成药

The procedure for Rhizoma Pinelliae(Processed with Licorice and Lime) was combinatively evaluated by L_9(3)~4 orthogonal design with three factors:decocting times for Radix Glycyrrhizae,concentrated volume of decoction and macerating time. The optimum condition is as follows: each 100g of Rhizoma Pinelliae,accompanied with 15g of Radix Glycyrrhizae (decocted with water for two times,then the two decoctions were combined,and concentrated to 150ml.)and 10g of calx,was macerated in concentrated decoction of Radix Glyeyrrhizae for six days

Preparation and Clinical Observation of Sterilized Medical Bone Wax / 中国药房

OBJECTIVE:To prepare the sterilized medical bone wax and to establish the standard of quality control.METHODS:The bone wax was identified with chemical approach and the quality of bone wax was evaluated by saponification value.RESULTS:The bone wax was appropriate in formula,feasible in preparing technique and satisfactory in therapeutic efficacy with a satisfication rate of 98%.CONCLUSION:There are no obvious differences between the bone wax developed by our hospital and imported bone wax in quality,therefore the prepared bone wax can take the place of imported products.