Assessment of the efficacy of olopatadine 0.1% in the treatment of vernal keratoconjunctivitis in terms of clinical improvement based on total ocular symptom score and ocular surface disease index

Purpose: The main objective of this study is to explore the efficacy of olopatadine 0.1% treatment in the resolution of symptoms of vernal keratoconjunctivitis (VKC) among the Indian population. Methods: This single?center, prospective cohort study involved 234 patients with VKC. Patients were treated with olopatadine 0.1%, twice daily for a period of 12 weeks and then followed up in 1st week, 4th week, 3rd month, and 6th month. The extent of relief in the symptoms of VKC was measured using total ocular symptom score (TOSS) and ocular surface disease index (OSDI). Results: In the present study, the dropout rate was 5.6%. Total of 136 males and 85 females with a mean age of 37.68 ± 11.35 years completed the study. TOSS score reduced from 58.85 to 5.06 and the OSDI score reduced from 75.41 to 11.2 with statistical significance (P < 0.01) from 1st week to 6th week after olopatadine 0.1% treatment. The data showed relief in subjective symptoms of itching, tearing, and redness, and relief in discomfort in functions related to ocular grittiness, visuals like reading, and environmental like tolerability in dry conditions. Further, olopatadine 0.1% was effective in both males and females, and patients across ages 18–70 years. Conclusion: Based on TOSS and OSDI scores, the findings of this study validate safety and tolerability as revealed by low adverse effects and moderate efficacy of olopatadine 0.1% in reducing VKC symptoms in a broader age group (18–70 years) of both genders.

Analysis of adverse events following immunization of adsorbed acellular DPT vaccine at different vaccination sites / 上海预防医学

ObjectiveTo analyze the occurrence of suspected adverse events following immunization （AEFI） after changing the priority vaccination sites of the adsorbed acellular diphtherior-pertussis-tetanus vaccine （hereinafter referred to as DPT vaccine）， so as to provide scientific basis for mass vaccination. MethodsMonitoring data of AEFI for the DPT vaccine in Wujiang District from September 2020 to August 2022 were collected from China's disease prevention and control information system， and the vaccination information of DPT vaccine in all children's vaccination clinics in Wujiang District during the same period was selected. The incidence of AEFI for the DPT vaccine was analyzed and compared. ResultsThe reported incidence of AEFI was significantly lower in the buttocks than that in other sites （P<0.05）. The reported incidence of AEFI was significantly higher in booster immunization than that in basic immunization （P<0.05）. After inoculation at different sites， the main clinical symptoms of AEFI were local redness and swelling. There were significant differences in the incidence of local redness and swelling， local induration， pruritus and other symptoms （lethargy， abnormal crying， etc.） （P<0.05）. There were significant differences in the severity of local redness and swelling in different sites （P<0.05）. The degree of redness and swelling in the anterolateral thigh was lower than that in other sites （P<0.05）. The local strong reaction of swelling （>5.0 cm） in the deltoid muscle of the upper arm was significantly higher than that in the buttocks （P<0.05）. ConclusionThe DPT vaccine is safe in different parts of the body and is worth popularizing.

Inflammation of the Gums

@#An 18-year-old woman presented to the clinic with painless bleeding of her gums upon brushing her teeth. The bleeding stopped spontaneously, and there was no other bleeding tendency. On further questioning, the patient had irregular menses and was taking the oral contraceptive pills (OCP) Diane-35ED® to regulate her menses. She had been on this medication for four months. She was not on any other medication and had no chronic illness.

Dietary supplementation with turmeric polyherbal formulation decreases facial redness: a randomized double-blind controlled pilot study / 中西医结合学报

BACKGROUND@#Facial redness is multifactorial in nature and may be a sign of many different conditions, including rosacea, photo damage and flushing. Herbal medicines have been used for thousands of years to treat a variety of dermatological conditions. Turmeric (Curcuma longa) and its constituents have been shown to mediate dilation and constriction of peripheral arterioles and have demonstrated anti-oxidant, anti-inflammatory and wound-healing properties.@*OBJECTIVE@#To investigate the effects of turmeric and turmeric-containing polyherbal combination tablets versus placebo on facial redness.@*DESIGN, SETTING, PARTICIPANTS, AND INTERVENTIONS@#This was a prospective, double-blind, randomized pilot study. Thirty-three healthy participants were recruited from the dermatology clinic at the University of California, Davis and nearby community from 2016 to 2017. Thirty participants were enrolled, and 28 participants completed the study. The enrolled participants were randomized to receive one of three interventions (placebo, turmeric or polyherbal combination tablets) and were told to take the intervention tablets by mouth twice daily for 4 weeks. Facial redness was assessed at baseline and 4 weeks after intervention by clinical grading and by image-based analysis.@*MAIN OUTCOME MEASURES@#The primary outcome measure was image-based facial quantification of redness using a research camera and software analysis system. The investigators performed an intention-to-treat analysis by including all subjects who were enrolled in the trial and received any study intervention. Differences were considered statistically significant after accounting for multiple comparisons. Effect sizes for clinical grading were calculated with a Hedges' g where indicated.@*RESULTS@#Twenty-eight participants completed the study and there were no reported adverse events. Based on clinical grading, facial redness intensity and distribution down trended in the polyherbal combination group after 4 weeks (P = 0.1). Under photographic image analysis, the polyherbal combination group had a significant decrease in redness of 40% compared to baseline (P = 0.03). The placebo and turmeric groups had no statistically significant changes in image analysis-based facial redness.@*CONCLUSION@#Polyherbal combination tablet supplementation improved facial redness compared to the turmeric or placebo. Overall, our findings suggested further investigations into the effects of turmeric and polyherbal formulations in skin conditions associated with facial redness would be warranted.@*TRIAL REGISTRATION@#ClinicalTrials.gov identifier: NCT03065504.

A Local Clinic Experience of Facial Redness in Koreans / 대한피부과학회지

No abstract available.

Both switching from a winged needle to a small plastic intravenous catheter and adding dexamethasone to continuous subcutaneous infusion (CSCI) successfully treated inflammatory skin changes caused by CSCI

<b>Purpose</b>: The continuous subcutaneous infusion (CSCI) is one of the most popular methods to reduce cancer pain. Inflammatory skin changes such as redness and induration are sometimes observed around the infusion site of the skin. Although dexamethasone is empirically added to a CSCI regimen to reduce such skin changes, little evidence on this practice has been available. We aimed to demonstrate the effectiveness of the CSCI protocol that we have been using for the treatment of skin changes. <b>Methods</b>: We prospectively observed the incidence of skin changes. When redness or induration at the injected site appeared, a winged needle was switched to a plastic intravenous catheter. When the redness or induration did not resolve with this needle change, dexamethasone was added to CSCI. <b>Result</b>: Sixty-six patients with cancer pain who underwent CSCI using a winged needle were enrolled in this study. The CSCI needles were switched from a winged needle to a plastic intravenous catheter in 20 out of 66 patients who revealed redness at a size of greater than 10 mm in diameter during CSCI. After this needle switch, the skin changes resolved in 15 out of 20 patients. Among the five patients who did not respond to the needle change, the skin changes resolved in three patients by dexamethasone (0.5∼1 mg/day) added to CSCI. <b>Conclusion</b>: These findings suggest that both switching from a winged needle to a small plastic intravenous catheter and adding dexamethasone to a CSCI regimen are effective in the treatment of inflammatory skin changes caused by CSCI.

Distribuição espacial da granulometria, cor e carbono orgânico do solo ao longo de um transecto em microbacias na Amazônia meridional / Spatial distribution of soil texture, color and soil organic carbon across a headwater transect in the southern Amazon

O objetivo deste estudo foi determinar, em nível de detalhe, a distribuição e a variabilidade espacial da argila, do índice de avermelhamento e do carbono orgânico do solo, ao longo de transecto que cruza classes pedológicas distintas dentro de quatro microbacias, sob floresta tropical em Juruena (MT). Para isso, foram selecionados 34 pontos e coletadas amostras de solo nas profundidades de 0 a 20 cm e 40 a 60 cm. Os dados foram analisados por estatística descritiva e geoestatística. As maiores variabilidades espaciais ocorreram dentro da classe do Latossolo Vermelho-Amarelo Distrófico. Estes ocorrem nas elevações superiores a 280 m, enquanto os Plintossolos e Argissolos (com caráter plíntico) têm ocorrência restrita às áreas com altimetrias menores. Ao longo do transecto há maior variabilidade nos atributos índice de avermelhamento e argila; as áreas com piores condições de drenagens apresentaram menor variação espacial e menores índice de avermelhamento, isto é, maior homogeneidade da cor dos horizontes diagnósticos.

The study was conducted in forested headwater catchments near Juruena, Mato Grosso with the objective of determining the spatial distribution of soil physical characteristics including clay content, redness ratio, and soil organic carbon along a transect that encompassed distinct soil classes. Soil samples from 0-20 cm and 40-60 cm depths were collected from 34 points. Variables were analyzed using descriptive statistics and geostatistics. The parameters analyzed by ordinary kriging demonstrated that the highest spatial variability occurred within the soil class Typic Kandiustox. In the study area, Plinthustults and Ultisols (with plinthic characteristics) were only found to occur in landscape positions less than 280 m above sea level; Oxisols were found exclusively above 280 m.a.s.l. The redness ratio and clay content were the soil parameters with the highest spatial variability across the transect. Poorly drained areas (demonstrated by lower values of redness ratio) demonstrated the lowest degree of spatial variability, and correspondingly, the highest consistency of color within the diagnostic horizons.

The Therapeutic Effect of Unsei-in on Facial Redness (Inflammatory Congestion) in Atopic Dermatitis. A Clinical Study of 20 Cases / 日本東洋医学雑誌

The effectiveness of Kampo therapy for facial redness was studied in 20 cases of atopic dermatitis, using the Kampo extract Unsei-in (EK-57, etc.), which is known to have antiinflammatory and anti-allergic activities. Unsei-in was used without other Kampo extracts in 10 cases. Of these, marked improvement was observed in one case (10%) and improvement in two cases (20%), all of which improved within two weeks. Five cases did not respond to therapy, and the redness worsened in two cases. In ten other cases Unsei-in was used in conjunction with other Kampo extracts. Of these, improvement was observed in three cases (30%). Adverse reactions such as redness over the entire body (one case; 5%) and gastric pain (one case; 5%) were also observed. Despite these reactions, Unsei-in was shown to be useful in the treatment of facial redness associated with atopic dermititis.

Correlation of Endoscopic Redness with Histological Findings in Superficial Gastritis / 대한소화기내시경학회지

Superficial gastritis has been classified as a type of chronic gastritis, since a report of Schindler in GASTRLTIS, 1947. Howev~er, Benedict reported that superficial gastritis is only acute gastritis or shows normal mucosa histologically. The com mon endopical findings of chronic superficial gastritis were adherent mucus, edema, redness. The common redness which were encounterd are patchy redness and comb-like redness(Kammrotung). We studied the relationship between the redness of superficial gastritis and acute inflammatory changes histologically. Each case of superfieial gastritis was biopsied to redening and non-redening mucosa respectively. We collected 24 cases with 48 biopsy specimens. The results are as follows: Acute inflammatory changes were found only one case in redness and none in non-redness groups. There was no difference in acute inflammatory changes in two groups. The degree of mucosal atrophy were 62.5%, 66.7% in normal mucosa, 12.5%, 16.7~% in mild atrophy, 25%, 12.5% in moderate atrophy, 0%, 4.l% in severe atrophy with respect to redness and non-redness mucosa respectively. There was no difference in degree of mucosal atrophy in two groups. Mucosal atrophies were higher in older ages above 41 years old than below 40 and with increasing age, there was increasing tendency of mucosal atrophy. In conclusion, There was no relationships between mucosal redness and acute in flammatory changes histologically and also between mucosal redness and degree of atrophy.