Effect of Selenium-yeast on Cognitive Performance on Pregnant Dams Exposed to Noise Stress

A total of twelve pregnant Wistar rats were used, and randomly divided into three groups (n=4). Group A (negative control), not exposed to noise stress), group B (1mL/kg of distilled water + 4h /15 days noise stress), group C (0.04 mg/kg) of selenium-yeast + 4 h/15 days noise stress). On day 18 and 19 of gestation cognitive tests were conducted using Y-maze and Novel Object Recognition Test. A significant increase (P ? 0.05) was observed in the percentage alternation and discrimination index in group A compared with group B. However, the percentage alternation and DI were significantly (P ? 0.05) decreased in group C compared with group B. In conclusion, noise stress induces cognitive deficit, this deficit can be mitigated with the administration of selenium-yeast.

Effect of selenium yeast combined with vitamin D on thyroid hormone levels and cell apoptosis in Hashimoto′s thyroiditis rat model / 中华内分泌代谢杂志

Objective:To explore the effects of selenium yeast combined with vitamin D on thyroid hormone levels and cell apoptosis in Hashimoto′s thyroiditis rat model.Methods:Fifty-five SD rats were divided into control group( n=10) and model group( n=45). Five rats died during the modeling process, and the remaining were divided into model, selenium yeast, vitamin D, and combination therapy groups, with 10 rats in each group. Blood levels of thyroglobulin antibody(TGAb), thyroid peroxidase antibody(TPOAb), thyroid stimulating hormone(TSH), free triiodothyronine(FT 3), free thyroxine(FT 4), tumor necrosis factor α(TNF-α), interleukin(IL)-6, IL-10, IL-17, IL-23, selenium, and vitamin D3 were detected. HE and TUNEL staining were used to observe thyroid tissue morphology and cell apoptosis. Toll-like receptor(TLR)2, TLR4, myeloid differentiation protein 88(MyD88), NF-κB mRNA and protein expressions in thyroid tissue were detected by real-time PCR and Western blotting. Results:Thyroid cells were destroyed and the number of apoptotic cells was increased in model group compared with control group( P<0.05), along with increased levels of TGAb, TPOAb, TSH, TNF-α, IL-6, IL-17, and IL-23 as well as TLR2, TLR4, MyD88, NF-κB mRNA and protein expressions( P<0.05), and decreased FT 3, FT 4, IL-10, selenium, and vitamin D 3 levels( P<0.05). Thyroid cells were relatively normal and the number of apoptotic cells were reduced in the three treatment groups compared with model group( P<0.05), while TGAb, TPOAb, TSH, TNF-α, IL-6, IL-17, IL-23, TLR2, TLR4, MyD88, NF-κB levels were decreased( P<0.05), and FT 3, FT 4, IL-10, selenium, and vitamin D 3 levels were increased( P<0.05), showing the best effect in combination therapy group( P<0.05). Conclusion:Selenium yeast combined with vitamin D attenuates thyroid cell apoptosis, reduces autoimmune damage, and protects thyroid function via inhibiting TLRs/MyD88/NF-κB pathway.

Clinical observation of L-Thyroxine combined with selenium yeast in treating lymphocytic thyroiditis / 中国生化药物杂志

Objective To analyze the clinical effect of L-thyroxine combined with selenium yeast in patients with lymphocytic thyroiditis.Methods The clinical data of 96 patients with lymphocytic thyroiditis from March 2015 to September 2016 was analyzed retrospectively.The cases were divided into study group(48 cases)and control group(48 cases)according to double-blind method.The control group were treated with levothyroxine and the study group were treated with levothyroxine combined with selenium yeast.Free tetraiodothyronine(FT4),free triiodothyronine(FT3),thyrotropin(TSH),thyroglobulin antibody(TGAb),serum thyroid peroxidase antibody(TGAb)and serum thyroid peroxidase(TPOAb),the level of peripheral blood T cell subsets and the total effective rate between the two groups were compared.Results After treatment,the levels of FT4,FT3,TSH,TGAb and TPOAb in the two groups were significantly better than those before treatment(P<0.05).FT4,FT3,TSH,TGAb,TPOAb levels in the study group were significantly better than that in the control group(P<0.05).Compared with the control group,the T lymphocyte subsets of the study group after treatment were significantly better(P<0.05).Compared with the control group,the total effective rate of the study group was significantly higher(P<0.05).Conclusion The effect of L-thyroxine combined with selenium yeast in the treatment of lymphocytic thyroiditis patients is very significant.The treatment method is worthy of promotion in the clinical treatment.

DESEMPEÑO PRODUCTIVO, COMPOSICIÓN Y BIODISPONIBILIDAD RELATIVA DE SELENIO EN TILAPIA NILÓTICA -Oreochromis niloticus- SUPLEMENTADA CON SELENIO ORGÁNICO E INORGÁNICO / PRODUCTIVE PERFORMANCE, COMPOSITION AND RELATIVE SELENIUM BIOAVAILABILITY IN NILE TILAPIA -Oreochromis niloticus- SUPPLEMENTED WITH ORGANIC AND INORGANIC SELENIUM

Se evaluó el desempeño productivo, la composición corporal y la biodisponibilidad relativa de selenio en tilapia nilótica (Oreochromis niloticus) suplementada con selenio dietario. Una dieta basal fue suplementada con selenio en forma de selenito de sodio o seleno-levadura en niveles crecientes de suplementación (0.00, 0.10, 0.20, 0.40, 0.80 y 1.60 mg/kg de dieta). Un total de 336 individuos de tilapia nilótica, con un peso inicial de 13.41±0.12 g, fueron distribuidos de forma aleatoria en 48 acuarios de vidrio (80 l, 4 réplicas, 7 peces por acuario). No se detectó selenio en el agua de abastecimiento. Los peces fueron alimentados hasta saciedad aparente 3 veces al día por un período de 9 semanas. El desempeño productivo de la tilapia nilótica no se vio afectado (P>0.05) por la suplementación con selenio dietario. El selenio corporal se incrementó de forma lineal (P<0.05) con la suplementación de selenio orgánico e inorgánico. La composición corporal de selenio fue menor (P<0.05) en los peces suplementados con selenito de sodio (1.67±0.14 mg/kg) en comparación con la seleno-levadura (1.95±0.21 mg/kg). A partir de la relación entre pendientes se estimó que la biodisponibilidad relativa de la seleno-levadura para la composición de selenio corporal fue de 155.72±0,10%, con relación al selenito de sodio (fijada en 100%). De acuerdo con los resultados, la concentración basal de selenio dietario (0.21 mg/kg) no limitó el desempeño productivo de tilapia nilótica. La suplementación con selenio orgánico (seleno-levadura) e inorgánico (selenito de sodio) entre 0.10 y 1.60 mg/kg no afectó el desempeño productivo de la tilapia nilótica.

The aim of this study was to evaluate the productive performance, whole body selenium retention and relative selenium bioavailability in Nile tilapia (Oreochromis niloticus). A practical basal diet was supplemented with either sodium selenite or seleno-yeast at tilapia fish (n=336) with an initial weight of 13.41±0.12 g were randomly distributed into forty-eight glass aquaria (80 l, 4 replicates, 7 fish per aquarium). There was no detectable selenium in supply water. Fish were fed the experimental diets to apparent satiation three times daily for nine weeks. Selenium supplementation did not affect the productive performance of Nile tilapia (P>0.05). Total whole body selenium increase linearly in response to dietary selenium supplementation (P<0.05). Fish fed sodium selenite had lower (P<0.05) whole body selenium (1.67±0.14 mg/kg) compared to fish fed seleno-yeast (1.95±0.21 mg/kg). Based on the slope-ratio assay for whole body selenium, the relative bioavailability of seleno-yeast was 155.72%±0.10 compared to sodium selenite (set at 100%). According to results the basal selenium content in expegraded selenium levels (0.0, 0.10, 0.20, 0.40, 0.80 and 1.60 mg/kg). Reversed Nile rimental diets (0.21 mg/kg) did not limit the productive performance of Nile tilapia. Supplementation of inorganic and organic selenium (0.10-1.60 mg/kg) did not affect the productive performance of Nile tilapia.