Skipping breakfast is associated with being overweight among Brazilian adolescents

Objective: To evaluate the association between skipping breakfast and overweight among Brazilian adolescents. Methods: A total of 16,556 Brazilian students (aged 11-19 years) who participated in the National School Health Survey in 2015 were evaluated. The omission of breakfast (consumption frequency <5 days/week) was determined using the question, "Do you usually have breakfast"? The participants' weight and height were measured, and excess weight was classified according to the body mass index for sex and age. The covariates analyzed were sociodemographic and economic characteristics (sex, age group, socioeconomic status, skin color, maternal schooling, paid work, and living with parents); variables related to school (administrative dependence, study shift, and presence of a canteen); lifestyle (physical activity, alcohol consumption, smoking, sedentary behavior, consumption of industrialized foods, meals with parents, and school meals); and self-perception of body image. The association between skipping breakfast and being overweight was analyzed using a Poisson regression model with adjustment for covariates. Results: The prevalence of skipping breakfast and being overweight were 33.8% and 25.2%, respectively. After adjustment, skipping breakfast was associated with being overweight (OR:1.02; 95% CI:1.01; 1.04). Conclusion: Skipping breakfast is associated with being overweight among Brazilian adolescents. Thus, encouraging regular consumption of meals should be part of health promotion and healthy eating actions aimed at preventing diseases and chronic noncommunicable diseases.

Objetivo: Evaluar la asociación entre la omisión del desayuno y el sobrepeso entre adolescentes brasileños. Métodos: Fueron evaluados 16.556 estudiantes brasileños (de 11 a 19 años) que participaron en la Encuesta Nacional de Salud Escolar en 2015. La omisión del desayuno (frecuencia de consumo < 5 días/semana) se determinó mediante la pregunta "¿Desayuna habitualmente"? Se midió el peso y la talla de los participantes, y se clasificó el exceso de peso según el índice de masa corporal para el sexo y la edad. Las covariables analizadas fueron características sociodemográficas y económicas (sexo, grupo de edad, nivel socioeconómico, color de piel, escolaridad materna, trabajo remunerado y convivencia con los padres); variables relacionadas con la escuela (dependencia administrativa, turno de estudio y presencia de comedor); estilo de vida (actividad física, consumo de alcohol, tabaquismo, sedentarismo, consumo de alimentos procesados, comidas con los padres y alimentación escolar); y autopercepción de la imagen corporal. La asociación entre saltarse el desayuno y tener sobrepeso se analizó mediante un modelo de regresión de Poisson con ajuste por covariables. Resultados: La prevalencia de saltarse el desayuno y tener sobrepeso fue de 33,8% y 25,2%, respectivamente. Después del ajuste, saltarse el desayuno se asoció con sobrepeso (OR: 1,02; IC 95 %: 1,01; 1,04). Conclusión: Saltarse el desayuno está asociado con el sobrepeso entre los adolescentes brasileños. Por lo tanto, fomentar el consumo regular de comidas debe ser parte de las acciones de promoción de la salud y alimentación saludable dirigidas a la prevención de enfermedades y enfermedades crónicas no transmisibles.

Treatment status of non-small cell lung cancer with METexon14 skipping mutation / 国际肿瘤学杂志

MET exon14 (METex14) skipping mutation is an independent driver gene in non-small cell lung cancer (NSCLC) . About 3%-4% of NSCLC patients carry METex14 skipping mutation. These patients have poor prognoses and poor responses to traditional chemotherapy and immunotherapy. Highly selective MET inhibitors such as capmatinib, tepotinib, savolitinib have shown good efficacy and safety data in clinical trials, which bring new treatment options for patients with METex14 skipping mutations.

Aurora A Kinase Plays a Key Role in Mitosis Skip during Senescence Induced by Ionizing Radiation / 生物医学与环境科学（英文）

OBJECTIVE@#To investigate the fate and underlying mechanisms of G2 phase arrest in cancer cells elicited by ionizing radiation (IR).@*METHODS@#Human melanoma A375 and 92-1 cells were treated with X-rays radiation or Aurora A inhibitor MLN8237 (MLN) and/or p21 depletion by small interfering RNA (siRNA). Cell cycle distribution was determined using flow cytometry and a fluorescent ubiquitin-based cell cycle indicator (FUCCI) system combined with histone H3 phosphorylation at Ser10 (pS10 H3) detection. Senescence was assessed using senescence-associated-β-galactosidase (SA-β-Gal), Ki67, and γH2AX staining. Protein expression levels were determined using western blotting.@*RESULTS@#Tumor cells suffered severe DNA damage and underwent G2 arrest after IR treatment. The damaged cells did not successfully enter M phase nor were they stably blocked at G2 phase but underwent mitotic skipping and entered G1 phase as tetraploid cells, ultimately leading to senescence in G1. During this process, the p53/p21 pathway is hyperactivated. Accompanying p21 accumulation, Aurora A kinase levels declined sharply. MLN treatment confirmed that Aurora A kinase activity is essential for mitosis skipping and senescence induction.@*CONCLUSION@#Persistent p21 activation during IR-induced G2 phase blockade drives Aurora A kinase degradation, leading to senescence via mitotic skipping.

Assessment of skipping breakfast at home among adolescent school students in Badia Region, Jordan

@#Introduction: Healthy meals play an essential role in the healthy physical and mental development of adolescents. Breakfast at home is associated with improved nutritional choices, and skipping breakfast is detrimental. This study assessed prevalence of skipping breakfast at home among adolescent students in the Badia Region of Jordan, identifying the reasons and characteristics associated with such behavioural choice. Methods: A cross-sectional survey among adolescent students (aged 13-16 years, in 8th-9th grades) from six public schools in Badia Region, Mafraq Governorate, Jordan, was conducted through self-administered questionnaire from February to March 2022. Results: Results showed that 68.1% of 552 student participants regularly skipped breakfast at home (72.4% boys vs. 61.3% girls; p=0.007). Among those who regularly skipped breakfast, three main rationales for this choice were not feeling hungry (5.3%), lack of time (2.7%), and lack of appetite (3.5%). Conclusion: The prevalence of skipping breakfast at home among adolescents in Badia Region was high for various reasons, including lack of time, not feeling hungry, seeking to manage weight, and insufficient knowledge on the importance of healthy breakfast. Therefore, understanding the reasons and factors that contribute towards breakfast skipping may help in solving the problem, underscoring that positive beliefs should be reinforced in schools, with parents encouraging adolescents to eat healthy breakfast.

Expert Consensus on Targeted Therapy of NSCLC with MET Exon 14 Skipping Mutation / 中国肺癌杂志

The mesenchymal-epithelial transition factor (MET) exon 14 skipping mutation is mainly caused by the loss of c-Cbl tyrosine binding site. This mutation could result in a decrease in the degradation rate of proteasome-mediated MET proteins, trigger continuous activation of downstream pathways, and ultimately lead to tumorigenesis. The incidence of MET exon 14 skipping mutation in patients with non-small cell lung cancer (NSCLC) is 0.9% to 4.0%. Patients with advanced NSCLC are recommended to test MET exon 14 skipping mutations who may benefit from MET inhibitors-targeted therapy. MET inhibitors have a high objective response rate and good safety profiles, which could prolong the survival of NSCLC patients with MET exon 14 skipping mutations. The Lung Cancer Specialty Committee of Chinese Elderly Health Care Association organized multidisciplinary experts to give suggestions on the important issues of clinical aspects for targeted therapy of MET exon 14 skipping mutation in NSCLC according to the clinical practice experiences and evidences based medicine. "Expert Consensus on Targeted Therapy of NSCLC with MET Exon 14 Skipping Mutation" is proposed, aiming to provide standardized guidances for the clinical practice of Chinese physicians.
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Skipping breakfast associated with socioeconomic and lifestyle factors in Brazilian adolescents / Omitir o café da manhã está associado a fatores socioeconômicos e de estilo de vida entre adolescentes brasileiros

Abstract The aim is to estimate the prevalence and evaluate the association of socioeconomic and lifestyle factors with skipping breakfast among Brazilian adolescent students. A cross-sectional study carried out with adolescent ninth-graders from Brazilian public and private schools participating in the 2015 National School Health Survey. The prevalence of skipping breakfast (less than five days/week) and its respective 95% confidence intervals were estimated and stratified by gender according to demographic, socioeconomic, and lifestyle factors, self-perceived body image, and attitudes towards weight. A three-block hierarchical Poisson regression, considering the complex sample design. The prevalence of skipping breakfast was 35.6%, higher among girls than boys. In both genders, skipping breakfast was positively associated with the highest socioeconomic level, morning school shift, paid work, regular consumption of alcoholic beverages, living only with the mother, the father or neither, the irregular consumption of school food and meals with parents, considering oneself too fat/fat and trying to lose weight. In general, skipping breakfast was associated with socioeconomic factors and lifestyle behaviors harmful to health among adolescent students.

Resumo O objetivo é estimar a prevalência e avaliar a associação dos fatores socioeconômicos e de estilo de vida com a omissão do café da manhã entre adolescentes escolares brasileiros. Um estudo transversal realizado com adolescentes do 9º ano de escolas públicas e privadas brasileiras participantes da Pesquisa Nacional de Saúde do Escolar de 2015. A prevalência de omissão do café da manhã (menos de cinco dias/semana) e seus respectivos intervalos de confiança de 95% foram estimados e estratificados por sexo de acordo com fatores demográficos, socioeconômicos, estilo de vida, autopercepção da imagem corporal e atitudes em relação ao peso. Uma regressão de Poisson hierárquica de três blocos, considerando o desenho amostral complexo. A prevalência de pular o café da manhã foi de 35,6%, maior entre as meninas do que entre os meninos. Em ambos os sexos, omitir o café da manhã associou-se positivamente com maior nível socioeconômico, turno escolar matutino, trabalho remunerado, consumo regular de bebidas alcoólicas, morar apenas com a mãe, pai ou nenhum dos dois, consumo irregular de alimentação escolar e refeições com os pais, considerar-se muito gordo/gordo e tentar perder peso. Em geral, a omissão do café da manhã foi associada a fatores socioeconômicos e comportamentos de estilo de vida prejudiciais à saúde entre estudantes adolescentes.

MET14 exon skipping mutation and non-small cell lung cancer / 国际肿瘤学杂志

The molecular mechanism of the skipping mutation of MET14 exon (METex14) is mainly that the skipping of METex14 leads to the loss of the c-Cbl tyrosine binding site, which causes the proteasome-mediated degradation of MET protein to decrease, which continuously activates the MET signal, and finally leads to tumorigenesis. The incidence of METex14 skipping mutations in non-small cell lung cancer is 3%-4%. Drugs that act on skipping mutations of METex14 include crizotinib, capmatinib, tepotinib, savolitinib, and have a high objective remission rate and good safety. However, due to gene amplification, second site mutations, bypass activation and pathological type conversion, drug resistance after targeted drug therapy requires attention.

Association between breakfast dietary patterns and physical activity in Japanese fifth- and sixth-grade elementary school children / 体力科学

This study aimed to explore the association of breakfast (BF) dietary patterns with physical activity (PA) and fitness in elementary school children. This study enrolled 242 school children of 5th and 6th grade. BF dietary patterns were evaluated by questionnaires on whether the child consumes the following food categories: staple, main dish, side dish, soup, milk or dairy products, and fruit. Individual PA levels were categorized into high and low PA groups using a PA scale for children. The measured 8 assessments of physical fitness scores were converted to Z-scores normalized for sex, age and height as previously reported. High PA group had significantly higher scores in running and muscle strength as well as in the total score of physical fitness. The frequency of eating BF (with or without BF omission) and the level of PA were not significantly related in both sexes. However, in girl children, BF, including staple, main dish, side dish, and soup, was significantly more prevalent in high PA group than low PA group (55.9% vs. 32.1%; χ2 = 5.638, p = 0.018). A similar tendency was observed in girls who had BF, including staple, main dish, and side dish (49.0% vs. 31.1%; χ2 = 3.720, p = 0.054). No associations between dietary patterns and PA were observed in boys. The results suggested that the frequency of eating BF was not associated with PA levels, which was significantly related to physical fitness in Japanese 5th and 6th grade elementary school children. In contrast, the results indicated that a high-quality BF dietary pattern, such as a meal including staple, main dish, side dish, and soup, might be associated with a physically active girl child.

Skipping breakfast and physical fitness among school-aged adolescents

OBJECTIVES: This study explored the relationship between skipping breakfast and physical fitness in a group of school-aged adolescents in China. METHODS: This cross-sectional study from the Chinese National Surveillance on Students' Constitution and Health (CNSSCH) survey in Ningbo, China, used a standardized questionnaire to assess the frequency of breakfast consumption. Physical fitness was measured through standing long jump, 50-m sprint, 1,000 (or 800)-m run, and vital capacity tests. Multiple linear regression analysis was used to investigate the relationship between the frequency of breakfast consumption and physical fitness. RESULTS: Our study included a total of 1,849 school-aged adolescents (aged 15.53±1.80 years). Among boys, non-breakfast-skippers had good scores for 50-m sprints, 1,000-m run, and vital capacity tests when compared with breakfast skippers (all p<0.05). Among girls, non-breakfast-skippers had a good scores for the standing long jump test compared with breakfast skippers (p=0.003). The multiple linear regression model showed that not skipping breakfast was positively associated with vital capacity (β=-173.78, p=0.004) and inversely associated with 50-m sprint (β=-0.12, p=0.018) and 1,000-m run times (β=-8.08, p=0.001) in boys. CONCLUSION: The results of this cross-sectional study revealed that skipping breakfast might be associated with lower physical fitness in Chinese adolescents aged 13-18 years, especially boys. Breakfast consumption should be promoted among Chinese school-aged boys.

Financial problems associated with food insecurity among public university students in Peninsular Malaysia

@#Introduction: Food is a necessity for students. Yet, students’ food expenditure is anticipated to be restrained by their financial status. This cross-sectional study aims to determine the prevalence of food insecurity and its determinants among university students attending public universities in Peninsular Malaysia. Methods: Multistage random sampling was used to select respondents from public universities in Peninsular Malaysia. A total of 427 undergraduate students completed a selfadministered questionnaire at four randomly selected universities (Universiti Utara Malaysia, Universiti Kebangsaan Malaysia, Universiti Malaysia Pahang and Universiti Teknologi Malaysia). The questionnaire consisted of information concerning demographic and socioeconomic backgrounds, food security status, eating behaviour, financial literacy, and financial problem among university students. Frequency, chi-square, and logistic regression were used to analyse the variables. Results: Mean age of the respondents was 21.6 years, and 60.9% were found to be food insecure. Gender (χ2=5.415), origin (χ2=3.871), number of siblings (χ2=4.521), financial problem (χ2=42.364), and regular breakfast intake (χ2=5.654) were associated with food security status (p<0.05). Male respondents had 1.5 times (AOR=1.547, 95% CI: 1.006-2.380) the risk of having low food security status. Those with higher financial problems (AOR=3.575, 95% CI: 2.332-5.481) were 3.5 times more likely to be food insecure. Conclusion: The prevalence of food insecurity among public university students in Peninsular Malaysia was significantly high. Thus, intervention studies should focus on students with financial problems. Moreover, establishing a better system for an on campus food pantry or food bank is needed to counter the high prevalence of food insecurity among university students.

Association of dietary habits with obesity among school adolescents in Central India

Background: The growing prevalence of obesity among school adolescents is a major public health concern. It can be seen mostly as a result of modifiable risk factors like lack of required physical activity and rapid change in dietary habits among them.Methods: The present cross sectional descriptive study was done among adolescents studying in schools (government and private) of Bhopal city. School adolescents were classified as obese and non-obese as per the WHO criteria used for obesity in South East Asia Region (SEAR). Pre-tested, self-administered questionnaire was used to collect data which comprised of socio demographic information and various dietary habits like frequent consumption of fast & fried food, bakery products and little dietary behavior.Results: Out of total 6.6% obese school adolescents, majority of them consume fast foods (82%), fried foods (89%) and bakery products (79.5%) and all of these were positively associated with increased risk of obesity. Few eating behaviours like skipping breakfast, frequent snacking and eating outside were also found positively associated.Conclusions: There is definitely a major role of dietary habits for increased risk of obesity among school adolescents. So, it is the need of hour to create awareness among school adolescents regarding their dietary habits.

Evaluation of the meal variety with eating breakfast together as a family in Korean children: based on 2013 ~2015 Korean National Health and Nutrition Examination Survey / 한국영양학회지

PURPOSE: The aim of this study was to identify the nutritional status in Korean children eating breakfast together as a family or skipping breakfast from the 2013 ~ 2015 Korea National Health and Nutrition Examination Survey (KNHANES). METHODS: A total of 1,393 subjects (boys = 731, girls = 662), aged 6 ~ 11 years, were presented with a 24 hr-recall method, and classified according to their eating breakfast together as a family or skipping breakfast; and eating breakfast together as a family (EBF group; boys = 580, girls = 548), eating breakfast alone (EBA group; boys = 100, girls = 67), and skipping breakfast (SB group; boys = 51, girls = 47). RESULTS: In the boys, the SB group had a significantly lower carbohydrate (p = 0.0198) and vitamin C (p = 0.0219) density, and a higher fat (p = 0.0020) density than the EBF and EBA groups. In both boys and girls, the EBF and EBA groups showed a significantly larger number of dishes in breakfast than the SB group (p < 0.0001, respectively). In boys, the EBF group showed a significantly higher number of foods in breakfast than the EBA and SB groups (p < 0.0001). CONCLUSION: Children eating breakfast together as a family may be associated with a variety of food intake than children eating breakfast alone and skipping breakfast.

Meal skipping habits and nutritional status among Ghanaian students living in Korea / 한국영양학회지

PURPOSE: The consistent rise in the number of foreign students in Korea demands an accurate and detailed investigation into their dietary practices and nutritional status. For these international students, assimilation into new cultures can be stressful. The influence this process may have on dietary behaviors as well as overall health cannot be overlooked. METHODS: The researchers in this study sought to investigate the nutritional status and dietary practices of Ghanaian students studying in Korea. A total of 81 Ghanaian male students with an average age of 29.4 ± 4.0 years were sampled between May and June 2016. Investigations were carried out on the general characteristics of the participants, their daily food and nutrient intakes using a 24-h dietary recall method, meal skipping practices, and the nutritional quality of their diets based on their meal skipping habits. RESULTS: The study revealed that the daily nutrient intake of subjects did not fully meet the daily recommended nutrient intake (RNI) established by Ghanaian Ministry of Health and the World Health Organization (WHO) and Food and Agriculture Organization (FAO), particularly for energy, calcium, iron, zinc, and vitamin B2 requirements. The Nutrient Adequacy Ratio (NAR) for calcium was very low, posing a deficiency risk to the participants. Meal skipping practices among participants changed significantly after arriving in Korea. The study also compared the diet quality indicators (Nutrient Adequacy Ratio and Mean Adequacy Ratio) of those who skipped meals ≥ 7 times/week with those who skipped meals < 7 times/week. Participants who skipped meals ≥ 7 times/week were shown to have lower dietary intakes of vitamins B1 and B2 than those who skipped meals < 7 times/week. CONCLUSION: Ultimately, the study found that meal skipping among Ghanaian students was common, and their daily nutrient intakes did not meet the set dietary standards. Those who skipped meals ≥ 7 times/week had lower dietary intakes of vitamins B1 and B2 than those who skipped meals < 7 times/week. Based on our study findings, we recommend that nutrition education should be organized for the Ghanaian student community in Korea using our results as a template to draw up a nutrition program that is culturally appropriate.

Dietary and Lifestyle Habits and Dietary Behaviors According to Level of Smartphone Addiction in University Students in Kyungnam Province

The purpose of this study was performed to investigate dietary and lifestyle habits, dietary behaviors, and food frequency according to the level of smartphone addiction among 408 university students in Kyungnam province. Statistical analyses were performed using the SPSS software package. Based on using the Smartphone Addiction Poneness Scale, 28.4% were potential-risk smartphone users and while 13.2% were high-risk smartphone users. The levels of depression (P<0.05) and stress (P<0.05) and frequency of snacks (P<0.01) were higher in high-risk and potential-risk groups than in the normal group, and meal frequency was highest in the high-risk group (P<0.01). Percentages of using a smartphone at meal time (P<0.01) and snacking while using a smartphone (P<0.01) were higher in potential-risk and high-risk groups than in the normal group. Percentages of skipping meals (P<0.001) and slow eating speed (P<0.01) due to using a smartphone were higher in high-risk and potential-risk groups than in the normal group, and percentages of taste change (P<0.05) were higher in the high-risk group than in the potential-risk and normal groups. Percentages of exercise reduction (P<0.01), body weight increase (P<0.05), sleep disturbance (P<0.001), and increase in stress (P<0.01) due to using a smartphone were higher in the high-risk group than in the normal group. Scores of dietary behaviors avoiding salty food (P<0.01) and excessive drinking (P<0.001) were higher in the high-risk group than in the normal group. Scores for frequency of oil or nuts (P<0.05) and fatty meats (P<0.01) were highest in the high-risk group. Our results suggest that effective nutrition education programs are needed to solve unhealthy dietary and lifestyle habits from high-risk smartphone users in university students.

Factors Affecting the Frequency of Skipping Meals of Prime-Aged Mothers with Children : Data from the Fifth Korea National Health and Nutrition Examination Survey, 2010-2011 / 대한지역사회영양학회지

OBJECTIVES: This study was designed with the goal of understanding the factors affecting the frequency of skipping meals of prime-aged mothers with children as well as their nutritional status. METHODS: Utilizing data from the 2010-2011 Korea National Health and Nutrition Survey, the frequency of skipping meals of mothers aged between 30 to 49 years with children aged between 3 to 11 years during a two day period was statistically analyzed. The number of meals skipped calculated and categorized into skipping no meals, skipping one meal, skipping two meals or more. RESULTS: Compared to subjects who corresponded to mean nutrient adequacy ratio(MAR) of 4 quartile, subjects who corresponded to MAR of 2 quartile had 2.766 (95% CI: 1.552-4.931) probability of being in the 1 meal skippers group, while the probability of being in the more than 2 meals skippers group was 2.743(95% CI: 1.353-5.564). Also, compared to subjects who corresponded to MAR of 4 quartile, subjects who corresponded to MAR of 1 quartile had 3.471 (95% CI: 1.871-6.442) probability of being in the 1 meal skippers group, while the odds ratio for being in the more than 2 meals skippers group was 5.258(95% CI: 2.642-10.466). CONCLUSIONS: The results have the advantage of being generalized because the study selected subjects from probability sampling of the female population of Korea. The research results showed that the elements influencing skipping meals of prime-aged mothers with children were mean nutrient adequacy ratio and the number of nutrients, under estimated average requirement intake, and others. Therefore, to encourage dietary behaviors in the right direction, an integrated approach that considers the associated factors must be realized. Future studies are needed to understand how the frequency of skipping meals of mothers affects their children.

Life style Factors Influencing BMI of Females In Ha’il Region.

Background: Published health promoting or health risk behaviors data in a young population is sparse for Saudi Arabia. Identifying health risk factors early in life and promoting primary prevention interventions among the youth is of utmost importance to move in a healthier direction Objectives: The aim of this study is to identify the socio-economic factors influencing BMI in female students in University of Hail. Methodology: A cross sectional survey was carried out to evaluate dietary behaviors in a random sample of 200 adolescent students, from UOH female campus during the winter semester. Self administered questionnaire for dietary behaviors was used for survey by following anonymity and privacy. Results: This study was conducted to measure BMI and determine the socioeconomic factors affecting the relative weight of young adult females living in the city of Ha’il, Saudi Arabia. A total of 200 female subjects (mean ± SD: age: 19.76 ± 1.98 years and BMI: 23.47 ± 5.58 kg/m2) participated in the present survey. 28.5 % percent of study sample were either overweight or obese. Age wise distribution indicates overweight and obesity significantly increases with age. Breakfast is frequently skipped in overweight and obese subjects while frequency of snacking less among them. Findings of the current study also suggest habit of frequent snacking behavior inverse association with BMI. The current study findings have indicated no clear impact of physical activity on obesity prevalence.

Variation in Meal-skipping Rates of Korean Adolescents According to Socio-economic Status: Results of the Korea Youth Risk Behavior Web-based Survey / 예방의학회지

OBJECTIVES: To identify and evaluate the trend of meal-skipping rates among Korean adolescents with their contributing causes and the influence of household income level on meal skipping. METHODS: Using 2008, 2010, and 2012 data from the Korea Youth Risk Behavior Web-based Survey of 222 662 students, a cross-sectional study with subgroup analysis was performed. We calculated odds ratios for skipping each meal 5 or more times in a week by household socio-economic status using a multiple logistic regression model. The secular change in the meal-skipping rates by the students' family affluence scale was analyzed by comparing the meal-skipping students within each subgroup and odds ratios for the same event over time. RESULTS: Through 2008 to 2012, most of the meal-skipping rates generally showed a continuous increase or were almost unchanged in both sexes, except for breakfast skipping in several subgroups. Students in low-income households not living with both parents had the highest meal-skipping rates and odds ratios for frequent meal skipping. In a time-series subgroup analysis, the overall odds ratios for the same event increased during 2008 to 2012, with a slight reduction in the gap between low and higher income levels with regard to meal skipping during 2010 to 2012. CONCLUSIONS: Household socio-economic status and several other factors had a significant influence on Korean adolescent meal-skipping rates. Although the gap in eating behavior associated with household socio-economic differences is currently decreasing, further study and appropriate interventions are needed.

A Korean case of neurofibromatosis type 1 with an exonic splicing enhancer site mutation

Neurofibromatosis type 1 (NF1) is an autosomal dominant disease characterized by neurological, cutaneous, and ophthalmological manifestations. A 33-year-old woman with typical symptoms of NF1 visited Ajou University Hospital. Screening of the whole-messenger RNA region of NF1 at the complementary DNA level by polymerase chain reaction-direct sequencing confirmed the presence of an NF1 mutation at the genomic level. The mutation analysis revealed an in-frame skipping of exon 46 (c.6757_6858del) caused by a point mutation (c. 6792C>A) in exon 46. In this report, we have described the first Korean case of a proband with NF1 that carries an allele with an exon 46 deletion caused by an exonic splicing enhancer site mutation, leading to the skipping of the whole of exon 46 (c.6757_6858del).

Saltear una o más sesiones de diálisis aumenta significativamente la tasa de mortalidad: impacto de medir la no adherencia / Skipping one or more dialysis sessions significantly increases mortality rate: measuring the impact of non-adherence

Introducción: La no adherencia a la frecuencia prescripta de sesiones de diálisis se observa en rangos del 2% al 50% de los pacientes. El objetivo de este estudio fue evaluar el impacto de medir y detectar la no adherencia a la frecuencia dialítica prescripta y determinar la importancia de un enfoque multidisciplinario con el fin de mejorar la adherencia. Métodos: Estudio de cohorte longitudinal incluyendo a 8164 pacientes en HD de clínicas de Fresenius Medical Care Argentina, prevalentes en abril 2010, con más de 90 días de tratamiento y seguimiento a 3 años. Se evaluó por encuesta: salteo de al menos una sesión de diálisis en un mes o acortamiento de por lo menos 10 minutos de una sesión de diálisis en un mes, durante los 6 meses previos a la encuesta. Se evaluaron riesgos relativos de mortalidad entre grupos. Resultados: 648 pacientes (7.93%) salteaban sesiones de diálisis: 320 (3.92%) salteaban una sesión por mes y 328 (4.01%) salteaban más de una sesión por mes. Luego de 3 años de seguimiento, 349 pacientes (53.85%) permanecían activos en hemodiálisis y 299 estaban inactivos por diferentes motivos: 206 fallecidos (31.79%), 47 transferencias o pérdidas de seguimiento (7.25%), 36 trasplantados (5.55%), 8 cambios de modalidad a DP (1.23%) y 2 recuperaciones de la función renal (0.3%). Saltear una sesión de diálisis por mes aumentó significativamente el riesgo de mortali dad comparando ambos grupos (salteadores y no salteadores): RR = 2,65 (IC 95% 2.24 - 3.14). Saltear más de una sesión de diálisis también aumentó significativamente el riesgo de mortalidad comparado con los no salteadores: RR = 2.8 (IC 95% 2.39 - 3.28). Luego de 3 años de seguimiento, un 41,66% de los salteadores al inicio habían mejorado su adherencia a través de un programa multidisciplinario de mejora de calidad. Conclusión: La mortalidad global fue mayor entre aquellos pacientes salteadores de sesiones de diálisis. Una proporción considerable de pacientes salteadores al inicio modificaron su conducta a través de la implementación de un programa multidisciplinario de mejora de calidad.

Background: Non-adherence to the prescribed dialysis sessions frequency ranges from 2% to 50% of patients. The objective of this study was to evaluate the impact of detecting and measuring the non-adherence to the prescribed dialysis frequency and to determine the importance of a multidisciplinary approach with the aim of improving adherence. Materials: longitudinal cohort study including 8,164 prevalent hemodialysis patients in April 2010, with more than 90 days of treatment, in Fresenius Medical Care Argentina units that were monitored for 3 years. The survey evaluated: interruption of at least one dialysis session in a month or reduction at least 10 minutes of a dialysis session in a month, during 6 months prior to the survey. Relative mortality risks were evaluated among groups. Results: 648 patients (7.9%) interrupted dialysis sessions: 320 (3.9%) interrupted one session per month and 328 (4.01%) interrupted more than one session per month. After 3 years monitoring, 349 patients (53.8 %) remained active in hemodialysis and 299 were inactive due to different reasons: 206 deceased (31.8 %), 47 transfers or monitoring losses (7.25 %), 36 transplanted (5.55 %), 8 changes to PD modality (1.2%) and 2 recovered their kidney function (0.3 %).Interrupting one session per month significantly increased the mortality risk comparing both groups (interrupters and non-interrupters): RR 2.65 (IC 95% 2.24 - 3.14). Interrupting more than one dialysis session also increased significantly mortality risk comparing to the non-interrupters: RR 2.8 (IC 95% 2.39 - 3.28). After 3 years monitoring, 41.6 % of interrupters at the beginning had improved their adherence through a multidisciplinary program of quality improvement. Conclusion: Global mortality was greater among patients who interrupted dialysis sessions. A considerable proportion of interrupter patients at the beginning modified their behavior through the implementation of a multidisciplinary program of quality improvement.

Skipping breakfast is correlated with obesity / Journal of Rural Medicine

<i>Objectives:</i> Despite the fact that the total energy intake of Japanese people has decreased, the percentage of obese people has increased.This suggests that the timing of meals is related to obesity. <br>The purpose of the study was to investigate the relationship between the timing of meals and obesity, based on analyses of physical measurements, serum biochemical markers, nutrient intake, and lifestyle factors in the context of Chrononutrition.<br><i>Participants and Methods:</i> We analyzed data derived from 766 residents of Toon City (286 males and 480 females) aged 30 to 79 years who underwent detailed medical examinations between 2011 and 2013. These medical examinations included. (1) physical measurements (waist circumference, blood pressure, etc.); (2) serum biochemical markers (total cholesterol, etc.); (3) a detailed questionnaire concerning lifestyle factors such as family structure and daily habits (22 issues), exercise and eating habits (28 issues), alcohol intake and smoking habits; (4) a food frequency questionnaire based on food groups (FFQg);and (5) a questionnaire concerning the times at which meals and snacks are consumed.<br><i>Results:</i> The values for body mass index (BMI) and waist circumference were higher for participants who ate dinner less than three hours before bedtime (<3-h group) than those who ate more than three hours before bedtime (>3-h group). The Chi-square test showed that there was a significant difference in eating habits, e.g., eating snacks, eating snacks at night, having dinner after 8 p.m., and having dinner after 9 p.m., between the <3-h group and the >3-h group. <br>Multiple linear regression analysis showed that skipping breakfast significantly influenced both waist circumference (β = 5.271) and BMI (β = 1.440) and that eating dinner <3-h before going to bed only influenced BMI (β = 0.581).<br><i>Conclusion:</i> Skipping breakfast had a greater influence on both waist circumference and BMI than eating dinner <3-h before going to bed.