Synthesis and antitumor activity of some hydrazinoacridine hydrazinoacridonanil and 9-oxo-9, 10-dihydroacridin-4-carboxazide derivatives

Six series of acridine derivatives of anticipated antitumor activity have been designed and synthesized. The first comprised 9-[4 sulfamoylphenyl] hydrazinoacridine. The second consisted of 9-[4-sulfamoylphenyl] hydrazinoacridonanil. The third included N- substituted 9-[4 sulfamoylphenyl] hydrazinoacridine-4-yl [N-[4-sulfamoylphenyl]] carboxamide. While the fourth and the fifth included N substituted 9-[4-sulfamoylphenyl]] hydrazinoacridin-4-yl[N- sulfamoylphenyl]] carboxazide derivatives; and the sixth included 9-oxo-9, 10-dihydroacridin-4-yl [N-[4-sulfamoylphenyl]] carboxazide derivatives. The rationale behind the synthesis of these compounds, their methods of synthesis as well as the antitumor activities have been presented

Synthesis of some substituted 9-anilinoacridines and 4-anilinoquinolines of possible antitumor activity

3-amino-4-methoxybenzoie acid methyl ester and 3-amino- 4-methoxy-6- methane sulphonamidobenzoic acid methyl ester were condensed with 4, 7-dichloroquinoline, 4-chloroquinaldine, 9-chloroacridine and 2-methoxy-6,9-dichloro acridine. The anilide esters obtained were reduced to the corresponding alcohols from which the N-methylcarbamate derivatives were prepared as possible antitumour agents