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1.
Indian J Exp Biol ; 2001 Aug; 39(8): 802-6
Artigo em Inglês | IMSEAR | ID: sea-61036

RESUMO

Organophosphate (OP) pesticides, monocrotophos (MCP), dichlorvos (DDVP) and phosphamidon significantly inhibit both MAO-A and MAO-B activities in rat brain mitochondria. The inhibition of MAO-A by MCP is reversible whereas the inhibition by DDVP and phosphamidon is irreversible. MAO-B is inhibited irreversibly by all these organophosphates suggesting that the mechanism of action of OP pesticides is through phosphorylation of serine residue present in active centre of MAO.


Assuntos
Animais , Benzilaminas/metabolismo , Encéfalo/enzimologia , Inseticidas/metabolismo , Masculino , Mitocôndrias/enzimologia , Monoaminoxidase/metabolismo , Compostos Organofosforados , Oxirredução , Ratos , Ratos Wistar , Serotonina/metabolismo
2.
Hindustan Antibiot Bull ; 1989 Feb-May; 31(1-2): 25-8
Artigo em Inglês | IMSEAR | ID: sea-2593

RESUMO

Binding of penicillin amidase from E. coli 436 to aniline-, benzylamine- and phenylethylamine-Sepharose was studied. Binding of the enzyme to aniline-Sepharose was exclusively due to hydrophobic interactions. Benzylamine-Sepharose binds the enzyme due to affinity interactions in the absence of ammonium sulphate and due to hydrophobic interactions in the presence of ammonium sulphate. A conformational change in the penicillin amidase molecule due to ammonium sulphate there by exposing the side chain binding site as a hydrophobic core is suggested.


Assuntos
Amidoidrolases/metabolismo , Compostos de Anilina/metabolismo , Benzilaminas/metabolismo , Cromatografia de Afinidade , Penicilina Amidase/metabolismo , Fenetilaminas/metabolismo
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