Two colorimetric methods for the assay of six nonsteroidal anti-inflammatory drugs in their pure and dosage forms

This paper described two new colorimetric methods for estimation of six nonsteroidal anti-inflammatory drugs; namely, piroxicam, tenoxicam, mefenamic acid, flufenamic acid, ibuprofen and ketoprofen in their pure forms and pharmaceutical preparations. The first method depends on scanning the azodyes resulting from the reaction of piroxicam and tenoxicam with diazonium salts of benzocaine, p-amino-N- methylbenzamide and sulfadiazine. The second procedure is based on colorimetric determination of the blue colored complexes yielded from the reaction of methylene blue with drugs under investigation. The different conditions for the proposed methods were studied. The methods have been applied for the analysis of pharmaceutical preparations containing these drugs and the results obtained were compared with those of pharmacopoeial or published methods. The methods are simple, precise and reproducible

Proton magnetic resonance assay of ketoprofen in capsules

A simple, rapid and efficient new quantitative PMR method has been developed for the determination of ketoprofen and its dosage form [capsules]. The method is based on comparison of the integral of the methyl signal or the aromatic protons signal of ketoprofen with that of the sharp singlet of maleic acid [at 6.5 ppm] used as internal st and ard. The proposed method gave accurate, precise and reproducible results, which were comparable with those obtained by the official titrimetric BP 1980 method