RESUMO
Data from 31 children, 23 females (74.2%) and eight males (25.8%) with precocious puberty were analysed. They included 19 cases with central precocious puberty, 5 with premature thelarche, 5 with premature adrenarche and 1 each with adrenal adenoma and virilizing hepatoblastoma. Their clinical and hormonal profile and the treatment outcome are briefly discussed.
Assuntos
Antagonistas de Androgênios/uso terapêutico , Compostos de Anilina/uso terapêutico , Criança , Pré-Escolar , Ciproterona/análogos & derivados , Acetato de Ciproterona , Feminino , Humanos , Imunossupressores/uso terapêutico , Lactente , Masculino , Medroxiprogesterona/análogos & derivados , Acetato de Medroxiprogesterona , Puberdade Precoce/diagnósticoRESUMO
The animals were treated with cyproterone acetate (1 mg/100 g body weight) for 60 days after which the testicular tissue was studied at the ultrastructural level to determine the stage at which the effect took place and to study the magnitude of the effect. The testis showed changes in Sertoli cells, Leydig cells, germ cells and in the spermatids. To correlate these changes, important marker enzymes and other biochemical parameters essential for spermatogenesis were studied after 30 days and 60 days of the treatment. They registered a decrease in their levels as compared with the controls.
Assuntos
Antagonistas de Androgênios/farmacologia , Animais , Ciproterona/análogos & derivados , Acetato de Ciproterona , Células Intersticiais do Testículo/efeitos dos fármacos , Masculino , Microscopia Eletrônica , Ratos , Ratos Endogâmicos , Células de Sertoli/efeitos dos fármacos , Testículo/efeitos dos fármacosRESUMO
Effect of three antiandrogens: cyproterone acetate (5 mg/day, sc), flutamide (5 mg/day, sc) and STS-557 (5 mg/day, po) and an estrogen, estradiol dipropionate (5 micrograms/day, sc) on some key enzymes of carbohydrate metabolism was investigated in adult rat epididymis and ventral prostate. Antiandrogens were administered for 21 days and estrogen for 14 days. All of them caused a significant decrease in the weight of epididymis, seminal vesicles and ventral prostate. A significant decrease in the specific activities of enzymes (hexokinase, phosphofructokinase, aldolase, glyceraldehyde phosphate dehydrogenase, pyruvate kinase, glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase) occurred only in the organs of estrogen treated rats; activities of some of the enzymes were lowered also in the prostate of STS-557 treated rats. Flutamide and cyproterone acetate were ineffective in this regard. The possible factors responsible for the ineffectiveness of synthetic antiandrogens in influencing epididymal metabolism are discussed.