1.
Indian J Exp Biol
;
2005 Jun; 43(6): 531-5
Artigo
em Inglês
| IMSEAR
| ID: sea-60259
RESUMO
The parenteral administration of alpha-lipoic acid (LA) protected against chromate induced oxidative stress in mouse liver. A shift in Cr induced pro-oxidant state to antioxidant-state by LA was noteworthy. The degree of protection was significant and similar in different LA administration regimens (prior-, co- and post- parenteral Cr exposure) explored. An improved status of the tissue antioxidants by LA appeared to be the mechanism of mitigation. The results are of chemopreventive value and suggest a possible alternative to ascorbic acid for abrogation of Cr toxicity.
Assuntos
Animais , Antioxidantes/farmacologia , Carbono/química , Catalase/metabolismo , Cromatos/farmacologia , Cromo/química , Glutationa/metabolismo , Glutationa Redutase/metabolismo , Peroxidação de Lipídeos , Fígado/metabolismo , Masculino , Camundongos , Oxidantes/metabolismo , Estresse Oxidativo , Oxigênio/metabolismo , Dicromato de Potássio/química , Superóxido Dismutase/metabolismo , Ácido Tióctico/química , Fatores de Tempo
2.
Indian J Exp Biol
;
1987 Feb; 25(2): 141-2
Artigo
em Inglês
| IMSEAR
| ID: sea-61189