effect of epstein-barr virus latent membrane protein-1 status on outcome of patients with classic hodgkin's lymphoma

This study determines the expression of latent membrane protein-1 [LMP- 1] in lymph nodes of patients with classic Hodgkin lymphoma [cHL] and its role in patients' survival. Specimen of 98 patients who had cHL was chosen and the samples were immunohistochemically stained with LMP-1 and Overall disease-free survival [DFS] was measured from the date of complete remission until the Relapse was confirmed by another lymph node biopsy. We investigated the expression of LMP-1 in outcome of patients with cHL. LMP-1 was detected in RS cells of cHL in twenty five out of ninety eight [25.5%] patients. LMP-1 expression was significantly more frequent in mixed cellularity, 46.7%, than nodular sclerosis, 15.4% [P= 0.005]. Patients with EBV-positive tumors had fewer DFS [22.6 vs. 25.9 mo], but the difference was not statistically significant [p=0.06]. Although in our study there is no relationship between age and LMP-1 expression. LMP-1 expression is associated with statistically different DFS in treated patients with cHL

É necessária a apendicectomia durante o estadiamento cirúrgico da doença de Hodgkin / Is apendicetomy necessary during surgical staging for Hodgkin's disease

Säo analisados 8 pacientes submetidos a apendicectomia, durante o estadiamento cirúrgico da doença de Hodgkin (DH), dentre um total de 73 casos. Houve predomínio no sexo masculino. A indicaçäo de apendicectomia foi baseada na suspeita do cirurgiäo da presença de DH, palpando nódulo apendicular. O estudo histopatológico dos apêndices vermioformes ressecados apresentou ausência da DH. Quatro pacientes apresentaram estádio patológico III, com 2 complicaçöes pós-operatórias imediatas, ou seja, hemoperitônio e abscesso de parede. É sugerido que a apendicectomia só deva ser realizada quando existe suspeiçäo macroscópica de acometimento apendicular e nos tipos histológicos de pior prognóstico, recomendando-se que näo deva ser procedida rotineiramente no estadiamento cirúrgico da doença de Hodgkin